The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 114: ATP-dependent RNA helicase DDX6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
37 O97285 (/IPI) O97285 (/IPI) O97285 (/IPI) O97285 (/IPI) O97285 (/IPI) O97285 (/IPI) O97285 (/IPI) O97285 (/IPI) O97285 (/IPI) O97285 (/IPI)
(27 more)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
16 P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) Q38BK1 (/IDA) Q38BK1 (/IDA) Q38BK1 (/IDA)
(6 more)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
15 P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS)
(5 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
14 P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA)
(4 more)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
14 O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA)
(4 more)
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
14 P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS)
(4 more)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
14 P26196 (/IPI) P26196 (/IPI) P26196 (/IPI) P26196 (/IPI) P26196 (/IPI) P26196 (/IPI) P26196 (/IPI) P26196 (/IPI) P26196 (/IPI) P26196 (/IPI)
(4 more)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
14 P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA)
(4 more)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
8 P39517 (/ISS) P39517 (/ISS) P39517 (/ISS) P39517 (/ISS) P39517 (/ISS) P39517 (/ISS) P39517 (/ISS) Q95YF3 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
7 P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
7 P39517 (/HDA) P39517 (/HDA) P39517 (/HDA) P39517 (/HDA) P39517 (/HDA) P39517 (/HDA) P39517 (/HDA)
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
4 Q38BK1 (/ISM) Q38BK1 (/ISM) Q38BK1 (/ISM) Q38BK1 (/ISM)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
4 Q38BK1 (/ISM) Q38BK1 (/ISM) Q38BK1 (/ISM) Q38BK1 (/ISM)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P23128 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P54823 (/ISO)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Viral RNA genome packaging GO:0019074
The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid.
14 P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP)
(4 more)
Cytoplasmic mRNA processing body assembly GO:0033962
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
14 P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA)
(4 more)
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
14 P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS)
(4 more)
Cytoplasmic mRNA processing body assembly GO:0033962
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
9 P23128 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) Q95YF3 (/IMP)
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
9 E7F1G8 (/IMP) E7FD91 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
8 P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) Q95YF3 (/IMP)
Deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290
Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
7 P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP)
Regulation of cytoplasmic mRNA processing body assembly GO:0010603
Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
7 P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA)
Regulation of cytoplasmic mRNA processing body assembly GO:0010603
Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
7 P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP)
Cytoplasmic mRNA processing body assembly GO:0033962
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
7 P39517 (/IGI) P39517 (/IGI) P39517 (/IGI) P39517 (/IGI) P39517 (/IGI) P39517 (/IGI) P39517 (/IGI)
Negative regulation of translational elongation GO:0045900
Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.
7 P39517 (/IGI) P39517 (/IGI) P39517 (/IGI) P39517 (/IGI) P39517 (/IGI) P39517 (/IGI) P39517 (/IGI)
Negative regulation of translational elongation GO:0045900
Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.
7 P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP) P39517 (/IMP)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
4 Q38BK1 (/ISM) Q38BK1 (/ISM) Q38BK1 (/ISM) Q38BK1 (/ISM)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 E7F1G8 (/IGI) E7FD91 (/IGI)
Viral process GO:0016032
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
2 Q8RXK6 (/IMP) Q8RXK6 (/IMP)
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
2 E7F1G8 (/IGI) E7FD91 (/IGI)
Deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290
Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
1 Q09181 (/ISO)
Gamete generation GO:0007276
The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
1 Q95YF3 (/IMP)
Pole cell formation GO:0007279
Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells.
1 P23128 (/IGI)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 D3ZD73 (/IEP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q95YF3 (/IMP)
MRNA metabolic process GO:0016071
The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
1 Q95YF3 (/IMP)
MRNA metabolic process GO:0016071
The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
1 Q95YF3 (/TAS)
Viral RNA genome packaging GO:0019074
The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid.
1 P54823 (/ISO)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
1 P54823 (/IMP)
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
1 P23128 (/IMP)
Cytoplasmic mRNA processing body assembly GO:0033962
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
1 P54823 (/ISO)
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
1 P23128 (/IGI)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q95YF3 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 P54823 (/IMP)
Habituation GO:0046959
A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented.
1 P23128 (/IMP)
Spermatid differentiation GO:0048515
The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
1 D3ZD73 (/IEP)
Regulation of defense response to virus GO:0050688
Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.
1 P23128 (/IMP)
Positive regulation of posttranscriptional gene silencing GO:0060148
Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism.
1 P23128 (/IMP)
Regulation of olfactory learning GO:0090328
Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
1 P23128 (/IMP)
Regulation of neuron projection arborization GO:0150011
Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.
1 P23128 (/IMP)
Positive regulation of miRNA mediated inhibition of translation GO:1905618
Any process that activates or increases the frequency, rate or extent of miRNA mediated inhibition of translation.
1 P23128 (/IDA)
Positive regulation of miRNA mediated inhibition of translation GO:1905618
Any process that activates or increases the frequency, rate or extent of miRNA mediated inhibition of translation.
1 P23128 (/IMP)
Messenger ribonucleoprotein complex assembly GO:1990120
The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex.
1 P23128 (/IMP)
Negative regulation of cytoplasmic translation GO:2000766
Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation.
1 P23128 (/IMP)

There are 48 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
37 O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA) O97285 (/IDA)
(27 more)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
29 P23128 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA)
(19 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
24 P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA)
(14 more)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
17 E7F1G8 (/IDA) E7FD91 (/IDA) P23128 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA)
(7 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
16 P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA)
(6 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
15 P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA)
(5 more)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
14 P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP) P26196 (/IMP)
(4 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS) P26196 (/TAS)
(4 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
14 P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA) P26196 (/HDA)
(4 more)
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
14 P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA) P26196 (/IDA)
(4 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P23128 (/HDA) P39517 (/HDA) P39517 (/HDA) P39517 (/HDA) P39517 (/HDA) P39517 (/HDA) P39517 (/HDA) P39517 (/HDA) Q09181 (/HDA)
Cytoplasmic side of membrane GO:0098562
The side of a membrane that faces the cytoplasm.
7 P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA) P39517 (/IDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
2 P54823 (/ISS) Q5RFQ5 (/ISS)
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
2 P23128 (/IDA) Q95YF3 (/IDA)
Messenger ribonucleoprotein complex GO:1990124
A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.
2 P23128 (/IDA) Q95YF3 (/IDA)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
2 P54824 (/IPI) P54824 (/IPI)
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
1 D3ZD73 (/IDA)
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
1 P54823 (/ISO)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
1 P54823 (/ISO)
Outer dense fiber GO:0001520
A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins.
1 D3ZD73 (/IDA)
Outer dense fiber GO:0001520
A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins.
1 P54823 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P54823 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 D3ZD73 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P54823 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P54823 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q5RFQ5 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 D3ZD73 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P54823 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P54823 (/ISO)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 D3ZD73 (/IDA)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 P54823 (/ISO)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
1 P54823 (/ISO)
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
1 P54823 (/ISO)
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
1 D3ZD73 (/IDA)
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
1 P54823 (/ISO)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
1 P54823 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P23128 (/IDA)
Intracellular organelle GO:0043229
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
1 Q95YF3 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 D3ZD73 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P54823 (/ISO)
Concave side of sperm head GO:0061830
The concave part of the late spermatid head or spermatozoon head that forms the ventral portion of the head, particularly in some rodent species.
1 D3ZD73 (/IDA)
Concave side of sperm head GO:0061830
The concave part of the late spermatid head or spermatozoon head that forms the ventral portion of the head, particularly in some rodent species.
1 P54823 (/ISO)
Neuronal ribonucleoprotein granule GO:0071598
A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.
1 P23128 (/IDA)
Sensory dendrite GO:0071683
A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron.
1 P23128 (/IDA)
Sperm annulus GO:0097227
The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity.
1 D3ZD73 (/IDA)
Sperm annulus GO:0097227
The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity.
1 P54823 (/ISO)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 P23128 (/IDA)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
1 Q95YF3 (/IDA)