View in Gene3D

CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1133: UMP-CMP kinase 2, mitochondrial

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UMP/CMP kinase. [EC: 2.7.4.14]
(1) ATP + (d)CMP = ADP + (d)CDP. (2) ATP + UMP = ADP + UDP.
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase.
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22.
  • Formerly EC 2.7.4.5.
 2 Q3U5Q7 Q5EBM0
Nucleoside-diphosphate kinase. [EC: 2.7.4.6]
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
  • Many nucleoside diphosphates can act as acceptors.
  • Many ribo- and deoxyribonucleoside triphosphates can act as donors.
 2 Q3U5Q7 Q5EBM0