The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 71: Protein arginine N-methyltransferase 7

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-arginine omega-N symmetric methyltransferase activity GO:0035243
Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.
25 A2AV36 (/ISS) A6QQV6 (/ISS) B0X4N1 (/ISS) B3MF31 (/ISS) B3NP10 (/ISS) B4GA28 (/ISS) B4I8G2 (/ISS) B4JWL5 (/ISS) B4KSL6 (/ISS) B4KSL6 (/ISS)
(15 more)
Histone methyltransferase activity (H4-R3 specific) GO:0044020
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4.
9 A2AV36 (/ISS) A6QQV6 (/ISS) Q5U4E8 (/ISS) Q5ZIB9 (/ISS) Q6PCI6 (/ISS) Q6PCI6 (/ISS) Q99MI9 (/ISS) Q9NVM4 (/ISS) Q9NVM4 (/ISS)
S-adenosylmethionine-dependent methyltransferase activity GO:0008757
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
3 A2AV36 (/ISS) Q5ZIB9 (/ISS) Q922X9 (/ISS)
Protein-arginine omega-N symmetric methyltransferase activity GO:0035243
Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.
3 Q922X9 (/IDA) Q9NVM4 (/IDA) Q9NVM4 (/IDA)
Protein-arginine omega-N symmetric methyltransferase activity GO:0035243
Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.
3 Q9NVM4 (/IMP) Q9NVM4 (/IMP) Q9W1V1 (/IMP)
Histone-arginine N-methyltransferase activity GO:0008469
Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.
2 Q9NVM4 (/IDA) Q9NVM4 (/IDA)
Histone-arginine N-methyltransferase activity GO:0008469
Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.
2 Q5ZIB9 (/ISS) Q922X9 (/ISS)
S-adenosylmethionine-dependent methyltransferase activity GO:0008757
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
2 Q9NVM4 (/IDA) Q9NVM4 (/IDA)
[myelin basic protein]-arginine N-methyltransferase activity GO:0016277
Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine.
2 Q9NVM4 (/IDA) Q9NVM4 (/IDA)
[myelin basic protein]-arginine N-methyltransferase activity GO:0016277
Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine.
2 Q5ZIB9 (/ISS) Q922X9 (/ISS)
Protein-arginine omega-N monomethyltransferase activity GO:0035241
Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine +
2 Q9NVM4 (/IDA) Q9NVM4 (/IDA)
Protein-arginine omega-N monomethyltransferase activity GO:0035241
Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine +
2 Q5ZIB9 (/ISS) Q922X9 (/ISS)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
2 Q9NVM4 (/IC) Q9NVM4 (/IC)
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
2 Q9NVM4 (/IPI) Q9NVM4 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q922X9 (/IPI)
Histone-arginine N-methyltransferase activity GO:0008469
Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.
1 Q922X9 (/ISO)
S-adenosylmethionine-dependent methyltransferase activity GO:0008757
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
1 Q922X9 (/ISO)
Protein-arginine N-methyltransferase activity GO:0016274
Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.
1 Q9W1V1 (/ISS)
[myelin basic protein]-arginine N-methyltransferase activity GO:0016277
Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine.
1 Q922X9 (/ISO)
Protein-arginine omega-N monomethyltransferase activity GO:0035241
Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine +
1 Q922X9 (/ISO)
Protein-arginine omega-N symmetric methyltransferase activity GO:0035243
Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.
1 Q922X9 (/ISO)
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
1 Q922X9 (/ISO)
Histone methyltransferase activity (H4-R3 specific) GO:0044020
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4.
1 Q922X9 (/IDA)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptidyl-arginine methylation GO:0018216
The addition of a methyl group to an arginine residue in a protein.
25 A2AV36 (/ISS) A6QQV6 (/ISS) B0X4N1 (/ISS) B3MF31 (/ISS) B3NP10 (/ISS) B4GA28 (/ISS) B4I8G2 (/ISS) B4JWL5 (/ISS) B4KSL6 (/ISS) B4KSL6 (/ISS)
(15 more)
Regulation of gene expression by genetic imprinting GO:0006349
Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself.
9 A2AV36 (/ISS) A6QQV6 (/ISS) Q5U4E8 (/ISS) Q5ZIB9 (/ISS) Q6PCI6 (/ISS) Q6PCI6 (/ISS) Q99MI9 (/ISS) Q9NVM4 (/ISS) Q9NVM4 (/ISS)
Histone arginine methylation GO:0034969
The modification of a histone by addition of a methyl group to an arginine residue.
9 A2AV36 (/ISS) A6QQV6 (/ISS) Q5U4E8 (/ISS) Q5ZIB9 (/ISS) Q6PCI6 (/ISS) Q6PCI6 (/ISS) Q99MI9 (/ISS) Q9NVM4 (/ISS) Q9NVM4 (/ISS)
DNA methylation involved in gamete generation GO:0043046
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
9 A2AV36 (/ISS) A6QQV6 (/ISS) Q5U4E8 (/ISS) Q5ZIB9 (/ISS) Q6PCI6 (/ISS) Q6PCI6 (/ISS) Q99MI9 (/ISS) Q9NVM4 (/ISS) Q9NVM4 (/ISS)
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
8 A2AV36 (/ISS) A6QQV6 (/ISS) Q5U4E8 (/ISS) Q5ZIB9 (/ISS) Q6PCI6 (/ISS) Q6PCI6 (/ISS) Q922X9 (/ISS) Q99MI9 (/ISS)
Peptidyl-arginine methylation GO:0018216
The addition of a methyl group to an arginine residue in a protein.
3 Q9NVM4 (/IMP) Q9NVM4 (/IMP) Q9W1V1 (/IMP)
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
2 Q9NVM4 (/IMP) Q9NVM4 (/IMP)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
2 Q9NVM4 (/IDA) Q9NVM4 (/IDA)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
2 Q5ZIB9 (/ISS) Q922X9 (/ISS)
Peptidyl-arginine methylation GO:0018216
The addition of a methyl group to an arginine residue in a protein.
2 Q9NVM4 (/IDA) Q9NVM4 (/IDA)
Regulation of protein binding GO:0043393
Any process that modulates the frequency, rate or extent of protein binding.
2 Q9NVM4 (/IC) Q9NVM4 (/IC)
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
1 Q922X9 (/ISO)
Regulation of gene expression by genetic imprinting GO:0006349
Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself.
1 Q922X9 (/IDA)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
1 Q922X9 (/ISO)
Peptidyl-arginine methylation GO:0018216
The addition of a methyl group to an arginine residue in a protein.
1 Q922X9 (/ISO)
Peptidyl-arginine methylation, to asymmetrical-dimethyl arginine GO:0019919
The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine.
1 Q9W1V1 (/ISS)
Histone arginine methylation GO:0034969
The modification of a histone by addition of a methyl group to an arginine residue.
1 Q922X9 (/IDA)
DNA methylation involved in gamete generation GO:0043046
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
1 Q922X9 (/IDA)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 A2AV36 (/ISS) A6QQV6 (/ISS) Q5U4E8 (/ISS) Q5ZIB9 (/ISS) Q6PCI6 (/ISS) Q6PCI6 (/ISS) Q922X9 (/ISS) Q99MI9 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 A2AV36 (/ISS) A6QQV6 (/ISS) Q5U4E8 (/ISS) Q5ZIB9 (/ISS) Q6PCI6 (/ISS) Q6PCI6 (/ISS) Q922X9 (/ISS) Q99MI9 (/ISS)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
4 A0A024R726 (/IDA) A0A024R726 (/IDA) Q9NVM4 (/IDA) Q9NVM4 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 A0A024R726 (/IDA) A0A024R726 (/IDA) Q9NVM4 (/IDA) Q9NVM4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9NVM4 (/IDA) Q9NVM4 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q9NVM4 (/TAS) Q9NVM4 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9NVM4 (/IDA) Q9NVM4 (/IDA)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
1 Q922X9 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q922X9 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q922X9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q922X9 (/ISO)