The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1152: tRNA-splicing endonuclease, putative

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
5'-3' DNA/RNA helicase activity GO:0033678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 5' to 3'.
3 Q00416 (/IDA) Q00416 (/IDA) Q92355 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 Q00416 (/HDA) Q00416 (/HDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q00416 (/IPI) Q00416 (/IPI)
DNA-dependent ATPase activity GO:0008094
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
2 Q00416 (/ISS) Q00416 (/ISS)
RNA-dependent ATPase activity GO:0008186
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.
2 Q00416 (/ISS) Q00416 (/ISS)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 Q00416 (/IDA) Q00416 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 Q00416 (/IMP) Q00416 (/IMP)
5'-3' RNA helicase activity GO:0032574
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 5' to 3'.
2 Q00416 (/ISS) Q00416 (/ISS)
5'-3' DNA helicase activity GO:0043139
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.
2 Q00416 (/IDA) Q00416 (/IDA)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
1 O94387 (/ISO)
5'-3' RNA helicase activity GO:0032574
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 5' to 3'.
1 Q92355 (/IDA)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription-coupled nucleotide-excision repair GO:0006283
The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.
2 Q00416 (/IGI) Q00416 (/IGI)
DNA-templated transcription, termination GO:0006353
The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.
2 Q00416 (/IMP) Q00416 (/IMP)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
2 Q00416 (/IMP) Q00416 (/IMP)
Termination of RNA polymerase II transcription GO:0006369
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.
2 Q00416 (/IMP) Q00416 (/IMP)
MRNA polyadenylation GO:0006378
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
2 Q00416 (/IMP) Q00416 (/IMP)
TRNA processing GO:0008033
The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
2 Q00416 (/IMP) Q00416 (/IMP)
SnRNA processing GO:0016180
Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule.
2 Q00416 (/IMP) Q00416 (/IMP)
MRNA 3'-end processing GO:0031124
Any process involved in forming the mature 3' end of an mRNA molecule.
2 Q00416 (/IMP) Q00416 (/IMP)
SnoRNA 3'-end processing GO:0031126
Any process involved in forming the mature 3' end of a snoRNA molecule.
2 Q00416 (/IMP) Q00416 (/IMP)
DNA-dependent DNA replication maintenance of fidelity GO:0045005
A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair.
2 Q00416 (/IMP) Q00416 (/IMP)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
2 Q00416 (/IMP) Q00416 (/IMP)
Regulation of transcription from RNA polymerase II promoter in response to DNA damage GO:1990248
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage.
2 Q00416 (/IMP) Q00416 (/IMP)
Termination of RNA polymerase II transcription GO:0006369
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.
1 Q92355 (/ISO)
TRNA metabolic process GO:0006399
The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.
1 O94387 (/NAS)
RNA 3'-end processing GO:0031123
Any process involved in forming the mature 3' end of an RNA molecule.
1 O94387 (/ISO)
Negative regulation of RNA polymerase III activity GO:1903623
Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase III activity.
1 Q92355 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O94387 (/HDA) Q92355 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q00416 (/IDA) Q00416 (/IDA)
Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
2 Q00416 (/IDA) Q00416 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q00416 (/IDA) Q00416 (/IDA)
Nrd1 complex GO:0035649
A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p.
2 Q00416 (/IDA) Q00416 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q92355 (/IDA)
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
1 O94387 (/IDA)