The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 310: RuvB-like helicase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
45 |
P60122 (/IPI)
P60122 (/IPI)
P60122 (/IPI)
P60122 (/IPI)
P60122 (/IPI)
Q9FMR9 (/IPI)
Q9FMR9 (/IPI)
Q9VH07 (/IPI)
Q9Y265 (/IPI)
Q9Y265 (/IPI)
(35 more) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
37 |
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
(27 more) |
|
TFIID-class transcription factor complex binding GO:0001094
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
|
5 | P60122 (/IPI) P60122 (/IPI) P60122 (/IPI) P60122 (/IPI) P60122 (/IPI) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
5 | P60122 (/IDA) P60122 (/IDA) P60122 (/IDA) P60122 (/IDA) P60122 (/IDA) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
3'-5' DNA helicase activity GO:0043138
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
|
5 | P60122 (/IDA) P60122 (/IDA) P60122 (/IDA) P60122 (/IDA) P60122 (/IDA) |
|
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
|
5 | P60122 (/IPI) P60122 (/IPI) P60122 (/IPI) P60122 (/IPI) P60122 (/IPI) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
2 | Q0IFL2 (/ISS) Q29AK9 (/ISS) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q9VH07 (/IMP) |
There are 34 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
CENP-A containing nucleosome assembly GO:0034080
The formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Histone H2A acetylation GO:0043968
The modification of histone H2A by the addition of an acetyl group.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Beta-catenin-TCF complex assembly GO:1904837
The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
Positive regulation of telomerase RNA localization to Cajal body GO:1904874
Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.
|
37 |
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
Q9Y265 (/HMP)
(27 more) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
10 | P60122 (/ISS) P60122 (/ISS) P60122 (/ISS) P60122 (/ISS) P60122 (/ISS) P60123 (/ISS) P60123 (/ISS) P60123 (/ISS) P60123 (/ISS) P60123 (/ISS) |
|
Histone H2A acetylation GO:0043968
The modification of histone H2A by the addition of an acetyl group.
|
10 | P60122 (/ISS) P60122 (/ISS) P60122 (/ISS) P60122 (/ISS) P60122 (/ISS) P60123 (/ISS) P60123 (/ISS) P60123 (/ISS) P60123 (/ISS) P60123 (/ISS) |
|
Positive regulation of plasminogen activation GO:0010756
Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
|
5 | P60123 (/IDA) P60123 (/IDA) P60123 (/IDA) P60123 (/IDA) P60123 (/IDA) |
|
Positive regulation of plasminogen activation GO:0010756
Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
Histone H2A acetylation GO:0043968
The modification of histone H2A by the addition of an acetyl group.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
Regulation of fibroblast apoptotic process GO:2000269
Any process that modulates the frequency, rate or extent of fibroblast apoptotic process.
|
5 | P60123 (/IMP) P60123 (/IMP) P60123 (/IMP) P60123 (/IMP) P60123 (/IMP) |
|
Regulation of fibroblast apoptotic process GO:2000269
Any process that modulates the frequency, rate or extent of fibroblast apoptotic process.
|
5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
2 | Q0IFL2 (/ISS) Q29AK9 (/ISS) |
|
Meristem development GO:0048507
The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure.
|
2 | Q9FMR9 (/IMP) Q9FMR9 (/IMP) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
2 | Q0IFL2 (/ISS) Q29AK9 (/ISS) |
|
Regulation of defense response to fungus, incompatible interaction GO:2000072
Any process that modulates the frequency, rate or extent of defense response to fungus, incompatible interaction.
|
2 | Q9FMR9 (/IMP) Q9FMR9 (/IMP) |
|
Epithelial cilium movement involved in extracellular fluid movement GO:0003351
The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
|
1 | Q8AWW7 (/IMP) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | Q9VH07 (/IC) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | Q8AWW7 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q9VH07 (/IMP) |
|
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
|
1 | Q9VH07 (/IDA) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
1 | Q9VH07 (/IMP) |
|
Histone exchange GO:0043486
The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.
|
1 | Q9VH07 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q8AWW7 (/NAS) |
|
Regulation of heart growth GO:0060420
Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.
|
1 | Q8AWW7 (/IMP) |
|
Axonemal dynein complex assembly GO:0070286
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
|
1 | Q8AWW7 (/IMP) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
1 | Q9VH07 (/IMP) |
|
Mitotic spindle assembly GO:0090307
The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis.
|
1 | Q9VH07 (/IMP) |
There are 36 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
45 |
P60123 (/IDA)
P60123 (/IDA)
P60123 (/IDA)
P60123 (/IDA)
P60123 (/IDA)
Q9FMR9 (/IDA)
Q9FMR9 (/IDA)
Q9VH07 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(35 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
41 |
Q581V4 (/IDA)
Q581V4 (/IDA)
Q581V4 (/IDA)
Q581V4 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(31 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
40 |
Q8AWW7 (/IDA)
Q9FMR9 (/IDA)
Q9FMR9 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(30 more) |
|
Ino80 complex GO:0031011
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
|
38 |
Q9VH07 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(28 more) |
|
NuA4 histone acetyltransferase complex GO:0035267
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
|
38 |
Q9VH07 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(28 more) |
|
Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
37 |
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
Q9Y265 (/TAS)
(27 more) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
37 |
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
Q9Y265 (/HDA)
(27 more) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
R2TP complex GO:0097255
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
|
37 |
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
Q9Y265 (/IDA)
(27 more) |
|
Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
|
12 |
P60122 (/ISS)
P60122 (/ISS)
P60122 (/ISS)
P60122 (/ISS)
P60122 (/ISS)
P60123 (/ISS)
P60123 (/ISS)
P60123 (/ISS)
P60123 (/ISS)
P60123 (/ISS)
(2 more) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
12 |
P60122 (/ISS)
P60122 (/ISS)
P60122 (/ISS)
P60122 (/ISS)
P60122 (/ISS)
P60123 (/ISS)
P60123 (/ISS)
P60123 (/ISS)
P60123 (/ISS)
P60123 (/ISS)
(2 more) |
|
NuA4 histone acetyltransferase complex GO:0035267
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
|
10 | P60122 (/ISS) P60122 (/ISS) P60122 (/ISS) P60122 (/ISS) P60122 (/ISS) P60123 (/ISS) P60123 (/ISS) P60123 (/ISS) P60123 (/ISS) P60123 (/ISS) |
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Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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6 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) Q4Q2J4 (/ISO) |
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Swr1 complex GO:0000812
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.
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5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
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Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
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Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
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Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
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5 | P60123 (/IDA) P60123 (/IDA) P60123 (/IDA) P60123 (/IDA) P60123 (/IDA) |
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Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
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5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
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Ino80 complex GO:0031011
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
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5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
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Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
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5 | P60123 (/IDA) P60123 (/IDA) P60123 (/IDA) P60123 (/IDA) P60123 (/IDA) |
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Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
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5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
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NuA4 histone acetyltransferase complex GO:0035267
A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
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5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
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MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
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5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
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R2TP complex GO:0097255
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
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5 | P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) P60122 (/ISO) |
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Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
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5 | P60122 (/IDA) P60122 (/IDA) P60122 (/IDA) P60122 (/IDA) P60122 (/IDA) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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4 | Q581V4 (/IDA) Q581V4 (/IDA) Q581V4 (/IDA) Q581V4 (/IDA) |
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Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
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4 | Q581V4 (/IDA) Q581V4 (/IDA) Q581V4 (/IDA) Q581V4 (/IDA) |
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Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
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4 | Q581V4 (/IDA) Q581V4 (/IDA) Q581V4 (/IDA) Q581V4 (/IDA) |
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Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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2 | Q0IFL2 (/ISS) Q29AK9 (/ISS) |
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Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
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2 | Q9FMR9 (/IDA) Q9FMR9 (/IDA) |
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Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
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2 | Q9FMR9 (/IDA) Q9FMR9 (/IDA) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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1 | Q4Q2J4 (/ISO) |
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Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
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1 | Q4Q2J4 (/ISO) |
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Brahma complex GO:0035060
A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof.
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1 | Q9VH07 (/IDA) |
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Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
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1 | Q4Q2J4 (/ISO) |