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CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Thioredoxin reductase 1, cytoplasmic

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Thioredoxin-disulfide reductase. [EC: 1.8.1.9]
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
  • May be identical to EC 1.8.1.10.
  • Formerly EC 1.6.4.5.
 15 O62768 O89049 P91938 Q16881 Q17745 Q5NVA2 Q86VQ6 Q99MD6 Q9JLT4 Q9JMH6
(5 more...)
Glutathione-disulfide reductase. [EC: 1.8.1.7]
2 glutathione + NADP(+) = glutathione disulfide + NADPH.
  • Activity is dependent on a redox-active disulfide in each of the active centers.
  • Formerly EC 1.6.4.2.
 1 P30635