The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 412: ADP-ribosylation factor 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
14 Q7KQL3 (/IDA) Q7KQL3 (/IDA) Q7KQL3 (/IDA) Q7KQL3 (/IDA) Q7KQL3 (/IDA) Q7KQL3 (/IDA) Q7KQL3 (/IDA) Q7KQL3 (/IDA) Q7KQL3 (/IDA) Q7KQL3 (/IDA)
(4 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 P40994 (/IPI) P40994 (/IPI) P40994 (/IPI) P40994 (/IPI) P40994 (/IPI) P40994 (/IPI) P40994 (/IPI) P40994 (/IPI) P40994 (/IPI) P40994 (/IPI)
(1 more)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
10 P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
10 P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA)
Enzyme regulator activity GO:0030234
Binds to and modulates the activity of an enzyme.
10 P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
7 Q38D64 (/IPI) Q38D64 (/IPI) Q38D64 (/IPI) Q38D64 (/IPI) Q38D65 (/IPI) Q38D65 (/IPI) Q38D65 (/IPI)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 Q9Y7Z2 (/ISS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 Q9Y7Z2 (/ISM)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 Q9SHU5 (/ISS)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
14 Q7KQL3 (/TAS) Q7KQL3 (/TAS) Q7KQL3 (/TAS) Q7KQL3 (/TAS) Q7KQL3 (/TAS) Q7KQL3 (/TAS) Q7KQL3 (/TAS) Q7KQL3 (/TAS) Q7KQL3 (/TAS) Q7KQL3 (/TAS)
(4 more)
Cellular bud site selection GO:0000282
The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae.
10 P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
10 P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
10 P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
10 P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP)
Positive regulation of phosphatidylinositol biosynthetic process GO:0010513
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.
10 P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP)
Invasive filamentous growth GO:0036267
The growth of colonies in filamentous chains of cells into a substrate.
10 P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
10 P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI)
Actin cortical patch localization GO:0051666
Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells.
10 P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI) P40994 (/IGI)
Actin cortical patch localization GO:0051666
Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells.
10 P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP) P40994 (/IMP)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
1 Q9Y7Z2 (/IC)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
1 Q9Y7Z2 (/ISS)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
1 Q9Y7Z2 (/NAS)
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
1 Q94231 (/HEP)
Activation of bipolar cell growth GO:0051519
Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell.
1 Q9Y7Z2 (/IMP)
Cell growth mode switching, monopolar to bipolar GO:0051523
The process in which a cell switches from monopolar cell growth to bipolar cell growth.
1 Q9Y7Z2 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Food vacuole GO:0020020
Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa.
14 Q7KQL3 (/RCA) Q7KQL3 (/RCA) Q7KQL3 (/RCA) Q7KQL3 (/RCA) Q7KQL3 (/RCA) Q7KQL3 (/RCA) Q7KQL3 (/RCA) Q7KQL3 (/RCA) Q7KQL3 (/RCA) Q7KQL3 (/RCA)
(4 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P40994 (/HDA) P40994 (/HDA) P40994 (/HDA) P40994 (/HDA) P40994 (/HDA) P40994 (/HDA) P40994 (/HDA) P40994 (/HDA) P40994 (/HDA) P40994 (/HDA)
Cellular bud tip GO:0005934
The end of a cellular bud distal to the site of attachment to the mother cell.
10 P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
10 P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA) P40994 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q38D64 (/IDA) Q38D64 (/IDA) Q38D64 (/IDA) Q38D64 (/IDA)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
4 Q38D64 (/IDA) Q38D64 (/IDA) Q38D64 (/IDA) Q38D64 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
4 Q38D64 (/IDA) Q38D64 (/IDA) Q38D64 (/IDA) Q38D64 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 Q9Y7Z2 (/ISS)
Division septum GO:0000935
A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
1 Q9Y7Z2 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q9Y7Z2 (/IDA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 Q9Y7Z2 (/IDA)
Cell cortex of cell tip GO:0051285
The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell.
1 Q9Y7Z2 (/IDA)