The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 562: Structural maintenance of chromosomes protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
23 |
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
(13 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
23 |
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
(13 more) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
18 |
Q14683 (/HDA)
Q14683 (/HDA)
Q14683 (/HDA)
Q14683 (/HDA)
Q14683 (/HDA)
Q14683 (/HDA)
Q14683 (/HDA)
Q14683 (/HDA)
Q14683 (/HDA)
Q14683 (/HDA)
(8 more) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
18 |
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
Q14683 (/IPI)
(8 more) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
7 | O93308 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9N6I4 (/ISS) Q9VCD8 (/ISS) Q9Z1M9 (/ISS) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Mediator complex binding GO:0036033
Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
|
3 | Q9CU62 (/IDA) Q9CU62 (/IDA) Q9CU62 (/IDA) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q920F6 (/IDA) Q920F6 (/IDA) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q9N6I4 (/ISS) Q9VCD8 (/ISS) |
There are 27 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
|
22 |
O93308 (/ISS)
Q14683 (/ISS)
Q14683 (/ISS)
Q14683 (/ISS)
Q14683 (/ISS)
Q14683 (/ISS)
Q14683 (/ISS)
Q14683 (/ISS)
Q14683 (/ISS)
Q14683 (/ISS)
(12 more) |
|
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
|
18 |
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
(8 more) |
|
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
18 |
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
(8 more) |
|
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
|
18 |
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
(8 more) |
|
Mitotic sister chromatid cohesion GO:0007064
The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.
|
18 |
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
(8 more) |
|
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
|
18 |
Q14683 (/IEP)
Q14683 (/IEP)
Q14683 (/IEP)
Q14683 (/IEP)
Q14683 (/IEP)
Q14683 (/IEP)
Q14683 (/IEP)
Q14683 (/IEP)
Q14683 (/IEP)
Q14683 (/IEP)
(8 more) |
|
Negative regulation of DNA endoreduplication GO:0032876
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.
|
18 |
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
(8 more) |
|
Response to DNA damage checkpoint signaling GO:0072423
A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling.
|
18 |
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
(8 more) |
|
Regulation of mitotic spindle assembly GO:1901673
Any process that modulates the frequency, rate or extent of mitotic spindle assembly.
|
18 |
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
Q14683 (/IMP)
(8 more) |
|
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
|
5 | O93308 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9Z1M9 (/ISS) |
|
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
|
5 | Q920F6 (/IPI) Q920F6 (/IPI) Q9CU62 (/IPI) Q9CU62 (/IPI) Q9CU62 (/IPI) |
|
Response to DNA damage checkpoint signaling GO:0072423
A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling.
|
5 | O93308 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9Z1M9 (/ISS) |
|
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
|
3 | Q9CU62 (/IMP) Q9CU62 (/IMP) Q9CU62 (/IMP) |
|
Negative regulation of DNA endoreduplication GO:0032876
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Response to DNA damage checkpoint signaling GO:0072423
A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Regulation of mitotic spindle assembly GO:1901673
Any process that modulates the frequency, rate or extent of mitotic spindle assembly.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
|
2 | Q920F6 (/IDA) Q920F6 (/IDA) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q9N6I4 (/IGI) Q9VCD8 (/IGI) |
|
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
|
2 | Q9N6I4 (/IMP) Q9VCD8 (/IMP) |
|
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
|
2 | Q9N6I4 (/IMP) Q9VCD8 (/IMP) |
|
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
|
2 | Q9N6I4 (/IMP) Q9VCD8 (/IMP) |
|
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
|
1 | Q8AWB7 (/TAS) |
|
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
1 | E7F0X6 (/IMP) |
|
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
|
1 | E7F0X6 (/IGI) |
|
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
|
1 | Q9Z1M9 (/IDA) |
There are 33 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
24 |
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
(14 more) |
|
Meiotic cohesin complex GO:0030893
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
|
24 |
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
(14 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
23 |
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
(13 more) |
|
Cohesin complex GO:0008278
A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
|
23 |
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
(13 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
22 |
G8JLG1 (/IDA)
G8JLG1 (/IDA)
G8JLG1 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
(12 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
22 |
G8JLG1 (/IDA)
G8JLG1 (/IDA)
G8JLG1 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
(12 more) |
|
Chromosome, centromeric region GO:0000775
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
|
18 |
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
(8 more) |
|
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
18 |
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
(8 more) |
|
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
|
18 |
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
(8 more) |
|
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
|
18 |
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
(8 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
18 |
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
(8 more) |
|
Cohesin complex GO:0008278
A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
|
18 |
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
Q14683 (/TAS)
(8 more) |
|
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
18 |
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
(8 more) |
|
Mitotic spindle pole GO:0097431
Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
|
18 |
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
Q14683 (/IDA)
(8 more) |
|
Meiotic cohesin complex GO:0030893
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
|
7 | O93308 (/ISS) Q920F6 (/ISS) Q920F6 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9Z1M9 (/ISS) |
|
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
5 | O93308 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9Z1M9 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | O93308 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9CU62 (/ISS) Q9Z1M9 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
5 | Q920F6 (/ISO) Q920F6 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | Q920F6 (/ISO) Q920F6 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Meiotic cohesin complex GO:0030893
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
|
5 | Q920F6 (/ISO) Q920F6 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Cohesin complex GO:0008278
A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Mitotic spindle pole GO:0097431
Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
|
3 | Q9CU62 (/ISO) Q9CU62 (/ISO) Q9CU62 (/ISO) |
|
Chromosome, centromeric region GO:0000775
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
|
2 | Q920F6 (/IDA) Q920F6 (/IDA) |
|
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
|
2 | Q920F6 (/IDA) Q920F6 (/IDA) |
|
Synaptonemal complex GO:0000795
A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element.
|
2 | Q920F6 (/IDA) Q920F6 (/IDA) |
|
Lateral element GO:0000800
A proteinaceous core found between sister chromatids during meiotic prophase.
|
2 | Q920F6 (/IDA) Q920F6 (/IDA) |
|
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
|
2 | Q9N6I4 (/IDA) Q9VCD8 (/IDA) |
|
Cohesin complex GO:0008278
A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
|
2 | Q9N6I4 (/NAS) Q9VCD8 (/NAS) |
|
Nuclear meiotic cohesin complex GO:0034991
A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
|
2 | Q920F6 (/IDA) Q920F6 (/IDA) |
|
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
|
2 | Q9N6I4 (/IDA) Q9VCD8 (/IDA) |