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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Acetolactate synthase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Tartronate-semialdehyde synthase. [EC: 4.1.1.47]
2 glyoxylate = tartronate semialdehyde + CO(2).
    		 1122 A0A070SKL6 A0A070SKL6 A0A070SKL6 A0A070SKL6 A0A070SKL6 A0A070SKL6 A0A070SKL6 A0A070SKL6 A0A070SKL6 A0A070SKL6
    (1112 more...)
    Acetolactate synthase. [EC: 2.2.1.6]
    2 pyruvate = 2-acetolactate + CO(2).
    • The reaction shown is in the pathway of biosynthesis of valine.
    • The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
    • Formerly EC 4.1.3.18.
    		 897 A0A037YIK2 A0A037YIK2 A0A037YIK2 A0A037YIK2 A0A037YIK2 A0A037YIK2 A0A037YIK2 A0A037YIK2 A0A037YIK2 A0A037YIK2
    (887 more...)
    N(2)-(2-carboxyethyl)arginine synthase. [EC: 2.5.1.66]
    D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L- arginine + phosphate.
    • Requires thiamine diphosphate and catalyzes the first step in the clavulanic-acid biosynthesis pathway.
    • The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.
    		 4 B5GLC6 B5GLC6 Q9LCV9 Q9LCV9