The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Endonuclease/exonuclease/phosphatase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
460
3D
4jg3A00 - 39.1
2
414
3D
5dv4A00 - 91.9
3
350 - - 73.7
4
323
3D
4cmnA00 - 89.1
5
293
3D
4a9cB00 - 85.3
6
181
3D
1akoA00 - 42.0
7
180 - - 96.3
8
169 - - 75.9
24
154
3D
5j3sA00 - 91.7
9
apurinic or apyrimidinic site
149
3D
2o3cC00 - 81.6
10
139 - - 74.9
11
136 - - 83.9
12
132 - - 87.1
13
131 - - 71.4
26
120
3D
3w2yD00 - 89.6
14
118 - - 80.1
15
109 - - 75.6
16
108 - - 81.2
17
100 - - 76.1
18
98 - - 92.7
19
96 - - 65.7
20
94 - - 55.4
21
91 - - 73.9
22
88 - - 73.2
23
88 - - 79.3
25
Drosophila
88 - - 87.7
27
79 - - 55.8
29
76
3D
1i9zA00 - 85.7
28
74 - - 81.3
35
71
3D
4awnA00 - 71.4
30
apurinic or apyrimidinic site
70 - - 81.2
31
64 - - 73.4
32
64 - - 59.0
33
62 - - 72.0
34
62
3D
5cfeA00 - 71.6
36
56 - - 81.0
37
55 - - 91.9
39
53
3D
2xswB00 - 76.9
38
52 - - 76.2
40
48 - - 93.2
41
apurinic or apyrimidinic site
46 - - 87.5
42
apurinic or apyrimidinic site
44 - - 75.5
43
41 - - 73.2
44
40 - - 77.3
45
40 - - 77.4
46
apurinic or apyrimidinic site
39 - - 66.4
48
36 - - 77.3
63
36
3D
2uyrX00 - 25.0
47
36 - - 72.4
49
35 - - 80.4
50
34 - - 70.4
56
33
3D
1vybB00 - 25.6
51
33 - - 23.6
52
33 - - 33.7
53
32 - - 78.3
54
32
3D
5ewtA00 - 79.8
55
31 - - 61.1
57
30 - - 25.8
58
29 - - 92.2
60
27 - - 91.7
59
27 - - 72.5
61
26 - - 60.3
62
26 - - 82.0
64
23 - - 76.3
65
23 - - 40.0
66
23 - - 77.2
68
22 - - 17.6
67
22 - - 71.3
69
21 - - 80.9
70
21 - - 30.8
71
21 - - 48.0
72
21 - - 88.0
76
20 - - 70.5
74
20 - - 74.5
75
20 - - 5.0
73
20 - - 77.1
77
19 - - 14.3
78
18 - - 6.6
79
apurinic or apyrimidinic site
18 - - 86.8
80
16 - - 83.0
82
16 - - 8.8
81
16 - - 83.0
84
16 - - 0.0
83
Synaptogenin-like
16 - - 52.8
85
16 - - 3.7
86
16 - - 70.7
89
15 - - 5.9
87
15 - - 44.0
88
apurinic or apyrimidinic site
15 - - 6.9
91
14 - - 8.9
92
14 - - 66.5
90
14 - - 15.2
93
14 - - 5.8
99
13 - - 0.0
96
13 - - 65.5
94
13 - - 68.5
95
13 - - 59.3
98
13 - - 17.4
97
13 - - 17.9
102
12 - - 74.4
100
12 - - 35.5
101
12 - - 72.7
105
11 - - 14.9
103
11 - - 51.5
106
11 - - 50.2
121
11
3D
2f2fE00 - 37.4
107
11 - - 47.4
150
11
3D
4gewA02 - 44.6
104
11 - - 82.6
112
10 - - 67.8
111
10 - - 83.3
113
10 - - 55.6
110
10 - - 13.4
108
10 - - 57.4
109
10 - - 83.8
119
9 - - 0.0
118
9 - - 3.9
116
9 - - 74.9
117
9 - - 3.0
120
9 - - 9.9
115
9 - - 33.3
114
9 - - 75.9
142
apurinic or apyrimidinic site
8
3D
2j63B00 - 31.7
128
8 - - 65.0
129
8 - - 83.9
124
8 - - 70.7
131
8 - - 67.8
125
8 - - 73.5
126
8 - - 15.7
127
8 - - 25.9
130
apurinic or apyrimidinic site
8 - - 72.1
122
8 - - 86.7
123
8 - - 91.5
132
AFU_orthologue AFUA_5G07600
7 - - 76.1
139
7 - - 10.1
318
7
3D
2imqX00 - 0.0
133
7 - - 47.4
134
7 - - 4.8
136
7 - - 12.4
137
7 - - 7.9
135
7 - - 0.0
138
7 - - 51.5
140
7 - - 16.7
149
6 - - 18.8
148
Apurinic or apyrimidinic site
6 - - 39.4
141
6 - - 36.0
144
apurinic or apyrimidinic site
6 - - 2.9
143
6 - - 76.2
147
6 - - 9.9
145
6 - - 0.0
146
6 - - 5.1
158
5 - - 75.1
157
5 - - 85.4
156
5 - - 36.7
153
5 - - 11.3
155
apurinic or apyrimidinic site
5 - - 8.9
154
apurinic or apyrimidinic site
5 - - 7.7
152
5 - - 36.5
151
5 - - 38.1
159
5 - - 36.8
170
4 - - 16.7
165
4 - - 2.5
168
4 - - 69.2
178
4 - - 66.9
177
4 - - 39.8
163
4 - - 88.8
171
4 - - 3.3
176
4 - - 78.4
166
4 - - 10.0
175
4 - - 46.0
161
4 - - 14.4
174
4 - - 15.3
164
4 - - 7.9
160
4 - - 56.0
167
4 - - 1.0
173
4 - - 12.3
162
4 - - 69.3
169
4 - - 17.2
172
4 - - 0.0
191
3 - - 7.6
207
3 - - 8.5
184
3 - - 50.6
181
3 - - 12.7
209
3 - - 0.0
192
apurinic or apyrimidinic site
3 - - 9.0
199
3 - - 6.1
183
3 - - 60.9
204
3 - - 78.1
179
3 - - 28.8
193
3 - - 11.3
205
3 - - 0.4
214
3 - - 61.5
186
3 - - 7.9
196
3 - - 8.3
194
3 - - 8.2
185
3 - - 58.8
180
3 - - 37.2
187
3 - - 6.3
212
3 - - 67.3
198
DNase I
3 - - 6.6
202
apurinic or apyrimidinic site
3 - - 8.1
210
apurinic or apyrimidinic site
3 - - 38.6
213
3 - - 49.4
200
3 - - 7.2
195
3 - - 10.8
188
3 - - 0.7
203
3 - - 1.3
211
3 - - 44.8
189
3 - - 0.3
182
Apurinic or apyrimidinic site
3 - - 37.4
206
3 - - 5.0
197
3 - - 0.5
208
3 - - 0.0
201
Apurinic or apyrimidinic site
3 - - 0.0
190
3 - - 7.4
272
2 - - 37.1
262
2 - - 0.0
232
2 - - 35.4
225
2 - - 33.3
278
2 - - 10.1
222
2 - - 35.3
217
2 - - 23.2
281
2 - - 33.9
252
2 - - 0.0
224
IP3
2 - - 31.3
279
2 - - 35.5
263
2 - - 2.7
267
2 - - 0.0
233
2 - - 33.7
280
2 - - 32.6
273
2 - - 31.6
253
2 - - 3.5
258
2 - - 0.0
248
2 - - 6.2
236
2 - - 1.9
234
2 - - 12.4
288
2 - - 35.9
260
2 - - 0.0
227
2 - - 38.2
264
2 - - 13.6
259
2 - - 0.0
249
2 - - 2.4
283
Synaptogenin-like
2 - - 41.1
226
apurinic or apyrimidinic site
2 - - 33.1
244
apurinic or apyrimidinic site
2 - - 3.5
237
2 - - 1.0
235
2 - - 5.5
265
2 - - 0.0
256
2 - - 4.0
215
2 - - 19.1
270
apurinic or apyrimidinic site
2 - - 0.0
261
2 - - 0.0
282
2 - - 9.8
285
2 - - 11.6
246
2 - - 0.0
257
2 - - 8.2
229
2 - - 37.0
284
2 - - 2.2
247
apurinic or apyrimidinic site
2 - - 0.0
289
apurinic or apyrimidinic site
2 - - 38.4
290
2 - - 38.5
271
2 - - 2.0
242
2 - - 7.9
254
2 - - 0.0
243
2 - - 0.0
228
2 - - 32.8
268
apurinic or apyrimidinic site
2 - - 34.9
238
2 - - 3.2
218
2 - - 21.9
221
2 - - 27.0
287
2 - - 36.2
255
2 - - 0.5
274
2 - - 0.3
250
2 - - 8.6
276
2 - - 20.0
240
2 - - 0.0
230
2 - - 39.9
239
apurinic or apyrimidinic site
2 - - 1.1
269
2 - - 39.9
219
2 - - 22.5
220
Synaptogenin-like
2 - - 30.3
286
2 - - 0.0
275
2 - - 0.0
251
2 - - 0.0
245
2 - - 2.5
241
2 - - 0.0
266
2 - - 0.0
231
2 - - 12.0
223
2 - - 25.4
216
2 - - 11.5
277
2 - - 20.1
350
1 - - 0.0
311
1 - - 0.0
294
1 - - 0.0
413
1 - - 0.0
432
1 - - 0.0
359
1 - - 0.0
425
CaLB domain
1 - - 0.0
395
1 - - 0.0
412
1 - - 0.0
326
1 - - 0.0
335
1 - - 0.0
305
1 - - 0.0
319
1 - - 0.0
344
1 - - 0.0
336
1 - - 0.0
383
1 - - 0.0
419
1 - - 0.0
406
1 - - 0.0
365
1 - - 0.0
408
1 - - 0.0
431
1 - - 0.0
382
1 - - 0.0
351
apurinic or apyrimidinic site
1 - - 0.0
405
1 - - 0.0
392
1 - - 0.0
329
1 - - 0.0
346
1 - - 0.0
427
1 - - 0.0
426
1 - - 0.0
414
1 - - 0.0
293
1 - - 0.0
310
Synaptogenin-like
1 - - 0.0
334
1 - - 0.0
362
1 - - 0.0
407
1 - - 0.0
376
1 - - 0.0
371
1 - - 0.0
345
1 - - 0.0
337
1 - - 0.0
430
1 - - 0.0
415
1 - - 0.0
400
1 - - 0.0
320
1 - - 0.0
385
1 - - 0.0
377
1 - - 0.0
338
1 - - 0.0
328
apurinic or apyrimidinic site
1 - - 0.0
397
1 - - 0.0
401
1 - - 0.0
297
1 - - 0.0
364
1 - - 0.0
295
1 - - 0.0
416
1 - - 0.0
300
1 - - 0.0
296
1 - - 0.0
352
1 - - 0.0
428
Synaptogenin-like
1 - - 0.0
394
1 - - 0.0
374
1 - - 0.0
429
1 - - 0.0
409
1 - - 0.0
384
1 - - 0.0
343
1 - - 0.0
321
1 - - 0.0
420
1 - - 0.0
306
1 - - 0.0
340
1 - - 0.0
391
1 - - 0.0
308
apurinic or apyrimidinic site
1 - - 0.0
301
1 - - 0.0
366
1 - - 0.0
349
1 - - 0.0
323
1 - - 0.0
330
1 - - 0.0
360
1 - - 0.0
353
1 - - 0.0
375
1 - - 0.0
387
1 - - 0.0
361
apurinic or apyrimidinic site
1 - - 0.0
307
1 - - 0.0
299
1 - - 0.0
315
1 - - 0.0
317
1 - - 0.0
421
1 - - 0.0
367
1 - - 0.0
342
1 - - 0.0
341
1 - - 0.0
309
1 - - 0.0
399
1 - - 0.0
386
1 - - 0.0
372
1 - - 0.0
322
1 - - 0.0
354
1 - - 0.0
316
1 - - 0.0
314
1 - - 0.0
355
1 - - 0.0
423
1 - - 0.0
422
1 - - 0.0
302
1 - - 0.0
402
1 - - 0.0
298
1 - - 0.0
339
1 - - 0.0
396
1 - - 0.0
356
apurinic or apyrimidinic site
1 - - 0.0
325
1 - - 0.0
378
1 - - 0.0
389
1 - - 0.0
410
1 - - 0.0
417
1 - - 0.0
381
1 - - 0.0
373
1 - - 0.0
333
1 - - 0.0
393
1 - - 0.0
303
1 - - 0.0
424
1 - - 0.0
347
1 - - 0.0
363
1 - - 0.0
313
1 - - 0.0
404
1 - - 0.0
357
1 - - 0.0
390
1 - - 0.0
331
1 - - 0.0
358
1 - - 0.0
418
1 - - 0.0
348
1 - - 0.0
388
1 - - 0.0
324
1 - - 0.0
379
Drosophila
1 - - 0.0
312
1 - - 0.0
370
1 - - 0.0
380
Apurinic or apyrimidinic site
1 - - 0.0
369
1 - - 0.0
332
1 - - 0.0
368
1 - - 0.0
292
1 - - 0.0
291
1 - - 0.0
327
1 - - 0.0
433
1 - - 0.0
411
1 - - 0.0
398
1 - - 0.0
304
1 - - 0.0
403
1 - - 0.0