The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Dynein heavy chain 5, axonemal

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ATP-dependent microtubule motor activity, minus-end-directed GO:0008569
Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP.
15 A0A0B4K614 (/ISS) A0A0B4K648 (/ISS) A0A0B4KI48 (/ISS) A0A0B4LH20 (/ISS) A0A0U1RVI8 (/ISS) A8Y5B7 (/ISS) E1JJ04 (/ISS) Q5LJP0 (/ISS) Q9GPN7 (/ISS) Q9GPN8 (/ISS)
(5 more)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
5 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q96JB1 (/NAS) Q9P225 (/NAS) Q9P2D7 (/NAS)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
5 A0A0U1RVI8 (/ISS) A8Y5B7 (/ISS) Q5LJP0 (/ISS) Q9GPN7 (/ISS) Q9GPN8 (/ISS)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
5 A0A0U1RVI8 (/TAS) A8Y5B7 (/TAS) Q5LJP0 (/TAS) Q9GPN7 (/TAS) Q9GPN8 (/TAS)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
4 D3YYQ8 (/IC) E9Q8T7 (/IC) F7ABZ6 (/IC) Q8WXX0 (/IC)
Dynein light chain binding GO:0045503
Interacting selectively and non-covalently with a light chain of the dynein complex.
4 A8I3X6 (/IPI) A8I5C3 (/IPI) A8ISA6 (/IPI) Q4AC22 (/IPI)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
3 Q9MBF8 (/IDA) Q9MBF8 (/IDA) Q9SMH3 (/IDA)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
3 Q38B68 (/ISM) Q38B68 (/ISM) Q57YY8 (/ISM)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
3 Q9MBF8 (/IDA) Q9MBF8 (/IDA) Q9SMH3 (/IDA)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 Q8VHE6 (/IMP)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q4AC22 (/IDA)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
15 A0A0B4K614 (/ISS) A0A0B4K648 (/ISS) A0A0B4KI48 (/ISS) A0A0B4LH20 (/ISS) A0A0U1RVI8 (/ISS) A8Y5B7 (/ISS) E1JJ04 (/ISS) Q5LJP0 (/ISS) Q9GPN7 (/ISS) Q9GPN8 (/ISS)
(5 more)
Cilium movement involved in cell motility GO:0060294
Movement of cilia mediated by motor proteins that contributes to the movement of a cell.
6 E9Q8T7 (/IMP) Q39575 (/IMP) Q4AC22 (/IMP) Q9MBF8 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
5 A0A0B4K614 (/IMP) A0A0B4K648 (/IMP) A0A0B4LH20 (/IMP) Q9VH97 (/IMP) Q9VJC6 (/IMP)
Inner dynein arm assembly GO:0036159
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
5 Q4AC22 (/IMP) Q8WXX0 (/IMP) Q9MBF8 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Cilium-dependent cell motility GO:0060285
Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
5 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q96JB1 (/NAS) Q9P225 (/NAS) Q9P2D7 (/NAS)
Cilium movement involved in cell motility GO:0060294
Movement of cilia mediated by motor proteins that contributes to the movement of a cell.
4 Q4AC22 (/IGI) Q9MBF8 (/IGI) Q9MBF8 (/IGI) Q9SMH3 (/IGI)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
3 Q8TE73 (/IMP) Q8VHE6 (/IMP) Q8WXX0 (/IMP)
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
3 Q38B68 (/ISM) Q38B68 (/ISM) Q57YY8 (/ISM)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
3 E9Q8T7 (/IMP) Q8TE73 (/IMP) Q9P2D7 (/IMP)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
2 D3YYQ8 (/IC) F7ABZ6 (/IC)
Epithelial cilium movement involved in extracellular fluid movement GO:0003351
The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
2 E9Q8T7 (/IMP) Q8VHE6 (/IMP)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
2 Q8TE73 (/IMP) Q8VHE6 (/IMP)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
2 E9Q8T7 (/ISO) Q8VHE6 (/ISO)
Outer dynein arm assembly GO:0036158
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
2 Q39575 (/IMP) Q8TE73 (/IMP)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
1 Q8VHE6 (/ISO)
Sperm axoneme assembly GO:0007288
The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
1 Q9P2D7 (/IMP)
Sperm axoneme assembly GO:0007288
The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
1 E9Q8T7 (/ISO)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
1 Q8VHE6 (/ISO)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q8VHE6 (/IMP)
Response to auditory stimulus GO:0010996
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus.
1 Q9VZ77 (/IMP)
Lateral ventricle development GO:0021670
The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.
1 Q8VHE6 (/IMP)
Outer dynein arm assembly GO:0036158
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
1 Q8VHE6 (/ISO)
Inner dynein arm assembly GO:0036159
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
1 Q9P2D7 (/IDA)
Inner dynein arm assembly GO:0036159
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
1 E9Q8T7 (/ISO)
Sperm competition GO:0046692
Any process that contributes to the success of sperm fertilization in multiply-mated females.
1 Q9VZ77 (/IMP)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 Q8TE73 (/IMP)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 Q8VHE6 (/ISO)
Determination of heart left/right asymmetry GO:0061371
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
1 K7DY80 (/IGI)

There are 32 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
10 Q38B68 (/IDA) Q38B68 (/IDA) Q57WX6 (/IDA) Q57WX6 (/IDA) Q57YY8 (/IDA) Q580B5 (/IDA) Q8TE73 (/IDA) Q8VHE6 (/IDA) Q9MBF8 (/IDA) Q9MBF8 (/IDA)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
9 A0A0B4KI48 (/ISS) A0A0U1RVI8 (/ISS) E1JJ04 (/ISS) Q5LJP0 (/ISS) Q9GPN8 (/ISS) Q9VAV5 (/ISS) Q9VJC6 (/ISS) Q9VWZ3 (/ISS) Q9VZ77 (/ISS)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
7 E9Q8T7 (/ISO) Q4Q1Y1 (/ISO) Q4Q2F4 (/ISO) Q4Q8K9 (/ISO) Q4Q9Z6 (/ISO) Q4QB21 (/ISO) Q8VHE6 (/ISO)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
7 D3YYQ8 (/ISM) E9Q0T8 (/ISM) E9Q8T7 (/ISM) F7ABZ6 (/ISM) P0C6F1 (/ISM) P0C6F1 (/ISM) Q8BW94 (/ISM)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
6 A8I3X6 (/IMP) Q4AC22 (/IMP) Q8WXX0 (/IMP) Q9MBF8 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
6 A0A0B4K614 (/ISS) A0A0B4K648 (/ISS) A0A0B4LH20 (/ISS) A8Y5B7 (/ISS) Q9GPN7 (/ISS) Q9VH97 (/ISS)
Axonemal dynein complex GO:0005858
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
5 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q96JB1 (/NAS) Q9P225 (/NAS) Q9P2D7 (/NAS)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
5 Q4AC22 (/IDA) Q9MBF8 (/IDA) Q9MBF8 (/IDA) Q9P2D7 (/IDA) Q9SMH3 (/IDA)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
4 Q57WX6 (/IDA) Q57WX6 (/IDA) Q57YY8 (/IDA) Q8WXX0 (/IDA)
Axonemal dynein complex GO:0005858
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
3 A8Y5B7 (/IMP) Q8VHE6 (/IMP) Q9GPN7 (/IMP)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
3 Q38B68 (/ISM) Q38B68 (/ISM) Q57YY8 (/ISM)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
3 A0A0U1RVI8 (/TAS) Q5LJP0 (/TAS) Q9GPN8 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q38B68 (/IDA) Q38B68 (/IDA)
Intraciliary transport particle GO:0030990
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
2 Q38B68 (/IDA) Q38B68 (/IDA)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
2 P0C6F1 (/IDA) P0C6F1 (/IDA)
Sperm flagellum GO:0036126
A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
2 E9Q8T7 (/IDA) Q9P2D7 (/IDA)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
2 E9Q0T8 (/ISO) E9Q8T7 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q4Q1Y1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8WXX0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 E9Q0T8 (/ISO)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 E9Q0T8 (/ISO)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
1 Q9P2D7 (/IMP)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
1 Q96JB1 (/IDA)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
1 Q91XQ0 (/ISO)
Intraciliary transport particle GO:0030990
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
1 Q4Q1Y1 (/ISO)
Sperm flagellum GO:0036126
A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
1 E9Q8T7 (/ISO)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 Q8TE73 (/IDA)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 Q8TE73 (/IMP)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 Q91XQ0 (/ISM)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 Q8VHE6 (/ISO)
9+2 motile cilium GO:0097729
A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
1 Q8TE73 (/IDA)
9+2 motile cilium GO:0097729
A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
1 Q8VHE6 (/ISO)