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CATH Superfamily 3.40.50.200

Peptidase S8/S53 domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptidase S8/S53 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Subtilisin-like serine protease

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Oryzin. [EC: 3.4.21.63]
Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt > Ac-Tyr-OEt. Does not hydrolyze peptide amides.
  • Predominant extracellular alkaline endopeptidase of the mold Aspergillus oryzae.
  • Identical or closely related enzymes are produced by A.flavus and A.sojae.
  • Belongs to peptidase family S8.
  • Formerly EC 3.4.4.16, EC 3.4.21.14 and EC 3.4.21.15.
 16 A0A0J5PVB2 A0A0J5PVB2 A0A0J5PVB2 A0A0J5PVB2 A0A229XVZ3 A0A229XVZ3 A0A229XVZ3 A0A229XVZ3 B0Y473 B0Y473
(6 more...)
Subtilisin. [EC: 3.4.21.62]
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
  • Subtilisin is a serine endopeptidase that evolved independently of chymotrypsin.
  • It contains no cysteine residues (although these are found in homologous enzymes).
  • Species variants include subtilisin BPN' (also subtilisin B, subtilopeptidase C, nagarse, nagarse proteinase, subtilisin Novo, bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A, subtilopeptidase A, alcalase Novo).
  • Similar enzymes are produced by various Bacillus subtilis strains and other Bacillus species.
  • Belongs to peptidase family S8.
  • Formerly EC 3.4.4.16 and EC 3.4.21.14.
 4 A0A1D8NQQ9 A0A1D8NQQ9 P09230 P09230
Cerevisin. [EC: 3.4.21.48]
Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt > Ac-Tyr-OEt. Does not hydrolyze peptide amides.
  • Contains a Cys residue near the active site His, and is inhibited by mercurials.
  • Proteinase ycaB is a similar enzyme from the yeast Candida albicans.
  • Belongs to peptidase family S8.
  • Formerly EC 3.4.22.9.
 1 P09232