View in Gene3D

CATH Superfamily 3.40.50.11480

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: tubulin--tyrosine ligase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Tubulin--tyrosine ligase. [EC: 6.3.2.25]
ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
  • L-tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyr(omega)-alpha-tubulin).
  • The enzyme is highly specific for alpha-tubulin and moderately specific for ATP and L-tyrosine.
  • L-phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values.
 23 A0A2R9AHG6 A0A2R9AHG6 A0A2R9AHG6 A0A2R9AHG6 A0A481CF77 A0A481CF77 H2P5F4 H2P5F4 H2P5F4 H2P5F4
(13 more...)