The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 677: ATP-dependent RNA helicase A
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 105 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
7 | O70133 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
7 | O70133 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
7 | O70133 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Nucleoside-triphosphatase activity GO:0017111
Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
|
7 | O70133 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
3'-5' DNA helicase activity GO:0043138
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'.
|
7 | O70133 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
6 | O70133 (/ISS) P24785 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
6 | O70133 (/ISS) P24785 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Regulatory region RNA binding GO:0001069
Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
|
5 | O70133 (/IDA) P24785 (/IDA) Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
5 | O70133 (/ISS) P24785 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
DNA replication origin binding GO:0003688
Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
3'-5' DNA/RNA helicase activity GO:0033679
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 3' to 5'.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
3'-5' RNA helicase activity GO:0034458
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
RNA stem-loop binding GO:0035613
Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Triplex DNA binding GO:0045142
Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Nucleoside-triphosphate diphosphatase activity GO:0047429
Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Importin-alpha family protein binding GO:0061676
Interacting selectively and non-covalently with any member of the importin-alpha family.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
RNA polymerase binding GO:0070063
Interacting selectively and non-covalently with an RNA polymerase molecule or complex.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
RISC complex binding GO:1905172
Interacting selectively and non-covalently with a RISC complex.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Polysome binding GO:1905538
Interacting selectively and non-covalently with a polysome.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Single-stranded 3'-5' DNA helicase activity GO:1990518
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
4 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) Q28141 (/IDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
4 | O70133 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
4 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) Q28141 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | O70133 (/IPI) Q08211 (/IPI) Q08211 (/IPI) Q08211 (/IPI) |
|
3'-5' DNA helicase activity GO:0043138
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'.
|
4 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) Q28141 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
RNA polymerase II complex binding GO:0000993
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
3 | Q08211 (/IPI) Q08211 (/IPI) Q08211 (/IPI) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
3 | Q08211 (/TAS) Q08211 (/TAS) Q08211 (/TAS) |
|
DNA replication origin binding GO:0003688
Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
3 | Q08211 (/HDA) Q08211 (/HDA) Q08211 (/HDA) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
3 | Q08211 (/TAS) Q08211 (/TAS) Q08211 (/TAS) |
|
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
3'-5' DNA/RNA helicase activity GO:0033679
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 3' to 5'.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
3'-5' RNA helicase activity GO:0034458
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
SiRNA binding GO:0035197
Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
RNA stem-loop binding GO:0035613
Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Triplex DNA binding GO:0045142
Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Nucleoside-triphosphate diphosphatase activity GO:0047429
Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Importin-alpha family protein binding GO:0061676
Interacting selectively and non-covalently with any member of the importin-alpha family.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
RNA polymerase binding GO:0070063
Interacting selectively and non-covalently with an RNA polymerase molecule or complex.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
RISC complex binding GO:1905172
Interacting selectively and non-covalently with a RISC complex.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Polysome binding GO:1905538
Interacting selectively and non-covalently with a polysome.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Single-stranded 3'-5' DNA helicase activity GO:1990518
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | O70133 (/ISO) |
|
RNA polymerase II complex binding GO:0000993
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
|
1 | O70133 (/ISO) |
|
Regulatory region RNA binding GO:0001069
Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
|
1 | O70133 (/ISO) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
1 | O70133 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q28141 (/IDA) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
1 | O70133 (/ISO) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | P24785 (/IDA) |
|
DNA replication origin binding GO:0003688
Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
|
1 | O70133 (/ISO) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
1 | O70133 (/ISO) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
1 | O70133 (/ISO) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
1 | O70133 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | O70133 (/ISO) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | P24785 (/IPI) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | O70133 (/ISO) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
1 | O70133 (/ISO) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
1 | P24785 (/NAS) |
|
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
1 | O70133 (/ISO) |
|
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
|
1 | O70133 (/ISO) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
1 | O70133 (/ISO) |
|
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
1 | P24785 (/ISS) |
|
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
1 | P24785 (/TAS) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | O70133 (/ISO) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
1 | Q28141 (/IDA) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
1 | O70133 (/ISO) |
|
Nucleoside-triphosphatase activity GO:0017111
Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
|
1 | Q28141 (/IDA) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
1 | O70133 (/ISO) |
|
3'-5' DNA/RNA helicase activity GO:0033679
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 3' to 5'.
|
1 | O70133 (/ISO) |
|
3'-5' RNA helicase activity GO:0034458
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'.
|
1 | O70133 (/ISO) |
|
SiRNA binding GO:0035197
Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
|
1 | O70133 (/ISO) |
|
RNA stem-loop binding GO:0035613
Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.
|
1 | O70133 (/ISO) |
|
3'-5' DNA helicase activity GO:0043138
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'.
|
1 | O70133 (/ISO) |
|
Triplex DNA binding GO:0045142
Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination.
|
1 | O70133 (/ISO) |
|
Nucleoside-triphosphate diphosphatase activity GO:0047429
Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.
|
1 | O70133 (/ISO) |
|
Importin-alpha family protein binding GO:0061676
Interacting selectively and non-covalently with any member of the importin-alpha family.
|
1 | O70133 (/ISO) |
|
RNA polymerase binding GO:0070063
Interacting selectively and non-covalently with an RNA polymerase molecule or complex.
|
1 | O70133 (/ISO) |
|
RISC complex binding GO:1905172
Interacting selectively and non-covalently with a RISC complex.
|
1 | O70133 (/ISO) |
|
Polysome binding GO:1905538
Interacting selectively and non-covalently with a polysome.
|
1 | O70133 (/ISO) |
|
Single-stranded 3'-5' DNA helicase activity GO:1990518
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'.
|
1 | O70133 (/ISO) |
|
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
|
1 | O70133 (/ISO) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
1 | O70133 (/ISO) |
There are 115 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
|
8 | O70133 (/ISS) P24785 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Regulation of mRNA processing GO:0050684
Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
|
6 | O70133 (/ISS) P24785 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity GO:2000373
Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity.
|
6 | O70133 (/ISS) P24785 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Regulation of cytoplasmic translation GO:2000765
Any process that modulates the frequency, rate or extent of cytoplasmic translation.
|
6 | O70133 (/ISS) P24785 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
RNA secondary structure unwinding GO:0010501
The process in which a secondary structure of RNA are broken or 'melted'.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Targeting of mRNA for destruction involved in RNA interference GO:0030423
The process in which small interfering RNAs target cognate mRNA molecules for degradation.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
G-quadruplex DNA unwinding GO:0044806
The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Positive regulation of RNA export from nucleus GO:0046833
Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Small RNA loading onto RISC GO:0070922
The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Positive regulation of polysome binding GO:1905698
Any process that activates or increases the frequency, rate or extent of polysome binding.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Positive regulation of cytoplasmic translation GO:2000767
Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
|
4 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) Q28141 (/IDA) |
|
Positive regulation of interferon-beta secretion GO:0035549
Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion.
|
4 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
4 | P24785 (/IMP) Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of response to cytokine stimulus GO:0060760
Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.
|
4 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) |
|
Cellular response to exogenous dsRNA GO:0071360
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
4 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) |
|
Positive regulation of interferon-alpha secretion GO:1902741
Any process that activates or increases the frequency, rate or extent of interferon-alpha secretion.
|
4 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) |
|
Positive regulation of tumor necrosis factor secretion GO:1904469
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.
|
4 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) |
|
Positive regulation of interleukin-6 secretion GO:2000778
Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.
|
4 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) |
|
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
3 | Q08211 (/TAS) Q08211 (/TAS) Q08211 (/TAS) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
3 | Q08211 (/HDA) Q08211 (/HDA) Q08211 (/HDA) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
RNA secondary structure unwinding GO:0010501
The process in which a secondary structure of RNA are broken or 'melted'.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Targeting of mRNA for destruction involved in RNA interference GO:0030423
The process in which small interfering RNAs target cognate mRNA molecules for degradation.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
3 | Q08211 (/TAS) Q08211 (/TAS) Q08211 (/TAS) |
|
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of interleukin-18 production GO:0032741
Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.
|
3 | Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) |
|
Cellular protein-containing complex assembly GO:0034622
The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Positive regulation of interferon-beta secretion GO:0035549
Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
DNA-templated viral transcription GO:0039695
A transcription process that uses a viral DNA as a template.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
G-quadruplex DNA unwinding GO:0044806
The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
|
3 | Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) |
|
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of RNA export from nucleus GO:0046833
Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of viral transcription GO:0050434
Any process that activates or increases the frequency, rate or extent of viral transcription.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Regulation of mRNA processing GO:0050684
Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Regulation of defense response to virus by host GO:0050691
Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.
|
3 | Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) |
|
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
3 | Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of response to cytokine stimulus GO:0060760
Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Pyroptosis GO:0070269
A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.
|
3 | Q08211 (/ISS) Q08211 (/ISS) Q08211 (/ISS) |
|
Small RNA loading onto RISC GO:0070922
The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
CRD-mediated mRNA stabilization GO:0070934
An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Cellular response to exogenous dsRNA GO:0071360
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of interferon-alpha secretion GO:1902741
Any process that activates or increases the frequency, rate or extent of interferon-alpha secretion.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of tumor necrosis factor secretion GO:1904469
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of viral translation GO:1904973
Any process that activates or increases the frequency, rate or extent of viral translation.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of polysome binding GO:1905698
Any process that activates or increases the frequency, rate or extent of polysome binding.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity GO:2000373
Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Regulation of cytoplasmic translation GO:2000765
Any process that modulates the frequency, rate or extent of cytoplasmic translation.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Positive regulation of cytoplasmic translation GO:2000767
Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Positive regulation of interleukin-6 secretion GO:2000778
Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
|
1 | O70133 (/ISO) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | O70133 (/ISO) |
|
Dosage compensation GO:0007549
Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.
|
1 | P24785 (/IDA) |
|
Dosage compensation GO:0007549
Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.
|
1 | P24785 (/IMP) |
|
Dosage compensation GO:0007549
Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.
|
1 | P24785 (/TAS) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | O70133 (/IMP) |
|
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
1 | P24785 (/IMP) |
|
Dosage compensation by hyperactivation of X chromosome GO:0009047
Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster.
|
1 | P24785 (/NAS) |
|
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
1 | B0S6Z1 (/IGI) |
|
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
1 | B0S6Z1 (/IMP) |
|
RNA secondary structure unwinding GO:0010501
The process in which a secondary structure of RNA are broken or 'melted'.
|
1 | O70133 (/ISO) |
|
Dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome GO:0016457
The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster.
|
1 | P24785 (/TAS) |
|
Targeting of mRNA for destruction involved in RNA interference GO:0030423
The process in which small interfering RNAs target cognate mRNA molecules for degradation.
|
1 | O70133 (/ISO) |
|
Positive regulation of heterochromatin assembly GO:0031453
Any process that activates or increases the frequency, rate or extent of heterochromatin formation.
|
1 | P24785 (/IGI) |
|
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
|
1 | O70133 (/ISO) |
|
Positive regulation of interleukin-18 production GO:0032741
Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.
|
1 | O70133 (/IMP) |
|
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
1 | O70133 (/IDA) |
|
Positive regulation of interferon-beta secretion GO:0035549
Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion.
|
1 | O70133 (/ISO) |
|
DNA-templated viral transcription GO:0039695
A transcription process that uses a viral DNA as a template.
|
1 | O70133 (/ISO) |
|
G-quadruplex DNA unwinding GO:0044806
The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.
|
1 | O70133 (/ISO) |
|
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
|
1 | O70133 (/IMP) |
|
Male courtship behavior, veined wing generated song production GO:0045433
The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.
|
1 | P24785 (/IGI) |
|
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
|
1 | O70133 (/ISO) |
|
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
|
1 | O70133 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | O70133 (/ISO) |
|
Positive regulation of RNA export from nucleus GO:0046833
Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm.
|
1 | O70133 (/ISO) |
|
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
|
1 | O70133 (/ISO) |
|
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
|
1 | P24785 (/IMP) |
|
Positive regulation of viral transcription GO:0050434
Any process that activates or increases the frequency, rate or extent of viral transcription.
|
1 | O70133 (/ISO) |
|
Regulation of mRNA processing GO:0050684
Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
|
1 | O70133 (/ISO) |
|
Regulation of defense response to virus by host GO:0050691
Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.
|
1 | O70133 (/IMP) |
|
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
1 | O70133 (/IMP) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | O70133 (/ISO) |
|
Positive regulation of response to cytokine stimulus GO:0060760
Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.
|
1 | O70133 (/ISO) |
|
Pyroptosis GO:0070269
A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.
|
1 | O70133 (/IMP) |
|
Small RNA loading onto RISC GO:0070922
The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA.
|
1 | O70133 (/ISO) |
|
CRD-mediated mRNA stabilization GO:0070934
An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
|
1 | O70133 (/ISO) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | O70133 (/ISO) |
|
Cellular response to exogenous dsRNA GO:0071360
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
1 | O70133 (/ISO) |
|
Positive regulation of interferon-alpha secretion GO:1902741
Any process that activates or increases the frequency, rate or extent of interferon-alpha secretion.
|
1 | O70133 (/ISO) |
|
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
|
1 | O70133 (/ISO) |
|
Positive regulation of tumor necrosis factor secretion GO:1904469
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.
|
1 | O70133 (/ISO) |
|
Positive regulation of viral translation GO:1904973
Any process that activates or increases the frequency, rate or extent of viral translation.
|
1 | O70133 (/ISO) |
|
Positive regulation of polysome binding GO:1905698
Any process that activates or increases the frequency, rate or extent of polysome binding.
|
1 | O70133 (/ISO) |
|
Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity GO:2000373
Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity.
|
1 | O70133 (/ISO) |
|
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
|
1 | O70133 (/ISO) |
|
Regulation of cytoplasmic translation GO:2000765
Any process that modulates the frequency, rate or extent of cytoplasmic translation.
|
1 | O70133 (/ISO) |
|
Positive regulation of cytoplasmic translation GO:2000767
Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.
|
1 | O70133 (/ISO) |
|
Positive regulation of interleukin-6 secretion GO:2000778
Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.
|
1 | O70133 (/ISO) |
There are 60 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
6 | O70133 (/ISS) P24785 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Perichromatin fibrils GO:0005726
Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Polysome GO:0005844
A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
RISC-loading complex GO:0070578
A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
CRD-mediated mRNA stability complex GO:0070937
A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
|
5 | O70133 (/ISS) Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | P24785 (/IDA) Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q28141 (/ISS) Q5R874 (/ISS) Q5R874 (/ISS) Q68FK8 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q08211 (/TAS) Q08211 (/TAS) Q08211 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q08211 (/TAS) Q08211 (/TAS) Q08211 (/TAS) |
|
Perichromatin fibrils GO:0005726
Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q08211 (/TAS) Q08211 (/TAS) Q08211 (/TAS) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q08211 (/TAS) Q08211 (/TAS) Q08211 (/TAS) |
|
Polysome GO:0005844
A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | Q08211 (/HDA) Q08211 (/HDA) Q08211 (/HDA) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
RISC-loading complex GO:0070578
A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
CRD-mediated mRNA stability complex GO:0070937
A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
3 | Q08211 (/IDA) Q08211 (/IDA) Q08211 (/IDA) |
|
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
3 | Q08211 (/IMP) Q08211 (/IMP) Q08211 (/IMP) |
|
Nuclear chromosome GO:0000228
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
|
1 | P24785 (/IDA) |
|
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
1 | P24785 (/IDA) |
|
X chromosome GO:0000805
The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.
|
1 | P24785 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O70133 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | O70133 (/ISO) |
|
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
|
1 | P24785 (/IDA) |
|
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
|
1 | P24785 (/IDA) |
|
Perichromatin fibrils GO:0005726
Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts.
|
1 | O70133 (/ISO) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | O70133 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O70133 (/ISO) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
1 | O70133 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P24785 (/IDA) |
|
Polysome GO:0005844
A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.
|
1 | O70133 (/ISO) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | O70133 (/ISO) |
|
X chromosome located dosage compensation complex, transcription activating GO:0016456
An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster.
|
1 | P24785 (/NAS) |
|
X chromosome located dosage compensation complex, transcription activating GO:0016456
An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster.
|
1 | P24785 (/TAS) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | O70133 (/ISO) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | O70133 (/ISO) |
|
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
|
1 | O70133 (/ISO) |
|
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
|
1 | O70133 (/ISO) |
|
RISC-loading complex GO:0070578
A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
|
1 | O70133 (/ISO) |
|
CRD-mediated mRNA stability complex GO:0070937
A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.
|
1 | O70133 (/ISO) |
|
MSL complex GO:0072487
A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.
|
1 | P24785 (/IDA) |
|
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
|
1 | O70133 (/ISO) |
|
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
1 | O70133 (/ISO) |