The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 998: Thymidine kinase 2, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Deoxycytidine kinase activity GO:0004137
Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
1 D3ZGQ2 (/IDA)
Deoxycytidine kinase activity GO:0004137
Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
1 Q9R088 (/ISO)
Thymidine kinase activity GO:0004797
Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.
1 D3ZGQ2 (/IDA)
Thymidine kinase activity GO:0004797
Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.
1 Q9R088 (/ISO)
Thymidine kinase activity GO:0004797
Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.
1 Q9R088 (/ISS)
Thymidine kinase activity GO:0004797
Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.
1 O00142 (/TAS)
Nucleoside kinase activity GO:0019206
Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.
1 O00142 (/TAS)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
1 O00142 (/TAS)
Mitochondrial DNA replication GO:0006264
The process in which new strands of DNA are synthesized in the mitochondrion.
1 Q9R088 (/IMP)
Deoxyribonucleotide metabolic process GO:0009262
The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 Q9R088 (/IMP)
Mitochondrial DNA metabolic process GO:0032042
The chemical reactions and pathways involving mitochondrial DNA.
1 Q9R088 (/IMP)
Pyrimidine nucleoside salvage GO:0043097
Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis.
1 O00142 (/TAS)
Deoxycytidine metabolic process GO:0046092
The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.
1 D3ZGQ2 (/IDA)
Deoxycytidine metabolic process GO:0046092
The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.
1 Q9R088 (/ISO)
Thymidine metabolic process GO:0046104
The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.
1 D3ZGQ2 (/IDA)
Thymidine metabolic process GO:0046104
The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.
1 Q9R088 (/ISO)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 D3ZGQ2 (/IDA) Q9R088 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9R088 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9R088 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q9R088 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 O00142 (/TAS)
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