View in Gene3D

CATH Superfamily 3.40.50.1110

SGNH hydrolase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SGNH hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: Multifunctional acyl-CoA thioesterase I

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Arylesterase. [EC: 3.1.1.2]
A phenyl acetate + H(2)O = a phenol + acetate.
  • Acts on many phenolic esters.
  • It is likely that the three forms of human paraoxonase are lactonases rather than aromatic esterases.
  • The natural substrates of the paraoxonases are lactones, with (+-)-5- hydroxy-6E,8Z,11Z,4Z-eicostetraenoic-acid 1,5-lactone being the best substrate.
 1190 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5
(1180 more...)
Palmitoyl-CoA hydrolase. [EC: 3.1.2.2]
Palmitoyl-CoA + H(2)O = CoA + palmitate.
  • Also hydrolyzes CoA thioesters of other long-chain fatty acids.
 1190 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5
(1180 more...)
Oleoyl-[acyl-carrier-protein] hydrolase. [EC: 3.1.2.14]
Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate.
  • Acts on [acyl-carrier-protein] thioesters of fatty acids from C(12) to C(18), but the derivative of oleic acid is hydrolyzed much more rapidly than any other compound tested.
 1190 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5
(1180 more...)
Lysophospholipase. [EC: 3.1.1.5]
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
    		 1190 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5 A0A023YSK5
    (1180 more...)
    Carboxylesterase. [EC: 3.1.1.1]
    A carboxylic ester + H(2)O = an alcohol + a carboxylate.
    • Wide specificity; also hydrolyzes vitamin A esters.
    • The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4 and EC 3.5.1.13.
    • Formerly EC 3.1.1.12.
    		 25 A0A0D6H809 A0A0D6H809 A0A0D6H809 A0A0D6H809 A0A0D6H809 A0A2V2TSW9 A0A2V2TSW9 A0A2V2TSW9 A0A2V2TSW9 A0A2V2TSW9
    (15 more...)