The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 298: ATP-binding cassette sub-family A member 12

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 B2RY11 (/IPI) B2RY21 (/IPI) E9Q876 (/IPI) Q86UK0 (/IPI)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
4 Q555Z5 (/IGC) Q8T6J1 (/IGC) Q8T6J2 (/IGC) Q8T6J5 (/IGC)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Lipid transporter activity GO:0005319
Enables the directed movement of lipids into, out of or within a cell, or between cells.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Apolipoprotein A-I receptor binding GO:0034191
Interacting selectively and non-covalently with an apolipoprotein A-I receptor.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
2 Q9VRG4 (/ISS) Q9VVJ9 (/ISS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q86UK0 (/IPI)
Lipid transporter activity GO:0005319
Enables the directed movement of lipids into, out of or within a cell, or between cells.
1 Q86UK0 (/IDA)
Lipid transporter activity GO:0005319
Enables the directed movement of lipids into, out of or within a cell, or between cells.
1 Q86UK0 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q385F7 (/ISM)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q86UK0 (/NAS)
ATPase-coupled lipid transmembrane transporter activity GO:0034040
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out).
1 Q86UK0 (/IC)
Apolipoprotein A-I receptor binding GO:0034191
Interacting selectively and non-covalently with an apolipoprotein A-I receptor.
1 Q86UK0 (/IPI)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
1 Q385F7 (/ISM)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sorocarp morphogenesis GO:0031288
The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum.
4 Q54BT5 (/IMP) Q555Z5 (/IMP) Q8T6J1 (/IMP) Q8T6J2 (/IMP)
Lipid transport GO:0006869
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
3 B2RY11 (/IGI) B2RY21 (/IGI) E9Q876 (/IGI)
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
3 B2RY11 (/IMP) B2RY21 (/IMP) E9Q876 (/IMP)
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
3 B2RY11 (/IMP) B2RY21 (/IMP) E9Q876 (/IMP)
Keratinization GO:0031424
The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.
3 B2RY11 (/IMP) B2RY21 (/IMP) E9Q876 (/IMP)
Secretion by cell GO:0032940
The controlled release of a substance by a cell.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Phospholipid efflux GO:0033700
The directed movement of a phospholipid out of a cell or organelle.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Ceramide transport GO:0035627
The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.
3 B2RY11 (/IMP) B2RY21 (/IMP) E9Q876 (/IMP)
Surfactant homeostasis GO:0043129
Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.
3 B2RY11 (/IMP) B2RY21 (/IMP) E9Q876 (/IMP)
Regulated exocytosis GO:0045055
A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Lung alveolus development GO:0048286
The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
3 B2RY11 (/IMP) B2RY21 (/IMP) E9Q876 (/IMP)
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
3 B2RY11 (/IMP) B2RY21 (/IMP) E9Q876 (/IMP)
Establishment of skin barrier GO:0061436
Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.
3 B2RY11 (/IMP) B2RY21 (/IMP) E9Q876 (/IMP)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Positive regulation of protein localization to cell surface GO:2000010
Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
3 B2RY11 (/IMP) B2RY21 (/IMP) E9Q876 (/IMP)
Neutral lipid metabolic process GO:0006638
The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.
1 E9PX95 (/IDA)
Lipid transport GO:0006869
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
1 Q86UK0 (/IDA)
Lipid transport GO:0006869
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
1 Q86UK0 (/NAS)
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
1 Q86UK0 (/IDA)
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
1 Q86UK0 (/NAS)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 Q8T6J2 (/HMP)
Secretion by cell GO:0032940
The controlled release of a substance by a cell.
1 Q86UK0 (/IMP)
Phospholipid efflux GO:0033700
The directed movement of a phospholipid out of a cell or organelle.
1 Q86UK0 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 Q86UQ4 (/TAS)
Regulated exocytosis GO:0045055
A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
1 Q86UK0 (/IMP)
Epidermis morphogenesis GO:0048730
The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
1 F1QLU8 (/IMP)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
1 Q86UK0 (/TAS)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 Q86UK0 (/IDA)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 Q86UK0 (/IMP)
Positive regulation of phospholipid efflux GO:1902995
Any process that activates or increases the frequency, rate or extent of phospholipid efflux.
1 B2RY11 (/IMP)
Positive regulation of reverse cholesterol transport GO:1903064
Any process that activates or increases the frequency, rate or extent of reverse cholesterol transport.
1 B2RY21 (/IMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
3 B2RY11 (/HDA) B2RY21 (/HDA) E9Q876 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 B2RY11 (/IDA) B2RY21 (/IDA) E9Q876 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Epidermal lamellar body GO:0097209
A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.
3 B2RY11 (/ISO) B2RY21 (/ISO) E9Q876 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q385F7 (/IDA) Q86UK0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q86UK0 (/TAS) Q86UQ4 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9VRG4 (/ISS) Q9VVJ9 (/ISS)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
1 Q84M24 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 E9PX95 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q86UK0 (/IDA)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q385F7 (/ISM)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q86UK0 (/NAS)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
1 Q86UQ4 (/TAS)
Azurophil granule membrane GO:0035577
The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
1 Q86UQ4 (/TAS)
Epidermal lamellar body GO:0097209
A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.
1 Q86UK0 (/IDA)