The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ureohydrolase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Arginase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Arginase activity GO:0004053
Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
5 P78540 (/IMP) P78540 (/IMP) P78540 (/IMP) P78540 (/IMP) P78540 (/IMP)
Arginase activity GO:0004053
Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
5 P78540 (/TAS) P78540 (/TAS) P78540 (/TAS) P78540 (/TAS) P78540 (/TAS)
Arginase activity GO:0004053
Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
2 F1P5B4 (/IDA) O08701 (/IDA)
Arginase activity GO:0004053
Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
1 O08691 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O08701 (/IPI)
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
1 O08701 (/IPI)
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
1 O08691 (/ISO)

There are 53 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Urea cycle GO:0000050
The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
5 P78540 (/TAS) P78540 (/TAS) P78540 (/TAS) P78540 (/TAS) P78540 (/TAS)
Nitric oxide biosynthetic process GO:0006809
The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
5 P78540 (/TAS) P78540 (/TAS) P78540 (/TAS) P78540 (/TAS) P78540 (/TAS)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
5 P78540 (/IMP) P78540 (/IMP) P78540 (/IMP) P78540 (/IMP) P78540 (/IMP)
Positive regulation of cellular senescence GO:2000774
Any process that activates or increases the frequency, rate or extent of cellular senescence.
5 P78540 (/IDA) P78540 (/IDA) P78540 (/IDA) P78540 (/IDA) P78540 (/IDA)
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
1 O08691 (/IEP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 O08701 (/IEP)
Negative regulation of type 2 immune response GO:0002829
Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
1 O08691 (/IMP)
Arginine metabolic process GO:0006525
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 O08701 (/IMP)
Arginine metabolic process GO:0006525
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 O08691 (/ISO)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 O08701 (/IEP)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
1 O08691 (/IMP)
Midgut development GO:0007494
The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
1 O08701 (/IEP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 O08701 (/IEP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
1 O08701 (/IEP)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 O08701 (/IEP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 O08701 (/IEP)
Response to selenium ion GO:0010269
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion.
1 O08701 (/IEP)
Regulation of L-arginine import GO:0010963
Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle.
1 O08701 (/IDA)
Regulation of L-arginine import GO:0010963
Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle.
1 O08691 (/ISO)
Response to amine GO:0014075
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
1 O08701 (/IEP)
Arginine catabolic process to ornithine GO:0019547
The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.
1 O08701 (/IDA)
Arginine catabolic process to ornithine GO:0019547
The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.
1 O08691 (/ISO)
Arginine catabolic process to ornithine GO:0019547
The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.
1 O08701 (/TAS)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
1 O08701 (/IEP)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 O08691 (/ISO)
Response to vitamin E GO:0033197
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus.
1 O08701 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 O08701 (/IEP)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
1 O08701 (/IEP)
Regulation of nitric oxide biosynthetic process GO:0045428
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 O08701 (/IEP)
Negative regulation of striated muscle contraction GO:0045988
Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.
1 O08701 (/IMP)
Negative regulation of striated muscle contraction GO:0045988
Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.
1 O08691 (/ISO)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 O08701 (/IEP)
Response to mercury ion GO:0046689
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.
1 O08701 (/IEP)
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
1 O08701 (/IEP)
Regulation of interleukin-1 beta secretion GO:0050706
Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
1 O08691 (/IMP)
Negative regulation of nitric-oxide synthase activity GO:0051001
Any process that stops or reduces the activity of the enzyme nitric-oxide synthase.
1 O08701 (/IMP)
Negative regulation of nitric-oxide synthase activity GO:0051001
Any process that stops or reduces the activity of the enzyme nitric-oxide synthase.
1 O08691 (/ISO)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
1 O08701 (/IEP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 O08701 (/IEP)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
1 O08701 (/IEP)
Cellular response to interleukin-4 GO:0071353
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.
1 O08701 (/IEP)
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
1 O08701 (/IEP)
Negative regulation of macrophage inflammatory protein 1 alpha production GO:0071641
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha.
1 O08691 (/IMP)
Negative regulation of chemokine (C-C motif) ligand 4 production GO:0071644
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4.
1 O08691 (/IMP)
Negative regulation of chemokine (C-C motif) ligand 5 production GO:0071650
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5.
1 O08691 (/IMP)
Negative regulation of defense response to bacterium GO:1900425
Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.
1 O08691 (/IMP)
Regulation of reactive oxygen species biosynthetic process GO:1903426
Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.
1 O08691 (/IMP)
Negative regulation of tumor necrosis factor secretion GO:1904468
Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor secretion.
1 O08691 (/IMP)
Negative regulation of interleukin-17 secretion GO:1905077
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17 secretion.
1 O08691 (/IMP)
Negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process GO:1905403
Any process that stops, prevents or reduces the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process.
1 O08691 (/IMP)
Negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562
Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation.
1 O08691 (/IMP)
Negative regulation of interleukin-13 secretion GO:2000666
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-13 secretion.
1 O08691 (/IMP)
Positive regulation of cellular senescence GO:2000774
Any process that activates or increases the frequency, rate or extent of cellular senescence.
1 O08691 (/ISO)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 P78540 (/TAS) P78540 (/TAS) P78540 (/TAS) P78540 (/TAS) P78540 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
5 P78540 (/TAS) P78540 (/TAS) P78540 (/TAS) P78540 (/TAS) P78540 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O08691 (/IDA) O08701 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O08691 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O08691 (/ISO)