The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 733: Guanine nucleotide-binding protein alpha-1 subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 C6KIE6 (/IPI) C6KIE6 (/IPI) P18064 (/IPI) P18064 (/IPI) Q0DJ33 (/IPI) Q0DJ33 (/IPI) Q0DJ33 (/IPI)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
4 C6KIE6 (/IDA) C6KIE6 (/IDA) P18064 (/IDA) P18064 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
4 C6KIE6 (/IDA) C6KIE6 (/IDA) P18064 (/IDA) P18064 (/IDA)
GTPase inhibitor activity GO:0005095
Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.
2 P18064 (/IDA) P18064 (/IDA)
Channel regulator activity GO:0016247
Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.
2 P18064 (/IMP) P18064 (/IMP)
GTPase binding GO:0051020
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
2 P18064 (/IPI) P18064 (/IPI)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Brassinosteroid mediated signaling pathway GO:0009742
A series of molecular signals mediated by the detection of brassinosteroid.
3 Q0DJ33 (/IMP) Q0DJ33 (/IMP) Q0DJ33 (/IMP)
Defense response signaling pathway, resistance gene-dependent GO:0009870
A series of molecular signals that depends upon R-genes and is activated during defense response.
3 Q0DJ33 (/IMP) Q0DJ33 (/IMP) Q0DJ33 (/IMP)
Gibberellin mediated signaling pathway GO:0010476
The series of molecular signals generated as a consequence of gibberellin stimulus.
3 Q0DJ33 (/IMP) Q0DJ33 (/IMP) Q0DJ33 (/IMP)
Positive regulation of developmental growth GO:0048639
Any process that activates, maintains or increases the rate of developmental growth.
3 Q0DJ33 (/IMP) Q0DJ33 (/IMP) Q0DJ33 (/IMP)
Tyrosine biosynthetic process GO:0006571
The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
2 P18064 (/IMP) P18064 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P18064 (/IMP) P18064 (/IMP)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
2 P18064 (/IMP) P18064 (/IMP)
L-phenylalanine biosynthetic process GO:0009094
The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.
2 P18064 (/IMP) P18064 (/IMP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
2 C6KIE6 (/IEP) C6KIE6 (/IEP)
Abscisic acid-activated signaling pathway GO:0009738
A series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription.
2 P18064 (/IMP) P18064 (/IMP)
Abscisic acid-activated signaling pathway GO:0009738
A series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription.
2 P18064 (/TAS) P18064 (/TAS)
Gibberellic acid mediated signaling pathway GO:0009740
A series of molecular signals mediated by the detection of gibberellic acid.
2 P18064 (/IMP) P18064 (/IMP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
2 P18064 (/IGI) P18064 (/IGI)
Blue light signaling pathway GO:0009785
The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm.
2 P18064 (/IMP) P18064 (/IMP)
Negative regulation of abscisic acid-activated signaling pathway GO:0009788
Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling.
2 P18064 (/IMP) P18064 (/IMP)
Positive regulation of abscisic acid-activated signaling pathway GO:0009789
Any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling.
2 P18064 (/IMP) P18064 (/IMP)
Seed germination GO:0009845
The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis.
2 P18064 (/IEP) P18064 (/IEP)
Seed germination GO:0009845
The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis.
2 P18064 (/IMP) P18064 (/IMP)
Thylakoid membrane organization GO:0010027
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane.
2 P18064 (/IMP) P18064 (/IMP)
Regulation of stomatal movement GO:0010119
Any process that modulates the frequency, rate or extent of stomatal movement.
2 P18064 (/IMP) P18064 (/IMP)
Regulation of stomatal movement GO:0010119
Any process that modulates the frequency, rate or extent of stomatal movement.
2 P18064 (/TAS) P18064 (/TAS)
Response to low fluence blue light stimulus by blue low-fluence system GO:0010244
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes.
2 P18064 (/IMP) P18064 (/IMP)
Response to pheromone GO:0019236
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.
2 P18064 (/IMP) P18064 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 P18064 (/IMP) P18064 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 C6KIE6 (/IMP) C6KIE6 (/IMP)
Cellular response to abscisic acid stimulus GO:0071215
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
2 P18064 (/IEP) P18064 (/IEP)
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
2 P18064 (/IMP) P18064 (/IMP)
Regulation of stomatal closure GO:0090333
Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange.
2 P18064 (/IMP) P18064 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P18064 (/IDA) P18064 (/IDA) Q0DJ33 (/IDA) Q0DJ33 (/IDA) Q0DJ33 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 C6KIE6 (/IDA) C6KIE6 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 P18064 (/IDA) P18064 (/IDA)
Heterotrimeric G-protein complex GO:0005834
Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
2 P18064 (/IDA) P18064 (/IDA)
Heterotrimeric G-protein complex GO:0005834
Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
2 P18064 (/TAS) P18064 (/TAS)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
2 P18064 (/IDA) P18064 (/IDA)