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Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1134
3D
2rc4A02 - 88.4
2
1043
3D
2ou2A02 - 87.9
3
800 - - 83.2
4
604
3D
4nsqD00 - 80.7
7
1
438
3D
4r9mC00 - 69.3
5
376 - - 95.4
6
348 - - 95.5
8
291 - - 39.0
9
256 - - 63.4
11
253
3D
3bj8D00 - 94.7
10
253 - - 80.2
12
210 - - 38.0
13
208 - - 86.6
14
205
3D
6c9mD00 - 65.9
15
201 - - 76.5
18
195
3D
2cntD00 - 78.9
16
192 - - 95.0
17
191 - - 77.8
19
181 - - 65.7
26
179
3D
3dr8B00 - 93.8
20
178
3D
4h6zB02 - 78.7
21
175
3D
1l0cA00 - 79.9
22
165
3D
2p0wB02 - 77.3
25
156
3D
2vqyA00 - 43.7
23
153 - - 78.4
24
149 - - 52.5
29
147
3D
4ab7H02 - 98.0
28
141
3D
5icwB00 - 68.5
27
140 - - 8.4
31
129
3D
3cxsA01 - 74.7
30
123 - - 80.7
42
116
3D
2p6gF01 - 78.7
32
115 - - 26.7
33
113 - - 86.4
34
112 - - 77.3
35
110
3D
1xebH00 - 85.8
56
100
3D
2p6gF02 - 89.3
36
96 - - 11.1
46
89
3D
3v8iB00 - 97.1
38
87
3D
5ls7B00 - 10.1
37
85 - - 76.8
43
78
3D
4ag9B01 - 92.9
39
78 - - 80.3
40
putative
77 - - 78.9
41
76 - - 84.1
44
76
3D
2ft0B00 - 53.0
45
74
3D
4k30Y00 - 78.4
47
69
3D
3tcvB00 - 94.0
52
69
3D
1z9uB00 - 33.9
48
68
3D
3t90A00 - 93.3
49
65 - - 85.3
50
64 - - 8.9
60
64
3D
4u9zA00 - 86.4
51
63 - - 75.7
54
Met
61
3D
2zpaB03 - 69.3
55
61
3D
1y9wB01 - 77.1
62
60
3D
3fxtH00 - 92.3
53
60 - - 73.4
57
57 - - 42.5
58
Nat5
55 - - 74.4
59
54 - - 78.0
66
53
3D
1qsoD00 - 89.8
61
N
alpha
53 - - 70.2
64
51
3D
2fe7B00 - 93.7
63
50 - - 57.6
112
49
3D
6b3tA01 - 94.7
65
48 - - 89.0
67
43 - - 81.6
71
43
3D
4f0yB00 - 80.6
68
43 - - 23.4
70
42
3D
3s6kA02 - 80.5
69
41 - - 13.9
78
38
3D
2pswC00 - 16.9
72
35 - - 92.7
74
N
alpha
34 - - 24.0
73
34 - - 74.4
76
33 - - 89.9
75
33 - - 73.4
77
32 - - 89.0
80
31 - - 70.7
81
31 - - 36.2
82
31 - - 67.5
79
31 - - 38.4
98
30
3D
4kvoH00 - 53.0
136
29
3D
1i21Y00 - 82.8
89
29
3D
2c27A00 - 45.8
83
NAT
29 - - 68.0
84
28 - - 65.9
86
27 - - 84.0
87
27 - - 5.2
85
27 - - 62.4
90
26 - - 24.6
88
26 - - 71.7
106
26
3D
2q4yA00 - 97.1
107
25
3D
4xpdB00 - 52.1
91
25 - - 86.3
94
24 - - 74.0
93
24 - - 29.4
92
24 - - 59.4
105
24
3D
3i3gB00 - 93.8
96
23 - - 18.4
95
23 - - 79.8
97
22 - - 75.1
114
22
3D
4psxD02 - 86.4
99
21 - - 73.7
100
21 - - 95.0
101
20 - - 57.3
111
6'
20
3D
1s3zB00 - 1.5
103
20 - - 38.7
149
AAC(2'
20
3D
1m4iB00 - 9.1
148
20
3D
1yk3H00 - 0.0
104
20 - - 80.2
102
20 - - 6.3
109
19 - - 10.8
108
19 - - 76.7
110
19 - - 17.4
176
19
3D
2vzzD00 - 0.0
113
18 - - 65.9
115
18 - - 10.7
116
18 - - 75.8
133
18
3D
1mk4B00 - 93.6
117
17 - - 71.0
119
17 - - 17.2
122
GNAT
17 - - 1.4
120
N
alpha
17 - - 0.0
118
17 - - 72.7
124
17 - - 72.0
121
17 - - 9.2
183
17
3D
5ib0G00 - 0.0
123
17 - - 2.4
125
16 - - 71.6
132
16 - - 78.7
126
16 - - 8.2
130
16 - - 14.2
128
16 - - 88.8
129
16 - - 2.6
127
16 - - 12.0
131
16 - - 5.0
200
15
3D
5c88B00 - 83.5
135
15 - - 37.3
134
15 - - 2.4
194
15
3D
4avcB02 - 31.2
140
Met
14 - - 83.1
138
14 - - 54.2
203
14
3D
4y49O00 - 0.7
137
14 - - 0.0
139
14 - - 54.6
171
13
3D
2h5mA00 - 10.0
143
13 - - 12.7
141
13 - - 56.1
144
13 - - 5.7
142
13 - - 79.4
150
12 - - 25.5
147
12 - - 2.4
156
12 - - 68.7
215
12
3D
4x5kA00 - 26.6
152
12 - - 4.6
155
12 - - 0.8
153
12 - - 0.0
151
12 - - 0.7
157
12 - - 11.7
146
12 - - 42.7
154
12 - - 0.0
145
12 - - 16.7
158
12 - - 98.1
177
11 - - 6.9
179
11 - - 36.9
164
11 - - 39.3
168
11 - - 84.7
173
11 - - 0.0
178
11 - - 0.0
163
11 - - 45.6
161
11 - - 33.1
180
11 - - 78.8
167
11 - - 80.1
169
11 - - 9.7
174
11 - - 10.2
165
11 - - 53.4
162
11 - - 45.9
166
11 - - 77.3
170
11 - - 8.1
159
11 - - 74.1
181
11 - - 92.3
160
11 - - 0.0
172
11 - - 8.3
175
11 - - 6.8
186
10 - - 14.2
192
10 - - 93.5
185
10 - - 3.3
182
10 - - 82.6
190
10 - - 0.0
188
10 - - 0.0
184
10 - - 11.0
191
10 - - 98.7
187
10 - - 0.7
189
10 - - 0.0
210
9 - - 41.5
195
9 - - 33.8
196
9 - - 19.9
206
9 - - 4.3
202
9 - - 14.0
205
9 - - 0.7
209
9 - - 77.4
198
NAT
9 - - 41.3
207
9 - - 0.8
201
9 - - 7.5
199
9 - - 82.9
197
9 - - 1.9
208
9 - - 27.2
204
9 - - 7.5
193
9 - - 42.3
224
8 - - 0.0
216
8 - - 73.1
221
8 - - 0.0
212
8 - - 13.3
223
8 - - 16.7
213
8 - - 0.0
217
8 - - 13.2
219
8 - - 7.4
225
8 - - 45.2
222
8 - - 5.0
211
8 - - 74.9
214
8 - - 67.9
220
8 - - 0.0
218
8 - - 0.0
228
7 - - 5.6
240
7 - - 0.0
238
7 - - 10.0
234
7 - - 84.5
237
7 - - 18.2
239
7 - - 11.2
242
7 - - 1.5
231
7 - - 48.6
245
7 - - 6.5
246
7 - - 18.9
229
7 - - 2.2
227
7 - - 4.1
233
7 - - 34.1
243
7 - - 3.9
235
7 - - 0.0
226
7 - - 43.4
241
7 - - 3.1
232
7 - - 44.6
247
7 - - 2.6
236
7 - - 13.0
244
7 - - 12.4
248
7 - - 82.5
230
Met
7 - - 0.0
266
6 - - 0.7
253
6 - - 16.5
262
6 - - 0.0
265
6 - - 0.0
251
6 - - 6.8
270
6 - - 8.3
257
6 - - 61.7
259
6 - - 14.1
260
6 - - 0.0
281
NAT
6 - - 78.2
254
6 - - 0.0
276
6 - - 0.0
621
6
3D
2g0bH01 - 0.0
258
6 - - 3.9
275
6 - - 9.3
272
6 - - 3.2
264
6 - - 14.4
271
6 - - 0.0
250
6 - - 7.4
277
6 - - 0.0
279
6 - - 30.5
268
6 - - 0.0
273
6 - - 2.9
282
6 - - 94.3
249
6 - - 20.6
278
6 - - 83.7
255
6 - - 24.4
263
6 - - 0.0
252
6 - - 23.5
256
6 - - 87.4
274
6 - - 1.6
280
6 - - 85.8
261
6 - - 14.9
267
6 - - 0.0
269
6 - - 8.0
298
5 - - 5.1
288
5 - - 74.0
302
5 - - 36.1
305
N
alpha
5 - - 77.8
294
5 - - 7.6
284
5 - - 23.2
306
5 - - 84.2
287
N
alpha
5 - - 42.6
289
5 - - 83.1
291
5 - - 16.5
299
5 - - 7.8
297
5 - - 4.0
293
5 - - 1.2
300
5 - - 0.0
283
5 - - 78.4
296
5 - - 0.0
285
5 - - 33.2
304
5 - - 63.9
286
5 - - 42.4
295
5 - - 8.9
292
5 - - 10.4
379
1
5
3D
3k9uB00 - 0.0
301
5 - - 0.0
290
5 - - 52.4
303
5 - - 36.4
312
Arylalkylamine N-AcetylTransferase
4 - - 18.0
321
4 - - 0.0
346
N
alpha
4 - - 45.0
315
4 - - 69.6
327
4 - - 0.0
329
4 - - 4.4
339
4 - - 0.0
337
4 - - 0.0
342
4 - - 0.0
331
4 - - 8.2
316
4 - - 16.3
345
4 - - 11.0
333
4 - - 18.5
323
4 - - 14.6
340
NAT
4 - - 7.9
338
4 - - 9.6
328
4 - - 12.7
310
4 - - 77.7
334
4 - - 3.3
324
4 - - 10.4
344
4 - - 78.1
314
4 - - 17.1
308
4 - - 16.6
348
4 - - 84.4
330
4 - - 0.0
320
4 - - 5.5
318
4 - - 0.0
307
4 - - 74.8
309
4 - - 0.0
343
4 - - 69.0
313
4 - - 24.1
447
4
3D
2wpxB00 - 0.0
319
4 - - 9.8
317
4 - - 0.0
325
4 - - 15.1
336
4 - - 0.0
311
4 - - 18.5
322
4 - - 0.0
326
4 - - 12.6
335
4 - - 6.0
341
4 - - 9.0
332
4 - - 1.8
349
4 - - 18.7
347
4 - - 57.4
445
3
3D
2z0zA00 - 0.0
354
3 - - 0.0
360
3 - - 69.2
381
3 - - 0.0
387
3 - - 35.1
358
3 - - 41.7
375
3 - - 9.0
372
3 - - 0.0
383
3 - - 5.8
376
3 - - 9.2
388
3 - - 57.3
362
3 - - 4.4
353
3 - - 0.0
365
3 - - 14.1
366
3 - - 0.0
384
3 - - 0.0
351
3 - - 13.3
370
3 - - 0.6
359
3 - - 16.1
357
3 - - 1.6
356
3 - - 16.8
378
3 - - 0.0
355
3 - - 0.0
352
3 - - 59.9
363
3 - - 0.0
380
3 - - 9.1
361
3 - - 6.7
369
3 - - 6.9
367
3 - - 5.3
374
3 - - 7.2
371
NAT
3 - - 7.8
350
3 - - 71.2
377
3 - - 1.5
364
3 - - 5.9
386
3 - - 12.2
368
3 - - 5.7
382
3 - - 15.9
373
3 - - 9.3
385
3 - - 0.0
416
2 - - 19.8
487
2 - - 0.0
506
Met
2 - - 0.0
489
2 - - 0.0
391
2 - - 65.7
431
2 - - 0.0
442
2 - - 0.0
397
2 - - 0.0
399
2 - - 7.5
481
2 - - 9.3
437
2 - - 0.0
439
2 - - 13.3
460
2 - - 0.0
454
2 - - 0.0
499
AFU_orthologue AFUA_3G11780
2 - - 0.0
429
2 - - 8.9
497
2 - - 11.0
427
2 - - 0.0
446
2 - - 5.6
505
2 - - 0.0
415
2 - - 38.2
491
6'
2 - - 0.0
421
2 - - 31.7
389
2 - - 33.9
412
2 - - 2.8
502
2 - - 0.0
406
2 - - 11.8
516
2 - - 41.2
423
2 - - 37.8
493
2 - - 0.0
476
2 - - 8.2
483
2 - - 1.9
472
2 - - 0.0
475
2 - - 5.5
393
2 - - 24.7
515
2 - - 43.9
405
2 - - 0.0
402
2 - - 2.5
458
2 - - 10.3
433
2 - - 0.0
512
2 - - 36.1
410
2 - - 8.7
500
2 - - 0.0
466
2 - - 8.8
498
2 - - 4.8
428
2 - - 0.0
398
2 - - 3.0
465
2 - - 0.0
453
2 - - 0.0
438
2 - - 11.7
462
2 - - 0.0
488
2 - - 0.0
440
2 - - 0.0
494
2 - - 9.9
424
2 - - 40.7
400
2 - - 4.4
457
2 - - 0.0
510
2 - - 36.2
459
2 - - 0.0
470
2 - - 9.7
451
2 - - 0.0
484
2 - - 0.0
434
2 - - 5.2
394
2 - - 2.5
463
2 - - 0.0
452
2 - - 0.0
408
O-GlcNAcase
2 - - 1.0
455
2 - - 0.0
478
2 - - 0.0
414
2 - - 0.0
504
2 - - 0.0
444
2 - - 0.0
456
2 - - 8.8
508
2 - - 26.9
418
2 - - 21.3
474
2 - - 0.0
490
2 - - 0.0
420
2 - - 31.6
404
2 - - 4.6
514
2 - - 42.0
467
2 - - 4.2
469
2 - - 0.0
430
2 - - 3.4
390
2 - - 0.0
448
2 - - 0.0
461
2 - - 0.0
480
2 - - 1.4
464
2 - - 0.0
503
2 - - 0.0
413
2 - - 0.0
401
2 - - 9.9
443
2 - - 0.0
511
2 - - 44.2
477
2 - - 0.0
479
2 - - 11.7
409
2 - - 0.0
450
2 - - 0.9
407
2 - - 0.0
471
2 - - 0.0
485
2 - - 11.4
449
2 - - 0.0
473
2 - - 7.0
482
2 - - 0.0
395
2 - - 9.4
468
NAT
2 - - 7.6
432
2 - - 0.0
513
2 - - 41.4
441
2 - - 0.0
403
2 - - 0.0
435
2 - - 0.0
392
2 - - 13.8
426
2 - - 0.0
496
6
2 - - 0.0
396
2 - - 11.7
422
2 - - 39.1
492
2 - - 0.0
411
2 - - 0.0
501
2 - - 8.2
436
NAT
2 - - 0.0
425
2 - - 6.7
495
6
2 - - 0.0
507
2 - - 0.0
486
2 - - 0.0
417
2 - - 24.1
419
2 - - 31.0
509
2 - - 35.7
634
1 - - 0.0
523
1 - - 0.0
593
1 - - 0.0
684
1 - - 0.0
576
1 - - 0.0
572
1 - - 0.0
651
1 - - 0.0
583
1 - - 0.0
670
1 - - 0.0
575
1 - - 0.0
659
1 - - 0.0
657
1 - - 0.0
600
1 - - 0.0
558
1 - - 0.0
533
1 - - 0.0
624
1 - - 0.0
694
1 - - 0.0
589
1 - - 0.0
640
1 - - 0.0
545
1 - - 0.0
587
1 - - 0.0
542
1 - - 0.0
531
1 - - 0.0
688
1 - - 0.0
581
NAT
1 - - 0.0
662
1 - - 0.0
638
1 - - 0.0
653
1 - - 0.0
539
1 - - 0.0
560
1 - - 0.0
537
1 - - 0.0
665
1 - - 0.0
554
1 - - 0.0
628
1 - - 0.0
698
1 - - 0.0
597
1 - - 0.0
527
1 - - 0.0
599
1 - - 0.0
529
1 - - 0.0
666
1 - - 0.0
610
1 - - 0.0
546
1 - - 0.0
591
1 - - 0.0
521
1 - - 0.0
594
1 - - 0.0
524
1 - - 0.0
633
1 - - 0.0
658
1 - - 0.0
602
1 - - 0.0
605
1 - - 0.0
559
1 - - 0.0
557
1 - - 0.0
570
1 - - 0.0
675
1 - - 0.0
672
1 - - 0.0
551
1 - - 0.0
683
NAT
1 - - 0.0
676
1 - - 0.0
584
1 - - 0.0
693
1 - - 0.0
623
1 - - 0.0
534
1 - - 0.0
606
1 - - 0.0
612
1 - - 0.0
691
1 - - 0.0
615
1 - - 0.0
646
1 - - 0.0
627
1 - - 0.0
697
1 - - 0.0
629
1 - - 0.0
699
1 - - 0.0
566
1 - - 0.0
598
1 - - 0.0
528
1 - - 0.0
654
1 - - 0.0
660
1 - - 0.0
639
1 - - 0.0
565
1 - - 0.0
637
1 - - 0.0
681
1 - - 0.0
562
1 - - 0.0
553
1 - - 0.0
538
1 - - 0.0
631
1 - - 0.0
642
1 - - 0.0
588
1 - - 0.0
689
1 - - 0.0
540
1 - - 0.0
645
1 - - 0.0
687
1 - - 0.0
616
1 - - 0.0
574
1 - - 0.0
518
1 - - 0.0
619
1 - - 0.0
617
1 - - 0.0
686
NAT
1 - - 0.0
695
1 - - 0.0
625
1 - - 0.0
590
1 - - 0.0
520
1 - - 0.0
636
1 - - 0.0
611
1 - - 0.0
692
1 - - 0.0
622
1 - - 0.0
696
1 - - 0.0
626
1 - - 0.0
569
1 - - 0.0
530
1 - - 0.0
635
1 - - 0.0
567
GNAT
1 - - 0.0
603
1 - - 0.0
632
1 - - 0.0
641
1 - - 0.0
668
1 - - 0.0
682
1 - - 0.0
561
1 - - 0.0
548
1 - - 0.0
673
1 - - 0.0
580
1 - - 0.0
649
1 - - 0.0
647
1 - - 0.0
685
1 - - 0.0
671
1 - - 0.0
552
1 - - 0.0
563
1 - - 0.0
607
1 - - 0.0
650
1 - - 0.0
555
GNAT
1 - - 0.0
609
1 - - 0.0
679
1 - - 0.0
677
1 - - 0.0
643
1 - - 0.0
601
1 - - 0.0
578
1 - - 0.0
544
1 - - 0.0
613
1 - - 0.0
664
1 - - 0.0
556
1 - - 0.0
680
1 - - 0.0
549
1 - - 0.0
547
1 - - 0.0
585
1 - - 0.0
582
1 - - 0.0
661
1 - - 0.0
648
1 - - 0.0
573
1 - - 0.0
541
1 - - 0.0
532
1 - - 0.0
568
1 - - 0.0
526
1 - - 0.0
596
1 - - 0.0
630
1 - - 0.0
669
1 - - 0.0
667
1 - - 0.0
535
1 - - 0.0
522
1 - - 0.0
592
1 - - 0.0
604
1 - - 0.0
525
1 - - 0.0
595
1 - - 0.0
620
1 - - 0.0
690
1 - - 0.0
536
1 - - 0.0
519
1 - - 0.0
586
1 - - 0.0
517
1 - - 0.0
674
1 - - 0.0
618
1 - - 0.0
656
1 - - 0.0
564
1 - - 0.0
644
1 - - 0.0
614
1 - - 0.0
543
1 - - 0.0
678
1 - - 0.0
579
1 - - 0.0
577
1 - - 0.0
550
1 - - 0.0
655
1 - - 0.0
571
1 - - 0.0
608
1 - - 0.0
652
1 - - 0.0
663
1 - - 0.0
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