The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 377: transcriptional regulator ATRX isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | F1MQ85 (/IPI) P46100 (/IPI) Q61687 (/IPI) Q99NG0 (/IPI) Q9Y4B4 (/IPI) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
4 | Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
4 | Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | P46100 (/IDA) Q61687 (/IDA) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
2 | P46100 (/IDA) Q61687 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P46100 (/ISA) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q61687 (/ISO) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
1 | Q99NG0 (/IDA) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q99NG0 (/IDA) |
|
DNA translocase activity GO:0015616
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule.
|
1 | P46100 (/IDA) |
|
DNA translocase activity GO:0015616
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule.
|
1 | Q61687 (/ISO) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
1 | Q99NG0 (/IDA) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q99NG0 (/IPI) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
1 | P46100 (/IDA) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
1 | Q61687 (/ISO) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q61687 (/IPI) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q61687 (/ISO) |
|
Chromo shadow domain binding GO:0070087
Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.
|
1 | P46100 (/IPI) |
|
Chromo shadow domain binding GO:0070087
Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.
|
1 | Q61687 (/ISO) |
There are 45 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
|
5 | Q61687 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
DNA replication-independent nucleosome assembly GO:0006336
The formation of nucleosomes outside the context of DNA replication.
|
5 | Q61687 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
5 | Q61687 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Positive regulation of nuclear cell cycle DNA replication GO:0010571
Any process that activates or increases the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.
|
5 | P46100 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
DNA damage response, signal transduction by p53 class mediator GO:0030330
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
|
5 | P46100 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Replication fork processing GO:0031297
The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.
|
5 | P46100 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Positive regulation of telomere maintenance GO:0032206
Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
|
5 | P46100 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Cellular response to hydroxyurea GO:0072711
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.
|
5 | P46100 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Regulation of histone H3-K9 trimethylation GO:1900112
Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation.
|
5 | Q61687 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Negative regulation of telomeric RNA transcription from RNA pol II promoter GO:1901581
Any process that stops, prevents or reduces the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter.
|
5 | P46100 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
4 | Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Meiotic spindle organization GO:0000212
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
|
1 | Q61687 (/IMP) |
|
DNA methylation GO:0006306
The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
|
1 | P46100 (/TAS) |
|
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
|
1 | P46100 (/IDA) |
|
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
|
1 | Q61687 (/ISO) |
|
DNA replication-independent nucleosome assembly GO:0006336
The formation of nucleosomes outside the context of DNA replication.
|
1 | P46100 (/IMP) |
|
DNA replication-independent nucleosome assembly GO:0006336
The formation of nucleosomes outside the context of DNA replication.
|
1 | Q61687 (/ISO) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | P46100 (/IDA) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | Q61687 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P46100 (/TAS) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | Q61687 (/IMP) |
|
Positive regulation of nuclear cell cycle DNA replication GO:0010571
Any process that activates or increases the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.
|
1 | Q61687 (/IMP) |
|
DNA damage response, signal transduction by p53 class mediator GO:0030330
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
|
1 | Q61687 (/IMP) |
|
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
1 | Q61687 (/IMP) |
|
Replication fork processing GO:0031297
The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.
|
1 | Q61687 (/IMP) |
|
Positive regulation of telomere maintenance GO:0032206
Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
|
1 | Q61687 (/IMP) |
|
Post-embryonic forelimb morphogenesis GO:0035128
The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism.
|
1 | Q61687 (/IMP) |
|
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
|
1 | Q61687 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q99NG0 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q61687 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P46100 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q61687 (/ISO) |
|
Sertoli cell development GO:0060009
The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate.
|
1 | Q61687 (/IMP) |
|
Chromosome organization involved in meiotic cell cycle GO:0070192
A process of chromosome organization that is involved in a meiotic cell cycle.
|
1 | Q61687 (/IMP) |
|
Protein localization to chromosome, telomeric region GO:0070198
Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.
|
1 | Q61687 (/IMP) |
|
Protein localization to chromosome, telomeric region GO:0070198
Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.
|
1 | P46100 (/ISS) |
|
Seminiferous tubule development GO:0072520
The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa.
|
1 | Q61687 (/IMP) |
|
Cellular response to hydroxyurea GO:0072711
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.
|
1 | Q61687 (/IMP) |
|
Regulation of histone H3-K9 trimethylation GO:1900112
Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation.
|
1 | P46100 (/IMP) |
|
Regulation of histone H3-K9 trimethylation GO:1900112
Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation.
|
1 | Q61687 (/ISO) |
|
Negative regulation of telomeric RNA transcription from RNA pol II promoter GO:1901581
Any process that stops, prevents or reduces the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter.
|
1 | Q61687 (/IMP) |
|
Positive regulation of telomeric RNA transcription from RNA pol II promoter GO:1901582
Any process that activates or increases the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter.
|
1 | P46100 (/IMP) |
|
Positive regulation of telomeric RNA transcription from RNA pol II promoter GO:1901582
Any process that activates or increases the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter.
|
1 | Q61687 (/ISO) |
|
Negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric GO:1904908
Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric.
|
1 | P46100 (/IMP) |
|
Negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric GO:1904908
Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric.
|
1 | Q61687 (/ISO) |
There are 24 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Telomeric heterochromatin GO:0031933
Heterochromatic regions of the chromosome found at the telomeres.
|
5 | P46100 (/ISS) Q7YQM3 (/ISS) Q7YQM3 (/ISS) Q7YQM4 (/ISS) Q7YQM4 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q61687 (/IDA) Q99NG0 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | A4LAA3 (/IDA) P46100 (/IDA) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
2 | A4LAA3 (/IDA) P46100 (/IDA) |
|
Nuclear chromosome GO:0000228
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
|
1 | Q61687 (/IDA) |
|
Condensed nuclear chromosome, centromeric region GO:0000780
The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
|
1 | Q61687 (/IDA) |
|
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
1 | Q61687 (/IDA) |
|
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
1 | P46100 (/ISS) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
1 | Q61687 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q61687 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P46100 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q61687 (/ISO) |
|
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
|
1 | P46100 (/TAS) |
|
Pericentric heterochromatin GO:0005721
Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
|
1 | Q61687 (/IDA) |
|
Pericentric heterochromatin GO:0005721
Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
|
1 | P46100 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q61687 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | Q61687 (/ISO) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
1 | Q61687 (/IDA) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
1 | P46100 (/ISS) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q99NG0 (/IDA) |
|
Nuclear pericentric heterochromatin GO:0031618
Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
|
1 | Q61687 (/IDA) |
|
Telomeric heterochromatin GO:0031933
Heterochromatic regions of the chromosome found at the telomeres.
|
1 | Q61687 (/IDA) |
|
Nuclear subtelomeric heterochromatin GO:1990707
Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus.
|
1 | P46100 (/IDA) |
|
Nuclear subtelomeric heterochromatin GO:1990707
Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus.
|
1 | Q61687 (/ISO) |