The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Malate dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
95 P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA)
(85 more)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
95 P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA)
(85 more)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
95 P61889 (/IMP) P61889 (/IMP) P61889 (/IMP) P61889 (/IMP) P61889 (/IMP) P61889 (/IMP) P61889 (/IMP) P61889 (/IMP) P61889 (/IMP) P61889 (/IMP)
(85 more)
Malic enzyme activity GO:0004470
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
7 P82177 (/ISS) Q9KUT3 (/ISS) Q9KUT3 (/ISS) Q9KUT3 (/ISS) Q9KUT3 (/ISS) Q9KUT3 (/ISS) Q9KUT3 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P17505 (/IPI) P17505 (/IPI) P17505 (/IPI) P17505 (/IPI) P17505 (/IPI) P17505 (/IPI) Q9SN86 (/IPI)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
7 P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) Q9SN86 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
6 P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
6 P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
3 O15769 (/EXP) O15769 (/EXP) Q38BY9 (/EXP)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
3 O15769 (/EXP) O15769 (/EXP) Q38BY9 (/EXP)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
2 O02640 (/ISS) Q9Y7R8 (/ISS)
NAD(P)+ transhydrogenase activity GO:0008746
Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.
1 Q9SN86 (/IMP)
Chloroplast protein-transporting ATPase activity GO:0016464
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma.
1 Q9SN86 (/IDA)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
1 P82177 (/ISS)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
1 P83778 (/NAS)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
95 P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA)
(85 more)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
95 P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA)
(85 more)
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
95 P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA)
(85 more)
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
95 P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA)
(85 more)
Anaerobic respiration GO:0009061
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.
95 P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA)
(85 more)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
8 P82177 (/ISS) Q9KUT3 (/ISS) Q9KUT3 (/ISS) Q9KUT3 (/ISS) Q9KUT3 (/ISS) Q9KUT3 (/ISS) Q9KUT3 (/ISS) Q9Y7R8 (/ISS)
Chronological cell aging GO:0001300
The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
6 P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP)
Replicative cell aging GO:0001302
The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.
6 P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
6 P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
6 P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
3 O15769 (/ISM) O15769 (/ISM) Q38BY9 (/ISM)
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
2 O02640 (/ISS) Q9Y7R8 (/ISS)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
1 Q4Q3J2 (/EXP)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
1 P83778 (/NAS)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 Q9SN86 (/IEP)
Chloroplast organization GO:0009658
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast.
1 Q9SN86 (/IMP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
1 Q9SN86 (/IDA)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
1 Q9SN86 (/IMP)
Protein import into chloroplast stroma GO:0045037
The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import.
1 Q9SN86 (/IMP)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
95 P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA)
(85 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
95 P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA)
(85 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
95 P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA)
(85 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
95 P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA) P61889 (/HDA)
(85 more)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
95 P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA) P61889 (/IDA)
(85 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 O15769 (/IDA) O15769 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) Q38BY9 (/IDA) Q9SN86 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
8 O02640 (/HDA) P17505 (/HDA) P17505 (/HDA) P17505 (/HDA) P17505 (/HDA) P17505 (/HDA) P17505 (/HDA) Q9Y7R8 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP) P17505 (/IMP)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 P17505 (/IPI) P17505 (/IPI) P17505 (/IPI) P17505 (/IPI) P17505 (/IPI) P17505 (/IPI)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
6 P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA) P17505 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 O15769 (/RCA) O15769 (/RCA) Q38BY9 (/RCA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
3 O15769 (/RCA) O15769 (/RCA) Q38BY9 (/RCA)
Kinetoplast GO:0020023
A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum.
3 O15769 (/IDA) O15769 (/IDA) Q38BY9 (/IDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
2 Q5AMP4 (/IDA) Q5AMP4 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q4Q3J2 (/EXP)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O02640 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P83778 (/NAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q9Y7R8 (/ISS)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
1 Q9SN86 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q9SN86 (/IDA)
Plastid stroma GO:0009532
The proteinaceous ground substance of plastids.
1 Q9SN86 (/IDA)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
1 Q9SN86 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 Q9SN86 (/IDA)
Chloroplast inner membrane GO:0009706
The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma.
1 Q9SN86 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 Q9SN86 (/IDA)
Stromule GO:0010319
Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types.
1 Q9SN86 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9SN86 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
1 Q9SN86 (/IDA)
Ycf2/FtsHi complex GO:0062091
A protein complex located in the chloroplast inner membrane and facing the stroma that is associated with the chloroplast inner membrane translocase complex and provides the ATPase motor activity to drive import of proteins into the chloroplast stroma.
1 Q9SN86 (/IDA)