The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 431: Regulator of telomere elongation helicase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
21 A4K436 (/ISS) B0W9F4 (/ISS) B3MSG8 (/ISS) B3NSW1 (/ISS) B4GU19 (/ISS) B4I0K4 (/ISS) B4JNS2 (/ISS) B4L1Z2 (/ISS) B4M891 (/ISS) B4NDG5 (/ISS)
(11 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
20 A4K436 (/ISS) B0W9F4 (/ISS) B3MSG8 (/ISS) B3NSW1 (/ISS) B4GU19 (/ISS) B4I0K4 (/ISS) B4JNS2 (/ISS) B4L1Z2 (/ISS) B4M891 (/ISS) B4NDG5 (/ISS)
(10 more)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
2 Q0VGM9 (/ISO) Q6H1L8 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q0VGM9 (/IPI) Q9NZ71 (/IPI)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q0VGM9 (/ISO) Q6H1L8 (/ISO)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
1 Q0VGM9 (/IDA)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
1 Q9NZ71 (/IMP)
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
1 Q0VGM9 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9NZ71 (/IMP)
DNA polymerase binding GO:0070182
Interacting selectively and non-covalently with a DNA polymerase.
1 Q0VGM9 (/IPI)

There are 49 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
20 A4K436 (/ISS) B0W9F4 (/ISS) B3MSG8 (/ISS) B3NSW1 (/ISS) B4GU19 (/ISS) B4I0K4 (/ISS) B4JNS2 (/ISS) B4L1Z2 (/ISS) B4M891 (/ISS) B4NDG5 (/ISS)
(10 more)
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
5 A4K436 (/ISS) Q5RE34 (/ISS) Q5RJZ1 (/ISS) Q6H1L8 (/ISS) Q9NZ71 (/ISS)
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
4 F4HQE2 (/IMP) Q0VGM9 (/IMP) Q6H1L8 (/IMP) Q9NZ71 (/IMP)
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
2 Q0VGM9 (/ISO) Q6H1L8 (/ISO)
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
2 F4HQE2 (/IMP) Q9NZ71 (/IMP)
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
2 Q0VGM9 (/ISO) Q6H1L8 (/ISO)
Telomeric loop disassembly GO:0090657
The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication.
2 Q0VGM9 (/IMP) Q9NZ71 (/IMP)
Telomeric loop disassembly GO:0090657
The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication.
2 Q0VGM9 (/ISO) Q6H1L8 (/ISO)
Positive regulation of telomere capping GO:1904355
Any process that activates or increases the frequency, rate or extent of telomere capping.
2 Q0VGM9 (/ISO) Q6H1L8 (/ISO)
Positive regulation of telomere maintenance via telomere lengthening GO:1904358
Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening.
2 Q0VGM9 (/ISO) Q6H1L8 (/ISO)
Negative regulation of t-circle formation GO:1904430
Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation.
2 Q0VGM9 (/IMP) Q9NZ71 (/IMP)
Negative regulation of t-circle formation GO:1904430
Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation.
2 Q0VGM9 (/ISO) Q6H1L8 (/ISO)
Recombinational repair GO:0000725
A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.
1 F4HQE2 (/IMP)
Strand displacement GO:0000732
The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules.
1 Q0VGM9 (/IDA)
Strand displacement GO:0000732
The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules.
1 Q9NZ71 (/ISS)
Strand displacement GO:0000732
The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules.
1 Q9NZ71 (/TAS)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
1 F4HQE2 (/IMP)
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
1 F4HQE2 (/IMP)
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
1 F4HQE2 (/IMP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
1 F4HQE2 (/IGI)
Replication fork processing GO:0031297
The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.
1 Q0VGM9 (/IDA)
Replication fork processing GO:0031297
The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.
1 Q9NZ71 (/ISS)
Positive regulation of telomere maintenance GO:0032206
Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
1 Q0VGM9 (/IMP)
Positive regulation of telomere maintenance GO:0032206
Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
1 Q9NZ71 (/ISS)
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
1 Q0VGM9 (/IDA)
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
1 Q9NZ71 (/ISS)
Interstrand cross-link repair GO:0036297
Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.
1 F4HQE2 (/IMP)
Maintenance of rDNA GO:0043007
Any process involved in sustaining the fidelity and copy number of rDNA repeats.
1 F4HQE2 (/IGI)
Maintenance of rDNA GO:0043007
Any process involved in sustaining the fidelity and copy number of rDNA repeats.
1 F4HQE2 (/IMP)
Telomere maintenance in response to DNA damage GO:0043247
Any process that occur in response to the presence of critically short or damaged telomeres.
1 Q0VGM9 (/IMP)
Telomere maintenance in response to DNA damage GO:0043247
Any process that occur in response to the presence of critically short or damaged telomeres.
1 Q9NZ71 (/ISS)
Negative regulation of DNA recombination GO:0045910
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.
1 Q0VGM9 (/IDA)
Negative regulation of DNA recombination GO:0045910
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.
1 F4HQE2 (/IMP)
Negative regulation of DNA recombination GO:0045910
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.
1 Q9NZ71 (/ISS)
Root development GO:0048364
The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo.
1 F4HQE2 (/IMP)
Telomeric D-loop disassembly GO:0061820
A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus.
1 Q0VGM9 (/TAS)
Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication GO:0070716
A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication.
1 F4HQE2 (/IMP)
Telomeric loop disassembly GO:0090657
The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication.
1 Q0VGM9 (/IDA)
Telomeric loop disassembly GO:0090657
The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication.
1 Q9NZ71 (/ISS)
Mitotic telomere maintenance via semi-conservative replication GO:1902990
Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle.
1 Q0VGM9 (/IDA)
Mitotic telomere maintenance via semi-conservative replication GO:1902990
Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle.
1 Q9NZ71 (/ISS)
Positive regulation of telomere capping GO:1904355
Any process that activates or increases the frequency, rate or extent of telomere capping.
1 Q9NZ71 (/IMP)
Positive regulation of telomere maintenance via telomere lengthening GO:1904358
Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening.
1 Q9NZ71 (/IMP)
Negative regulation of t-circle formation GO:1904430
Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation.
1 Q9NZ71 (/ISS)
Negative regulation of t-circle formation GO:1904430
Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation.
1 Q9NZ71 (/TAS)
Negative regulation of telomere maintenance in response to DNA damage GO:1904506
Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance in response to DNA damage.
1 Q0VGM9 (/IMP)
Negative regulation of telomere maintenance in response to DNA damage GO:1904506
Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance in response to DNA damage.
1 Q9NZ71 (/ISS)
Positive regulation of telomeric loop disassembly GO:1904535
Any process that activates or increases the frequency, rate or extent of telomeric loop disassembly.
1 Q0VGM9 (/IDA)
Positive regulation of telomeric loop disassembly GO:1904535
Any process that activates or increases the frequency, rate or extent of telomeric loop disassembly.
1 Q9NZ71 (/ISS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
20 A4K436 (/ISS) B0W9F4 (/ISS) B3MSG8 (/ISS) B3NSW1 (/ISS) B4GU19 (/ISS) B4I0K4 (/ISS) B4JNS2 (/ISS) B4L1Z2 (/ISS) B4M891 (/ISS) B4NDG5 (/ISS)
(10 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q0VGM9 (/IDA) Q6H1L8 (/IDA) Q9NZ71 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q0VGM9 (/ISO) Q6H1L8 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 F4HQE2 (/IDA) F4HUN4 (/IDA)
Chromosome, telomeric region GO:0000781
The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
1 Q0VGM9 (/IDA)
Chromosome, telomeric region GO:0000781
The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
1 Q9NZ71 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9NZ71 (/TAS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 F4HUN8 (/IDA)