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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 168: Methyltransferase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
24-methylenesterol C-methyltransferase. [EC: 2.1.1.143]
S-adenosyl-L-methionine + 24-methylenelophenol = S-adenosyl-L- homocysteine + (Z)-24-ethylidenelophenol.
  • This is the second methylation step of plant sterol biosynthesis (cf. EC 2.1.1.142).
 8 A0A178WGT2 A0A178WGT2 A0A178WHI4 A0A178WHI4 Q39227 Q39227 Q94JS4 Q94JS4
Sterol 24-C-methyltransferase. [EC: 2.1.1.41]
S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
  • Acts on a range of sterols with a 24(25)-double bond in the side chain.
  • While zymosterol is the preferred substrate it also acts on desmosterol, 5-alpha-cholesta-7,24-dien-3-beta-ol, 5-alpha-cholesta- 5,7,24-trien-3-beta-ol, 4-alpha-methylzymosterol and others.
  • S-adenosyl-L-methionine attacks the Si face of the 24(25) double bond and the C-24 hydrogen is transferred to C-25 on the Re face of the double bond.
 1 Q54I98