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CATH Superfamily 3.40.50.1820

Alpha/Beta hydrolase fold, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 110: Hormone-sensitive lipase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hormone-sensitive lipase. [EC: 3.1.1.79]
(1) Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate. (2) Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. (3) Monoacylglycerol + H(2)O = glycerol + a carboxylate.
  • This enzyme is a serine hydrolase.
  • Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity.
  • It hydrolyzes all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) as well as cholesteryl esters, steroid fatty acid esters, retinyl esters and p-nitrophenyl esters.
  • It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond.
  • The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length.
  • The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP.
 6 P15304 P16386 P54310 Q05469 Q68J42 Q9R101