The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Toll/interleukin-1 receptor homology (TIR) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Toll-like receptor 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 43 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 E9PTD9 (/IPI) O60603 (/IPI) O60603 (/IPI) Q15399 (/IPI) Q6R5N8 (/IPI) Q6R5P0 (/IPI) Q6YGU2 (/IPI) Q9BXR5 (/IPI) Q9BXR5 (/IPI) Q9JLF7 (/IPI)
(2 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
9 A0A286Y971 (/IDA) A0A2R3VHK9 (/IDA) A0A2R3VHL5 (/IDA) B3DIN1 (/IDA) F8W3J5 (/IDA) F8W4F1 (/IDA) O60603 (/IDA) O60603 (/IDA) Q15399 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
7 O60603 (/IPI) O60603 (/IPI) Q15399 (/IPI) Q6R5N8 (/IPI) Q9BXR5 (/IPI) Q9BXR5 (/IPI) Q9Y2C9 (/IPI)
Toll-like receptor binding GO:0035325
Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
6 A0A286Y971 (/IDA) A0A2R3VHK9 (/IDA) A0A2R3VHL5 (/IDA) B3DIN1 (/IDA) F8W3J5 (/IDA) F8W4F1 (/IDA)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
6 E9PTD9 (/TAS) O60603 (/TAS) O60603 (/TAS) Q15399 (/TAS) Q6YGU2 (/TAS) Q9Y2C9 (/TAS)
Lipopeptide binding GO:0071723
Interacting selectively and non-covalently with a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids.
6 A0A096MKA9 (/IMP) E9PTD9 (/IMP) G3V695 (/IMP) Q6P690 (/IMP) Q6YGU2 (/IMP) Q9EPW9 (/IMP)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
5 A0A096MKA9 (/TAS) G3V695 (/TAS) Q6P690 (/TAS) Q9BXR5 (/TAS) Q9BXR5 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
4 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Lipopeptide binding GO:0071723
Interacting selectively and non-covalently with a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids.
4 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
3 O60603 (/IDA) O60603 (/IDA) Q9QUN7 (/IDA)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
3 Q15399 (/NAS) Q9EPQ1 (/NAS) Q9EPQ1 (/NAS)
Toll-like receptor 2 binding GO:0035663
Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.
3 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9EPW9 (/ISO)
Triacyl lipopeptide binding GO:0042497
Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups.
3 O60603 (/IDA) O60603 (/IDA) Q9QUN7 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 Q0ZUL9 (/ISS) Q704V6 (/ISS) Q9EPW9 (/ISS)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
3 O60603 (/IPI) O60603 (/IPI) Q9QUN7 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 Q9EPW9 (/IPI) Q9QUN7 (/IPI) Q9Y2C9 (/IPI)
Lipopolysaccharide binding GO:0001530
Interacting selectively and non-covalently with lipopolysaccharide.
2 O60603 (/IDA) O60603 (/IDA)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
2 O60603 (/ISS) O60603 (/ISS)
Lipopolysaccharide receptor activity GO:0001875
Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2 O60603 (/TAS) O60603 (/TAS)
Signaling pattern recognition receptor activity GO:0008329
Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity.
2 O60603 (/IDA) O60603 (/IDA)
Toll-like receptor binding GO:0035325
Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
2 O60603 (/IPI) O60603 (/IPI)
Toll-like receptor 2 binding GO:0035663
Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.
2 Q15399 (/IPI) Q9Y2C9 (/IPI)
Triacyl lipopeptide binding GO:0042497
Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups.
2 Q9EPQ1 (/NAS) Q9EPQ1 (/NAS)
Diacyl lipopeptide binding GO:0042498
Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of two acyl groups.
2 Q9EPW9 (/IDA) Q9QUN7 (/IDA)
Peptidoglycan binding GO:0042834
Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
2 O60603 (/IDA) O60603 (/IDA)
Lipopolysaccharide binding GO:0001530
Interacting selectively and non-covalently with lipopolysaccharide.
1 Q9QUN7 (/ISO)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
1 Q9Y2C9 (/IC)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
1 Q9QUN7 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9Y2C9 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9EPW9 (/ISO)
Interleukin-1 receptor binding GO:0005149
Interacting selectively and non-covalently with the interleukin-1 receptor.
1 O60602 (/IPI)
Interleukin-1 receptor binding GO:0005149
Interacting selectively and non-covalently with the interleukin-1 receptor.
1 Q9JLF7 (/ISO)
Signaling pattern recognition receptor activity GO:0008329
Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity.
1 Q9QUN7 (/ISO)
RRNA binding GO:0019843
Interacting selectively and non-covalently with ribosomal RNA.
1 Q6R5N8 (/IDA)
Toll-like receptor binding GO:0035325
Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
1 Q9QUN7 (/ISO)
Triacyl lipopeptide binding GO:0042497
Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups.
1 Q9QUN7 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9Y2C9 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q6R5N8 (/IDA)
Peptidoglycan binding GO:0042834
Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
1 Q9QUN7 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q9QUN7 (/ISO)
Lipoteichoic acid binding GO:0070891
Interacting selectively and non-covalently with lipoteichoic acid.
1 Q9QUN7 (/IDA)
Lipopeptide binding GO:0071723
Interacting selectively and non-covalently with a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids.
1 Q9Y2C9 (/ISS)

There are 207 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to diacyl bacterial lipopeptide GO:0071726
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus.
25 B2LT61 (/ISS) B2LT62 (/ISS) B2LT64 (/ISS) B2LT65 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y614 (/ISS) B3Y615 (/ISS)
(15 more)
Cellular response to triacyl bacterial lipopeptide GO:0071727
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus.
24 B2LT61 (/ISS) B2LT62 (/ISS) B2LT64 (/ISS) B2LT65 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y614 (/ISS) B3Y615 (/ISS)
(14 more)
Activation of immune response GO:0002253
Any process that initiates an immune response.
10 A0A286Y971 (/IMP) A0A2R3VHK9 (/IMP) A0A2R3VHL5 (/IMP) A0A2R8Q551 (/IMP) B3DIN1 (/IMP) F1QWS9 (/IMP) F1R1U3 (/IMP) F8W3J5 (/IMP) F8W4F1 (/IMP) Q6TS42 (/IMP)
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
9 A0A096MKA9 (/IDA) A0A2R8QF98 (/IDA) B3DIC1 (/IDA) E9PTD9 (/IDA) F1QMN8 (/IDA) G3V695 (/IDA) Q6P690 (/IDA) Q6TQG8 (/IDA) Q6YGU2 (/IDA)
MyD88-dependent toll-like receptor signaling pathway GO:0002755
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
9 O60602 (/TAS) O60603 (/TAS) O60603 (/TAS) Q15399 (/TAS) Q2XQ10 (/TAS) Q5GR02 (/TAS) Q9BXR5 (/TAS) Q9BXR5 (/TAS) Q9Y2C9 (/TAS)
Pattern recognition receptor signaling pathway GO:0002221
Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
7 A0A2R8QF98 (/IDA) A0A2R8RTN4 (/IDA) B3DIC1 (/IDA) B3DJL6 (/IDA) F1QMN8 (/IDA) Q6TQG7 (/IDA) Q6TQG8 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
7 A0A096MKA9 (/TAS) G3V695 (/TAS) O60603 (/TAS) O60603 (/TAS) Q15399 (/TAS) Q6P690 (/TAS) Q9Y2C9 (/TAS)
Microglial cell activation GO:0001774
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
5 A0A096MKA9 (/IDA) E9PTD9 (/IDA) G3V695 (/IDA) Q6P690 (/IDA) Q6YGU2 (/IDA)
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
5 A0A096MKA9 (/IMP) E9PTD9 (/IMP) G3V695 (/IMP) Q6P690 (/IMP) Q6YGU2 (/IMP)
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
5 Q2XQ10 (/NAS) Q5ZJ34 (/NAS) Q9DD78 (/NAS) Q9DD78 (/NAS) Q9DGB6 (/NAS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
5 A0A096MKA9 (/IDA) E9PTD9 (/IDA) G3V695 (/IDA) Q6P690 (/IDA) Q6YGU2 (/IDA)
Response to bacterial lipoprotein GO:0032493
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus.
5 A0A096MKA9 (/IDA) E9PTD9 (/IDA) G3V695 (/IDA) Q6P690 (/IDA) Q6YGU2 (/IDA)
Nitric oxide metabolic process GO:0046209
The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
5 A0A096MKA9 (/IDA) E9PTD9 (/IDA) G3V695 (/IDA) Q6P690 (/IDA) Q6YGU2 (/IDA)
Microglial cell activation GO:0001774
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
4 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Cell activation GO:0001775
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
4 O60603 (/IDA) O60603 (/IDA) Q15399 (/IDA) Q9Y2C9 (/IDA)
Cell activation GO:0001775
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
4 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
4 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
4 O60603 (/TAS) O60603 (/TAS) Q15399 (/TAS) Q9Y2C9 (/TAS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
4 E9PTD9 (/NAS) Q6YGU2 (/NAS) Q9BXR5 (/NAS) Q9BXR5 (/NAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
4 O60603 (/TAS) O60603 (/TAS) Q15399 (/TAS) Q9Y2C9 (/TAS)
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
4 A0A2R8QF98 (/IDA) B3DIC1 (/IDA) F1QMN8 (/IDA) Q6TQG8 (/IDA)
Response to bacterial lipoprotein GO:0032493
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus.
4 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Toll-like receptor 2 signaling pathway GO:0034134
Any series of molecular signals generated as a consequence of binding to toll-like receptor 2.
4 A5H0S2 (/TAS) Q5WA51 (/TAS) Q9DD78 (/TAS) Q9DD78 (/TAS)
MyD88-dependent toll-like receptor signaling pathway GO:0002755
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
3 Q6R5N8 (/IGI) Q9EPW9 (/IGI) Q9QUN7 (/IGI)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
3 Q9EPQ1 (/IMP) Q9EPQ1 (/IMP) Q9QUN7 (/IMP)
Activation of NF-kappaB-inducing kinase activity GO:0007250
The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.
3 Q9EPQ1 (/NAS) Q9EPQ1 (/NAS) Q9Y2C9 (/NAS)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
3 A0A2R8RTN4 (/IDA) B3DJL6 (/IDA) Q6TQG7 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 O60603 (/IMP) O60603 (/IMP) Q9EPW9 (/IMP)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
3 O60603 (/IDA) O60603 (/IDA) Q9QUN7 (/IDA)
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
3 O60602 (/IDA) O60603 (/IDA) O60603 (/IDA)
Positive regulation of toll-like receptor signaling pathway GO:0034123
Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.
3 O60602 (/IDA) O60603 (/IDA) O60603 (/IDA)
Toll-like receptor TLR1:TLR2 signaling pathway GO:0038123
A series of molecular signals initiated by the binding of a heterodimeric TLR1:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
3 O60603 (/TAS) O60603 (/TAS) Q15399 (/TAS)
Toll-like receptor TLR6:TLR2 signaling pathway GO:0038124
A series of molecular signals initiated by the binding of a heterodimeric TLR6:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
3 O60603 (/TAS) O60603 (/TAS) Q9Y2C9 (/TAS)
Macrophage activation GO:0042116
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
3 Q15399 (/NAS) Q9EPQ1 (/NAS) Q9EPQ1 (/NAS)
Detection of triacyl bacterial lipopeptide GO:0042495
The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups.
3 O60603 (/IDA) O60603 (/IDA) Q15399 (/IDA)
Detection of triacyl bacterial lipopeptide GO:0042495
The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups.
3 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9QUN7 (/ISO)
Detection of diacyl bacterial lipopeptide GO:0042496
The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups.
3 O60603 (/IDA) O60603 (/IDA) Q9Y2C9 (/IDA)
Positive regulation of tumor necrosis factor biosynthetic process GO:0042535
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
3 Q9EPQ1 (/IMP) Q9EPQ1 (/IMP) Q9QUN7 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
3 O60603 (/TAS) O60603 (/TAS) Q9QUN7 (/TAS)
Positive regulation of interleukin-6 biosynthetic process GO:0045410
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.
3 Q15399 (/ISS) Q9EPW9 (/ISS) Q9Y2C9 (/ISS)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
3 Q0ZUL9 (/ISS) Q704V6 (/ISS) Q9Y2C9 (/ISS)
Cellular response to bacterial lipopeptide GO:0071221
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus.
3 O60603 (/TAS) O60603 (/TAS) Q9QUN7 (/TAS)
Cellular response to lipoteichoic acid GO:0071223
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
3 O60603 (/IMP) O60603 (/IMP) Q9QUN7 (/IMP)
Cellular response to diacyl bacterial lipopeptide GO:0071726
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus.
3 O60603 (/IDA) O60603 (/IDA) Q9Y2C9 (/IDA)
Cellular response to triacyl bacterial lipopeptide GO:0071727
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus.
3 O60603 (/IDA) O60603 (/IDA) Q15399 (/IDA)
Cellular response to triacyl bacterial lipopeptide GO:0071727
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus.
3 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9QUN7 (/ISO)
Positive regulation of NLRP3 inflammasome complex assembly GO:1900227
Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly.
3 Q0ZUL9 (/ISS) Q704V6 (/ISS) Q9Y2C9 (/ISS)
Positive regulation of interleukin-8 secretion GO:2000484
Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion.
3 O60603 (/IGI) O60603 (/IGI) Q15399 (/IGI)
Positive regulation of interleukin-8 secretion GO:2000484
Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion.
3 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9QUN7 (/ISO)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 E9PTD9 (/IEP) Q6YGU2 (/IEP)
Cytokine secretion involved in immune response GO:0002374
The regulated release of cytokines from a cell that contributes to an immune response.
2 O60603 (/IMP) O60603 (/IMP)
Leukotriene metabolic process GO:0006691
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
2 E9PTD9 (/IDA) Q6YGU2 (/IDA)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
2 O60603 (/TAS) O60603 (/TAS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 Q9EPW9 (/ISO) Q9QUN7 (/ISO)
I-kappaB phosphorylation GO:0007252
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2 O60603 (/IDA) O60603 (/IDA)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
2 O60603 (/ISS) O60603 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 E9PTD9 (/IDA) Q6YGU2 (/IDA)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
2 C0LP03 (/IEP) G3V6F8 (/IEP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
2 Q6R5P0 (/IMP) Q9QUN7 (/IMP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
2 E9PTD9 (/IEP) Q6YGU2 (/IEP)
Microglia development GO:0014005
The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
2 O60603 (/ISS) O60603 (/ISS)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
2 O60603 (/IMP) O60603 (/IMP)
Central nervous system myelin formation GO:0032289
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.
2 E9PTD9 (/IDA) Q6YGU2 (/IDA)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 E9PTD9 (/IEP) Q6YGU2 (/IEP)
Detection of peptidoglycan GO:0032499
The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule.
2 F6SU23 (/TAS) Q5WA51 (/TAS)
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
2 E9PTD9 (/IEP) Q6YGU2 (/IEP)
Interleukin-10 production GO:0032613
The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 O60603 (/IDA) O60603 (/IDA)
Tumor necrosis factor production GO:0032640
The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 O60603 (/ISS) O60603 (/ISS)
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
2 O60603 (/IDA) O60603 (/IDA)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
2 O60603 (/ISS) O60603 (/ISS)
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
2 E9PTD9 (/IDA) Q6YGU2 (/IDA)
Positive regulation of interleukin-12 production GO:0032735
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
2 O60603 (/ISS) O60603 (/ISS)
Positive regulation of interleukin-18 production GO:0032741
Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.
2 O60603 (/ISS) O60603 (/ISS)
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
2 Q9JLF7 (/ISO) Q9QUN7 (/ISO)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
2 O60603 (/ISS) O60603 (/ISS)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 E9PTD9 (/IEP) Q6YGU2 (/IEP)
Positive regulation of toll-like receptor signaling pathway GO:0034123
Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.
2 Q9JLF7 (/ISO) Q9QUN7 (/ISO)
Positive regulation of toll-like receptor 2 signaling pathway GO:0034137
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
2 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO)
Toll-like receptor 5 signaling pathway GO:0034146
Any series of molecular signals generated as a consequence of binding to toll-like receptor 5.
2 O60602 (/TAS) Q5GR02 (/TAS)
Toll-like receptor 10 signaling pathway GO:0034166
Any series of molecular signals generated as a consequence of binding to toll-like receptor 10.
2 Q9BXR5 (/TAS) Q9BXR5 (/TAS)
Detection of bacterial lipoprotein GO:0042494
The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs).
2 F6SU23 (/TAS) Q5WA51 (/TAS)
Detection of triacyl bacterial lipopeptide GO:0042495
The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups.
2 Q9EPQ1 (/NAS) Q9EPQ1 (/NAS)
Detection of diacyl bacterial lipopeptide GO:0042496
The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups.
2 Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 Q5ZJ34 (/TAS) Q9Y2C9 (/TAS)
Defense response to protozoan GO:0042832
Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
2 Q6QNU9 (/IMP) Q6QNU9 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 O60603 (/TAS) O60603 (/TAS)
Positive regulation of interleukin-6 biosynthetic process GO:0045410
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.
2 Q9EPQ1 (/IMP) Q9EPQ1 (/IMP)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
2 C0LP03 (/IDA) G3V6F8 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O60603 (/ISS) O60603 (/ISS)
Nitric oxide metabolic process GO:0046209
The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
2 Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
2 E9PTD9 (/IDA) Q6YGU2 (/IDA)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
2 O60603 (/IC) O60603 (/IC)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
2 Q9EPW9 (/IGI) Q9QUN7 (/IGI)
Negative regulation of phagocytosis GO:0050765
Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
2 O60603 (/ISS) O60603 (/ISS)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
2 O60603 (/IDA) O60603 (/IDA)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 O60603 (/IDA) O60603 (/IDA)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
2 O60603 (/ISS) O60603 (/ISS)
Negative regulation of synapse assembly GO:0051964
Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
2 O60603 (/ISS) O60603 (/ISS)
Response to fatty acid GO:0070542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
2 E9PTD9 (/IDA) Q6YGU2 (/IDA)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 C0LP03 (/IEP) G3V6F8 (/IEP)
Cellular response to lipoteichoic acid GO:0071223
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
2 O60603 (/IDA) O60603 (/IDA)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
2 O60603 (/IDA) O60603 (/IDA)
Cellular response to diacyl bacterial lipopeptide GO:0071726
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus.
2 Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
2 O60603 (/IDA) O60603 (/IDA)
Positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974
Any process that activates or increases the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus.
2 O60603 (/IDA) O60603 (/IDA)
Response to molecule of fungal origin GO:0002238
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
1 Q9QUN7 (/IMP)
Cytokine secretion involved in immune response GO:0002374
The regulated release of cytokines from a cell that contributes to an immune response.
1 Q9QUN7 (/ISO)
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
1 Q9QUN7 (/IMP)
Regulation of dendritic cell cytokine production GO:0002730
Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.
1 Q9QUN7 (/IDA)
Cell surface pattern recognition receptor signaling pathway GO:0002752
Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
1 Q9QUN7 (/IMP)
MyD88-dependent toll-like receptor signaling pathway GO:0002755
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
1 Q9Y2C9 (/ISS)
Leukotriene metabolic process GO:0006691
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
1 Q9QUN7 (/ISO)
I-kappaB phosphorylation GO:0007252
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
1 Q9QUN7 (/ISO)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
1 Q9QUN7 (/IGI)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9QUN7 (/ISO)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q6R5N8 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9EPW9 (/IGI)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9QUN7 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9Y2C9 (/ISS)
Microglia development GO:0014005
The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
1 Q9QUN7 (/IGI)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
1 Q9QUN7 (/ISO)
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
1 Q9QUN7 (/IGI)
Central nervous system myelin formation GO:0032289
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.
1 Q9QUN7 (/ISO)
Response to peptidoglycan GO:0032494
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.
1 Q9QUN7 (/IMP)
Interleukin-10 production GO:0032613
The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
1 Q9QUN7 (/ISO)
Tumor necrosis factor production GO:0032640
The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
1 Q9QUN7 (/IGI)
Negative regulation of interleukin-12 production GO:0032695
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
1 Q9QUN7 (/IMP)
Negative regulation of interleukin-17 production GO:0032700
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
1 Q9QUN7 (/IMP)
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
1 Q9QUN7 (/IMP)
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
1 Q9QUN7 (/ISO)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
1 Q9QUN7 (/IDA)
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
1 Q9QUN7 (/ISO)
Positive regulation of interleukin-12 production GO:0032735
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
1 Q9QUN7 (/IDA)
Positive regulation of interleukin-18 production GO:0032741
Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.
1 Q9QUN7 (/IDA)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
1 Q9QUN7 (/IMP)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
1 Q9QUN7 (/ISO)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
1 Q9QUN7 (/IDA)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
1 Q9QUN7 (/IMP)
Negative regulation of toll-like receptor 2 signaling pathway GO:0034136
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
1 Q9Y2C9 (/IGI)
Negative regulation of toll-like receptor 2 signaling pathway GO:0034136
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
1 Q9EPW9 (/ISO)
Positive regulation of toll-like receptor 2 signaling pathway GO:0034137
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
1 Q15399 (/IGI)
Toll-like receptor 13 signaling pathway GO:0034178
Any series of molecular signals generated as a consequence of binding to toll-like receptor 13.
1 Q6R5N8 (/IDA)
TRIF-dependent toll-like receptor signaling pathway GO:0035666
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
1 Q9EPW9 (/IGI)
TRIF-dependent toll-like receptor signaling pathway GO:0035666
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
1 Q9Y2C9 (/ISS)
Toll-like receptor 15 signaling pathway GO:0035681
Any series of molecular signals generated as a consequence of binding to toll-like receptor 15.
1 Q2XQ10 (/TAS)
Toll-like receptor 21 signaling pathway GO:0035682
Any series of molecular signals generated as a consequence of binding to toll-like receptor 21.
1 Q5ZJ34 (/TAS)
Detection of bacterial lipoprotein GO:0042494
The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs).
1 Q9DGB6 (/NAS)
Positive regulation of tumor necrosis factor biosynthetic process GO:0042535
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
1 Q15399 (/ISS)
Positive regulation of macrophage activation GO:0043032
Any process that stimulates, induces or increases the rate of macrophage activation.
1 Q9EPW9 (/IGI)
Positive regulation of macrophage activation GO:0043032
Any process that stimulates, induces or increases the rate of macrophage activation.
1 Q9Y2C9 (/ISS)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 Q9Y2C9 (/IDA)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 Q9EPW9 (/ISO)
Regulation of MAPK cascade GO:0043408
Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
1 Q6R5N8 (/IGI)
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
1 Q9Y2C9 (/IDA)
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
1 Q9EPW9 (/ISO)
Negative regulation of growth of symbiont in host GO:0044130
Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction.
1 Q9QUN7 (/IMP)
Positive regulation of interleukin-12 biosynthetic process GO:0045084
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.
1 Q9EPW9 (/NAS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q6R5N8 (/IDA)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q9EPW9 (/IGI)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q9QUN7 (/IMP)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q9JLF7 (/ISO)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q9Y2C9 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9QUN7 (/IDA)
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
1 Q9QUN7 (/ISO)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
1 Q9EPW9 (/IDA)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
1 Q9QUN7 (/IGI)
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
1 Q9QUN7 (/IGI)
Positive regulation of interleukin-1 beta biosynthetic process GO:0050725
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta.
1 Q5GR02 (/IEP)
Negative regulation of phagocytosis GO:0050765
Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
1 Q9QUN7 (/IGI)
Negative regulation of phagocytosis GO:0050765
Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
1 Q9QUN7 (/IMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 Q2XQ10 (/TAS)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q9QUN7 (/IMP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q9QUN7 (/ISO)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 Q9Y2C9 (/IGI)
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
1 Q9QUN7 (/IDA)
Negative regulation of synapse assembly GO:0051964
Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 Q9QUN7 (/IGI)
Induction by symbiont of defense-related host nitric oxide production GO:0052063
The activation by an organism of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 Q9QUN7 (/IMP)
Positive regulation of macrophage cytokine production GO:0060907
Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
1 Q9QUN7 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q9QUN7 (/IMP)
Response to fatty acid GO:0070542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
1 Q9QUN7 (/ISO)
Cellular response to bacterial lipopeptide GO:0071221
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus.
1 Q9QUN7 (/IMP)
Cellular response to lipoteichoic acid GO:0071223
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
1 Q9QUN7 (/ISO)
Cellular response to peptidoglycan GO:0071224
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.
1 Q9QUN7 (/IMP)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 O60602 (/IEP)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
1 Q9QUN7 (/ISO)
Cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus.
1 Q9EPW9 (/IGI)
Cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus.
1 Q9Y2C9 (/ISS)
Positive regulation of cytokine production involved in inflammatory response GO:1900017
Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
1 Q9EPW9 (/IGI)
Positive regulation of cytokine production involved in inflammatory response GO:1900017
Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
1 Q9Y2C9 (/ISS)
Positive regulation of NLRP3 inflammasome complex assembly GO:1900227
Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly.
1 Q9EPW9 (/IDA)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
1 Q9QUN7 (/IMP)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
1 Q9QUN7 (/ISO)
Regulation of hematopoietic progenitor cell differentiation GO:1901532
Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.
1 A0A2R8QLW9 (/IGI)
Positive regulation of hematopoietic progenitor cell differentiation GO:1901534
Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.
1 A0A2R8QLW9 (/IMP)
Positive regulation of oxidative stress-induced neuron death GO:1903223
Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death.
1 Q9EPW9 (/IGI)
Positive regulation of oxidative stress-induced neuron death GO:1903223
Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death.
1 Q9Y2C9 (/ISS)
Positive regulation of reactive oxygen species biosynthetic process GO:1903428
Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process.
1 Q9EPW9 (/IMP)
Positive regulation of reactive oxygen species biosynthetic process GO:1903428
Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process.
1 Q9Y2C9 (/ISS)
Positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974
Any process that activates or increases the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus.
1 Q9QUN7 (/ISO)
Positive regulation of xenophagy GO:1904417
Any process that activates or increases the frequency, rate or extent of xenophagy.
1 Q9QUN7 (/IMP)
Negative regulation of tumor necrosis factor secretion GO:1904468
Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor secretion.
1 Q9EPW9 (/IGI)
Positive regulation of tumor necrosis factor secretion GO:1904469
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.
1 Q9QUN7 (/IGI)
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
1 Q9Y2C9 (/IGI)
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
1 Q9EPW9 (/ISO)
Negative regulation of interleukin-8 secretion GO:2000483
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion.
1 Q9Y2C9 (/IGI)
Negative regulation of interleukin-8 secretion GO:2000483
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion.
1 Q9EPW9 (/ISO)

There are 39 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
27 B2LT61 (/ISS) B2LT62 (/ISS) B2LT64 (/ISS) B2LT65 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y614 (/ISS) B3Y615 (/ISS)
(17 more)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
27 B2LT61 (/ISS) B2LT62 (/ISS) B2LT64 (/ISS) B2LT65 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y613 (/ISS) B3Y614 (/ISS) B3Y615 (/ISS)
(17 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
13 A5H0S2 (/TAS) O60602 (/TAS) O60603 (/TAS) O60603 (/TAS) Q15399 (/TAS) Q2XQ10 (/TAS) Q5GR02 (/TAS) Q5WA51 (/TAS) Q9BXR5 (/TAS) Q9BXR5 (/TAS)
(3 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
4 A0A2R8QF98 (/IDA) B3DIC1 (/IDA) F1QMN8 (/IDA) Q6TQG8 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 O60603 (/IDA) O60603 (/IDA) Q15399 (/IDA) Q9Y2C9 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 O60603 (/TAS) O60603 (/TAS) Q15399 (/TAS) Q9Y2C9 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 E9PTD9 (/IDA) O60603 (/IDA) O60603 (/IDA) Q6YGU2 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
4 O60603 (/IDA) O60603 (/IDA) Q15399 (/IDA) Q9Y2C9 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
4 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9EPW9 (/ISO) Q9QUN7 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O60603 (/IDA) O60603 (/IDA) Q6R5N8 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O60603 (/IDA) O60603 (/IDA) Q9QUN7 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q15399 (/NAS) Q9EPQ1 (/NAS) Q9EPQ1 (/NAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 A0A096MKA9 (/TAS) G3V695 (/TAS) Q6P690 (/TAS)
Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354
A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2).
3 O60603 (/IDA) O60603 (/IDA) Q15399 (/IDA)
Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354
A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2).
3 Q9EPQ1 (/ISO) Q9EPQ1 (/ISO) Q9QUN7 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 C0LP03 (/IDA) G3V6F8 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9BXR5 (/TAS) Q9BXR5 (/TAS)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
2 O60603 (/TAS) O60603 (/TAS)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
2 O60603 (/IDA) O60603 (/IDA)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
2 E9PTD9 (/IDA) Q6YGU2 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
2 E9PTD9 (/IDA) Q6YGU2 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
2 Q9EPQ1 (/NAS) Q9EPQ1 (/NAS)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 Q9Y2C9 (/IPI)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 Q9EPW9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9QUN7 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q6R5N8 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9QUN7 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q9QUN7 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q9QUN7 (/ISO)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 Q5ZJ34 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9JLF7 (/ISO)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q9QUN7 (/ISO)
Toll-like receptor 2-Toll-like receptor 6 protein complex GO:0035355
A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6).
1 Q9EPW9 (/IDA)
Toll-like receptor 2-Toll-like receptor 6 protein complex GO:0035355
A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6).
1 Q9QUN7 (/IPI)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
1 Q9QUN7 (/ISO)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9Y2C9 (/IPI)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9EPW9 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 Q9QUN7 (/ISO)