The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 780: Rho GTPase Rho3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
14 A0A1D8PH96 (/IDA) A0A1D8PH96 (/IDA) A0A1D8PH96 (/IDA) A0A1D8PH96 (/IDA) O13928 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA)
(4 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 O13928 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
9 Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 O13928 (/ISM)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Establishment or maintenance of actin cytoskeleton polarity GO:0030950
Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.
9 Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
9 Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
9 Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
9 Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI) Q00245 (/IPI)
Positive regulation of formin-nucleated actin cable assembly GO:0090338
Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
9 Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI) Q00245 (/IGI)
Positive regulation of formin-nucleated actin cable assembly GO:0090338
Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
9 Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP) Q00245 (/IMP)
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
4 A0A1D8PH96 (/IMP) A0A1D8PH96 (/IMP) A0A1D8PH96 (/IMP) A0A1D8PH96 (/IMP)
Hyphal growth GO:0030448
Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
4 A0A1D8PH96 (/IMP) A0A1D8PH96 (/IMP) A0A1D8PH96 (/IMP) A0A1D8PH96 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 O13928 (/IMP)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
1 O13928 (/IC)
Regulation of septum digestion after cytokinesis GO:0010590
Any process that modulates the rate, frequency or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis.
1 O13928 (/IMP)
Regulation of exocytosis GO:0017157
Any process that modulates the frequency, rate or extent of exocytosis.
1 O13928 (/TAS)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 O13928 (/IMP)
Establishment or maintenance of cell polarity regulating cell shape GO:0071963
Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell.
1 O13928 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 Q00245 (/HDA) Q00245 (/HDA) Q00245 (/HDA) Q00245 (/HDA) Q00245 (/HDA) Q00245 (/HDA) Q00245 (/HDA) Q00245 (/HDA) Q00245 (/HDA)
Cellular bud GO:0005933
A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated.
9 Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA) Q00245 (/IDA)
Hyphal tip GO:0001411
The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.
5 E9RB80 (/IDA) E9RB80 (/IDA) E9RB80 (/IDA) E9RB80 (/IDA) E9RB80 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 A0A1D8PH96 (/IDA) A0A1D8PH96 (/IDA) A0A1D8PH96 (/IDA) A0A1D8PH96 (/IDA) O13928 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O13928 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O13928 (/HDA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 O13928 (/EXP)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 O13928 (/IDA)
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