The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1767: Rab family GTPase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
10 P36017 (/IDA) P36017 (/IDA) P36017 (/IDA) P36017 (/IDA) P36017 (/IDA) P36017 (/IDA) P36017 (/IDA) P36017 (/IDA) P36017 (/IDA) P36017 (/IDA)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
10 P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 P36017 (/IPI) P36017 (/IPI) P36017 (/IPI) P36017 (/IPI) P36017 (/IPI) P36017 (/IPI) P36017 (/IPI) P36017 (/IPI) P36017 (/IPI) P36017 (/IPI)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Vacuole inheritance GO:0000011
The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.
10 P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP)
Protein targeting to vacuole GO:0006623
The process of directing proteins towards the vacuole, usually using signals contained within the protein.
10 P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP)
Golgi to endosome transport GO:0006895
The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.
10 P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI)
Golgi to endosome transport GO:0006895
The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.
10 P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
10 P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP)
Late endosome to vacuole transport via multivesicular body sorting pathway GO:0032511
The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole.
10 P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI)
Protein localization to endosome GO:0036010
A process in which a protein is transported to, or maintained in, a location within an endosome.
10 P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI)
Multivesicular body assembly GO:0036258
The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
10 P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI) P36017 (/IGI)
Reticulophagy GO:0061709
The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.
10 P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP)
Endocytosed protein transport to vacuole GO:0007038
The directed movement of proteins imported into a cell by endocytosis to the vacuole.
3 Q59X89 (/IMP) Q59X89 (/IMP) Q59X89 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
3 Q59X89 (/IMP) Q59X89 (/IMP) Q59X89 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
3 Q59X89 (/IMP) Q59X89 (/IMP) Q59X89 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
3 Q59X89 (/IMP) Q59X89 (/IMP) Q59X89 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
10 P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA) P36017 (/HDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
10 P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP) P36017 (/IMP)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
3 Q59X89 (/IDA) Q59X89 (/IDA) Q59X89 (/IDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
3 Q59X89 (/IDA) Q59X89 (/IDA) Q59X89 (/IDA)