The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 414: ATP-dependent RNA helicase DHX30 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
5 Q2NKY8 (/ISS) Q5BJS0 (/ISS) Q5R607 (/ISS) Q5ZI74 (/ISS) Q99PU8 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
5 Q2NKY8 (/ISS) Q5BJS0 (/ISS) Q5R607 (/ISS) Q5ZI74 (/ISS) Q99PU8 (/ISS)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
5 Q2NKY8 (/ISS) Q5BJS0 (/ISS) Q5R607 (/ISS) Q5ZI74 (/ISS) Q99PU8 (/ISS)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
3 Q7L2E3 (/IDA) Q7L2E3 (/IDA) Q99PU8 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q5BJS0 (/IPI) Q7L2E3 (/IPI) Q7L2E3 (/IPI)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 Q7L2E3 (/IDA) Q7L2E3 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q7L2E3 (/HDA) Q7L2E3 (/HDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q7L2E3 (/IDA) Q7L2E3 (/IDA)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
2 Q7L2E3 (/IDA) Q7L2E3 (/IDA)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
1 Q22307 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q99PU8 (/ISO)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 Q22307 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q99PU8 (/ISO)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
1 Q99PU8 (/ISO)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
1 Q99PU8 (/ISO)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
1 Q22307 (/ISS)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
6 Q2NKY8 (/ISS) Q5BJS0 (/ISS) Q5R607 (/ISS) Q5ZI74 (/ISS) Q7L2E3 (/ISS) Q7L2E3 (/ISS)
Mitochondrial large ribosomal subunit assembly GO:1902775
The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit.
4 Q2NKY8 (/ISS) Q5BJS0 (/ISS) Q5R607 (/ISS) Q99PU8 (/ISS)
Mitochondrial large ribosomal subunit assembly GO:1902775
The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit.
2 Q7L2E3 (/IMP) Q7L2E3 (/IMP)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 Q22307 (/IMP)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 Q99PU8 (/IDA)
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
1 Q22307 (/ISS)
Negative regulation of gene expression, epigenetic GO:0045814
Any epigenetic process that stops, prevents or reduces the rate of gene expression.
1 Q22307 (/IMP)
Mitochondrial large ribosomal subunit assembly GO:1902775
The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit.
1 Q99PU8 (/ISO)
Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity GO:2000373
Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity.
1 Q22307 (/ISS)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q2NKY8 (/ISS) Q5BJS0 (/ISS) Q5R607 (/ISS) Q5ZI74 (/ISS) Q99PU8 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 A0A024R2T6 (/IDA) A0A024R2T6 (/IDA) H7BXY3 (/IDA) Q7L2E3 (/IDA) Q7L2E3 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 Q2NKY8 (/ISS) Q5BJS0 (/ISS) Q5R607 (/ISS) Q5ZI74 (/ISS) Q99PU8 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 A0A024R2T6 (/IDA) A0A024R2T6 (/IDA) H7BXY3 (/IDA) Q7L2E3 (/IDA) Q7L2E3 (/IDA)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
5 Q2NKY8 (/ISS) Q5BJS0 (/ISS) Q5R607 (/ISS) Q5ZI74 (/ISS) Q99PU8 (/ISS)
Ribonucleoprotein granule GO:0035770
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
4 Q2NKY8 (/ISS) Q5BJS0 (/ISS) Q5R607 (/ISS) Q99PU8 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q7L2E3 (/IDA) Q7L2E3 (/IDA) Q99PU8 (/IDA)
Ribonucleoprotein granule GO:0035770
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
2 Q7L2E3 (/IDA) Q7L2E3 (/IDA)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
2 Q7L2E3 (/IDA) Q7L2E3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q99PU8 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q99PU8 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q99PU8 (/ISO)
Ribonucleoprotein granule GO:0035770
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
1 Q99PU8 (/ISO)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
1 Q99PU8 (/ISO)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
1 Q22307 (/ISS)