The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 199: Origin recognition complex subunit 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P54784 (/IPI) P54789 (/IPI) Q13415 (/IPI) Q710E8 (/IPI) Q96F82 (/IPI) Q9SU24 (/IPI) Q9SU24 (/IPI)
Double-stranded methylated DNA binding GO:0010385
Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
3 Q710E8 (/IDA) Q9SU24 (/IDA) Q9SU24 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q13415 (/TAS) Q9Z1N2 (/TAS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P54784 (/IDA) Q80Z32 (/IDA)
DNA replication origin binding GO:0003688
Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
2 P54784 (/IDA) P54789 (/IDA)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
2 Q9SU24 (/IDA) Q9SU24 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q9Z1N2 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P54784 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P54784 (/IMP)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P54789 (/ISS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 P54784 (/IMP)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 P54789 (/ISS)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to yeast GO:0001878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.
7 A0A0R4IFH7 (/IDA) A0A2R8QDP7 (/IDA) A0A2R8QHH5 (/IDA) A9JT59 (/IDA) F1QLF9 (/IDA) I3ITQ7 (/IDA) Q7ZYW6 (/IDA)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
7 A0A0R4IFH7 (/IMP) A0A2R8QDP7 (/IMP) A0A2R8QHH5 (/IMP) A9JT59 (/IMP) F1QLF9 (/IMP) I3ITQ7 (/IMP) Q7ZYW6 (/IMP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
7 A0A0R4IFH7 (/IMP) A0A2R8QDP7 (/IMP) A0A2R8QHH5 (/IMP) A9JT59 (/IMP) F1QLF9 (/IMP) I3ITQ7 (/IMP) Q7ZYW6 (/IMP)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
3 Q710E8 (/ISS) Q9SU24 (/ISS) Q9SU24 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 Q710E8 (/IMP) Q9SU24 (/IMP) Q9SU24 (/IMP)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
2 Q13415 (/TAS) Q9Z1N2 (/TAS)
Double fertilization forming a zygote and endosperm GO:0009567
Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana.
2 Q9SU24 (/IMP) Q9SU24 (/IMP)
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
1 Q13415 (/TAS)
Regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
1 Q13415 (/TAS)
Pre-replicative complex assembly involved in nuclear cell cycle DNA replication GO:0006267
The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation.
1 P54784 (/IDA)
Pre-replicative complex assembly involved in nuclear cell cycle DNA replication GO:0006267
The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation.
1 P54784 (/IMP)
DNA replication initiation GO:0006270
The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
1 O16810 (/IDA)
DNA replication initiation GO:0006270
The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
1 P54784 (/IMP)
DNA replication initiation GO:0006270
The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
1 Q13415 (/TAS)
DNA amplification GO:0006277
The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment.
1 O16810 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 O16810 (/IMP)
Response to sucrose GO:0009744
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.
1 Q5SMU7 (/IDA)
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
1 P54784 (/IDA)
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
1 P54784 (/IGI)
Mitotic DNA replication checkpoint GO:0033314
A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
1 P54789 (/IGI)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 Q80Z32 (/IMP)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 Q9Z1N2 (/ISO)
Positive regulation of G0 to G1 transition GO:0070318
A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase.
1 Q80Z32 (/IMP)
Positive regulation of G0 to G1 transition GO:0070318
A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase.
1 Q9Z1N2 (/ISO)
Mitotic DNA replication GO:1902969
Any nuclear DNA replication that is involved in a mitotic cell cycle.
1 P54789 (/IMP)
Mitotic DNA replication initiation GO:1902975
Any DNA replication initiation involved in mitotic cell cycle DNA replication.
1 P54789 (/IC)

There are 26 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P54784 (/IDA) Q13415 (/IDA) Q5SMU7 (/IDA) Q80Z32 (/IDA)
Nuclear origin of replication recognition complex GO:0005664
A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
4 O16810 (/IDA) P54784 (/IDA) P54789 (/IDA) Q13415 (/IDA)
Nuclear origin of replication recognition complex GO:0005664
A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
4 Q58DC8 (/ISS) Q80Z32 (/ISS) Q9JI69 (/ISS) Q9Z1N2 (/ISS)
Origin recognition complex GO:0000808
A multisubunit complex that is located at the replication origins of a chromosome.
3 Q710E8 (/ISS) Q9SU24 (/ISS) Q9SU24 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q13415 (/TAS) Q9Z1N2 (/TAS)
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
1 Q13415 (/HDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 P54789 (/IDA)
Origin recognition complex GO:0000808
A multisubunit complex that is located at the replication origins of a chromosome.
1 Q13415 (/IDA)
Origin recognition complex GO:0000808
A multisubunit complex that is located at the replication origins of a chromosome.
1 Q9Z1N2 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P54789 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9Z1N2 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q13415 (/TAS)
Nuclear pre-replicative complex GO:0005656
A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.
1 P54789 (/IC)
Nuclear pre-replicative complex GO:0005656
A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.
1 P54784 (/IDA)
Nuclear origin of replication recognition complex GO:0005664
A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
1 P54784 (/IMP)
Nuclear origin of replication recognition complex GO:0005664
A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
1 Q9Z1N2 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q13415 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9Z1N2 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q13415 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9Z1N2 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q13415 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q13415 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Z1N2 (/ISO)
DNA replication preinitiation complex GO:0031261
A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
1 P54789 (/IC)
DNA replication preinitiation complex GO:0031261
A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
1 P54784 (/IDA)
Nuclear replication fork GO:0043596
The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
1 P54789 (/IC)