The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 24: acyl-coenzyme A thioesterase 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acyl-CoA hydrolase activity GO:0047617
Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
12 O55137 (/IDA) O55171 (/IDA) O88267 (/IDA) P49753 (/IDA) Q6Q2Z6 (/IDA) Q86TX2 (/IDA) Q86TX2 (/IDA) Q8BWN8 (/IDA) Q8BWN8 (/IDA) Q8N9L9 (/IDA)
(2 more)
Acyl-CoA hydrolase activity GO:0047617
Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
6 O55137 (/ISO) Q8BWN8 (/ISO) Q8BWN8 (/ISO) Q9QYR7 (/ISO) Q9QYR7 (/ISO) Q9QYR9 (/ISO)
Acyl-CoA hydrolase activity GO:0047617
Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
6 O55137 (/TAS) Q8BWN8 (/TAS) Q8BWN8 (/TAS) Q9QYR7 (/TAS) Q9QYR7 (/TAS) Q9QYR9 (/TAS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
4 Q8BWN8 (/ISO) Q8BWN8 (/ISO) Q91X34 (/ISO) Q9QYR9 (/ISO)
N-acyltransferase activity GO:0016410
Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.
3 A2AKK5 (/IDA) Q14032 (/IDA) Q91X34 (/IDA)
Succinyl-CoA hydrolase activity GO:0004778
Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate.
2 Q8BWN8 (/ISO) Q8BWN8 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P49753 (/IPI) Q14032 (/IPI)
N-acyltransferase activity GO:0016410
Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.
2 Q5FVR5 (/ISS) Q8BGG9 (/ISS)
Succinyl-CoA hydrolase activity GO:0004778
Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate.
1 Q8N9L9 (/IDA)
Palmitoyl-CoA hydrolase activity GO:0016290
Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.
1 O55171 (/IDA)
Palmitoyl-CoA hydrolase activity GO:0016290
Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.
1 Q9QYR9 (/ISO)
N-acyltransferase activity GO:0016410
Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.
1 Q91X34 (/ISO)
Transferase activity, transferring acyl groups GO:0016746
Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
1 Q14032 (/TAS)
Glycine N-choloyltransferase activity GO:0047963
Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate.
1 Q14032 (/IDA)
Glycine N-choloyltransferase activity GO:0047963
Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate.
1 Q91X34 (/ISO)
Medium-chain acyl-CoA hydrolase activity GO:0052815
Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length.
1 Q14032 (/IDA)
Medium-chain acyl-CoA hydrolase activity GO:0052815
Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length.
1 Q91X34 (/ISO)
Long-chain acyl-CoA hydrolase activity GO:0052816
Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length.
1 Q14032 (/IDA)
Long-chain acyl-CoA hydrolase activity GO:0052816
Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length.
1 Q91X34 (/ISO)
Very long chain acyl-CoA hydrolase activity GO:0052817
Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18.
1 Q14032 (/IDA)
Very long chain acyl-CoA hydrolase activity GO:0052817
Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18.
1 Q91X34 (/ISO)

There are 45 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
11 O55171 (/IDA) P49753 (/IDA) Q14032 (/IDA) Q6Q2Z6 (/IDA) Q86TX2 (/IDA) Q86TX2 (/IDA) Q8BWN8 (/IDA) Q8BWN8 (/IDA) Q8N9L9 (/IDA) Q9QYR7 (/IDA)
(1 more)
Long-chain fatty acid metabolic process GO:0001676
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
9 O55137 (/IDA) O88267 (/IDA) P49753 (/IDA) Q6Q2Z6 (/IDA) Q86TX2 (/IDA) Q86TX2 (/IDA) Q8N9L9 (/IDA) Q9QYR7 (/IDA) Q9QYR7 (/IDA)
Very long-chain fatty acid metabolic process GO:0000038
The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.
7 P49753 (/IDA) Q6Q2Z6 (/IDA) Q86TX2 (/IDA) Q86TX2 (/IDA) Q8N9L9 (/IDA) Q9QYR7 (/IDA) Q9QYR7 (/IDA)
Long-chain fatty acid metabolic process GO:0001676
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
6 O55137 (/ISO) Q8BWN8 (/ISO) Q8BWN8 (/ISO) Q9QYR7 (/ISO) Q9QYR7 (/ISO) Q9QYR9 (/ISO)
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
6 Q8BWN8 (/ISO) Q8BWN8 (/ISO) Q91X34 (/ISO) Q9QYR7 (/ISO) Q9QYR7 (/ISO) Q9QYR9 (/ISO)
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
6 O55137 (/TAS) P49753 (/TAS) Q86TX2 (/TAS) Q86TX2 (/TAS) Q8N9L9 (/TAS) Q9QYR9 (/TAS)
Very long-chain fatty acid metabolic process GO:0000038
The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.
5 Q8BWN8 (/ISO) Q8BWN8 (/ISO) Q9QYR7 (/ISO) Q9QYR7 (/ISO) Q9QYR9 (/ISO)
Saturated monocarboxylic acid metabolic process GO:0032788
The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds.
4 Q6Q2Z6 (/IDA) Q8N9L9 (/IDA) Q9QYR7 (/IDA) Q9QYR7 (/IDA)
Unsaturated monocarboxylic acid metabolic process GO:0032789
The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds.
4 Q6Q2Z6 (/IDA) Q8N9L9 (/IDA) Q9QYR7 (/IDA) Q9QYR7 (/IDA)
Succinyl-CoA metabolic process GO:0006104
The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.
3 Q8BWN8 (/IDA) Q8BWN8 (/IDA) Q8N9L9 (/IDA)
Protein targeting to peroxisome GO:0006625
The process of directing proteins towards the peroxisome, usually using signals contained within the protein.
3 P49753 (/TAS) Q14032 (/TAS) Q8N9L9 (/TAS)
Dicarboxylic acid metabolic process GO:0043648
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
3 Q8BWN8 (/IDA) Q8BWN8 (/IDA) Q8N9L9 (/IDA)
Short-chain fatty acid metabolic process GO:0046459
The chemical reactions and pathways involving fatty acids with a chain length of less than C6.
3 Q8BWN8 (/IDA) Q8BWN8 (/IDA) Q8N9L9 (/IDA)
Succinyl-CoA metabolic process GO:0006104
The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.
2 Q8BWN8 (/ISO) Q8BWN8 (/ISO)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
2 Q5FVR5 (/ISS) Q8BGG9 (/ISS)
Saturated monocarboxylic acid metabolic process GO:0032788
The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds.
2 Q8BWN8 (/ISO) Q8BWN8 (/ISO)
Unsaturated monocarboxylic acid metabolic process GO:0032789
The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds.
2 Q8BWN8 (/ISO) Q8BWN8 (/ISO)
Dicarboxylic acid metabolic process GO:0043648
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
2 Q8BWN8 (/ISO) Q8BWN8 (/ISO)
Dicarboxylic acid catabolic process GO:0043649
The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.
2 Q8BWN8 (/ISO) Q8BWN8 (/ISO)
Short-chain fatty acid metabolic process GO:0046459
The chemical reactions and pathways involving fatty acids with a chain length of less than C6.
2 Q8BWN8 (/ISO) Q8BWN8 (/ISO)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 O55171 (/IDA)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q9QYR9 (/ISO)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 Q63276 (/IEP)
Bile acid conjugation GO:0002152
The process in which bile acids are covalently linked to taurine or glycine.
1 Q14032 (/IDA)
Bile acid conjugation GO:0002152
The process in which bile acids are covalently linked to taurine or glycine.
1 Q91X34 (/ISO)
Glycine metabolic process GO:0006544
The chemical reactions and pathways involving glycine, aminoethanoic acid.
1 Q14032 (/IDA)
Glycine metabolic process GO:0006544
The chemical reactions and pathways involving glycine, aminoethanoic acid.
1 Q91X34 (/ISO)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 A2AKK5 (/IDA)
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
1 Q14032 (/IDA)
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
1 Q91X34 (/ISO)
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
1 Q14032 (/TAS)
Bile acid metabolic process GO:0008206
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
1 Q91X34 (/IDA)
Bile acid metabolic process GO:0008206
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
1 Q14032 (/TAS)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 O55171 (/IEP)
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
1 O88267 (/IMP)
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
1 O55137 (/ISO)
Taurine metabolic process GO:0019530
The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.
1 Q14032 (/IDA)
Taurine metabolic process GO:0019530
The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.
1 Q91X34 (/ISO)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 Q63276 (/IEP)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 O55171 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 O55171 (/IEP)
Very long-chain fatty acid catabolic process GO:0042760
The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22.
1 O55171 (/IDA)
Very long-chain fatty acid catabolic process GO:0042760
The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22.
1 Q9QYR9 (/ISO)
Dicarboxylic acid catabolic process GO:0043649
The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.
1 Q8N9L9 (/IDA)
Response to epidermal growth factor GO:0070849
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 O55171 (/IEP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
9 A2AKK5 (/IDA) Q14032 (/IDA) Q63276 (/IDA) Q6Q2Z6 (/IDA) Q8BWN8 (/IDA) Q8BWN8 (/IDA) Q8N9L9 (/IDA) Q9QYR7 (/IDA) Q9QYR7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 O88267 (/IDA) Q14032 (/IDA) Q6Q2Z6 (/IDA) Q86TX2 (/IDA) Q86TX2 (/IDA) Q91X34 (/IDA) Q9QYR7 (/IDA) Q9QYR7 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
7 Q32Q92 (/TAS) Q32Q92 (/TAS) Q6Q2Z6 (/TAS) Q8BWN8 (/TAS) Q8BWN8 (/TAS) Q9QYR7 (/TAS) Q9QYR7 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P49753 (/TAS) Q14032 (/TAS) Q86TX2 (/TAS) Q86TX2 (/TAS) Q8N9L9 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 O55137 (/ISO) Q91X34 (/ISO) Q9QYR7 (/ISO) Q9QYR7 (/ISO)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
3 Q8BWN8 (/ISO) Q8BWN8 (/ISO) Q91X34 (/ISO)
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
3 P49753 (/TAS) Q14032 (/TAS) Q8N9L9 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O55137 (/HDA) Q9QYR9 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O55171 (/IDA) P49753 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 Q5FVR5 (/ISS) Q8BGG9 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O55137 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9QYR9 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9QYR9 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P49753 (/TAS)