The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24: Glutathione S-transferase A4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
34 A7E2P6 (/IDA) C8BLR1 (/IDA) C8BLR1 (/IDA) C8BLR2 (/IDA) C8BLR2 (/IDA) C8BLR3 (/IDA) C8BLR4 (/IDA) C8BLR4 (/IDA) C8BLR4 (/IDA) C8BLR5 (/IDA)
(24 more)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
22 O18879 (/ISS) P09210 (/ISS) P09210 (/ISS) P10648 (/ISS) P13745 (/ISS) P24472 (/ISS) P26697 (/ISS) P30115 (/ISS) P51781 (/ISS) P80894 (/ISS)
(12 more)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
9 O15217 (/TAS) O15217 (/TAS) O15217 (/TAS) O15217 (/TAS) O15217 (/TAS) P09210 (/TAS) P09210 (/TAS) P24472 (/TAS) Q16772 (/TAS)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
8 P00502 (/IDA) P00502 (/IDA) P04903 (/IDA) P04904 (/IDA) P04904 (/IDA) P14942 (/IDA) P14942 (/IDA) P46418 (/IDA)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
8 P00502 (/IDA) P00502 (/IDA) P04903 (/IDA) P04904 (/IDA) P04904 (/IDA) P14942 (/IDA) P14942 (/IDA) P46418 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 O15217 (/IPI) O15217 (/IPI) O15217 (/IPI) O15217 (/IPI) O15217 (/IPI) P09210 (/IPI) P09210 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 O15217 (/IPI) O15217 (/IPI) O15217 (/IPI) O15217 (/IPI) O15217 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 O15217 (/IPI) O15217 (/IPI) O15217 (/IPI) O15217 (/IPI) O15217 (/IPI)
Steroid delta-isomerase activity GO:0004769
Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid.
4 P00502 (/ISS) P00502 (/ISS) P13745 (/ISS) Q28035 (/ISS)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
3 P10648 (/ISO) P13745 (/ISO) P24472 (/ISO)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
3 P10648 (/ISO) P13745 (/ISO) P24472 (/ISO)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
2 P08263 (/NAS) P08263 (/NAS)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
2 P08263 (/IDA) P08263 (/IDA)
Steroid delta-isomerase activity GO:0004769
Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid.
2 P08263 (/IDA) P08263 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P00502 (/IDA) P00502 (/IDA)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
1 P30115 (/IMP)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
1 P13745 (/ISA)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 P24472 (/ISO)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
22 O18879 (/ISS) P09210 (/ISS) P09210 (/ISS) P10648 (/ISS) P13745 (/ISS) P24472 (/ISS) P26697 (/ISS) P30115 (/ISS) P51781 (/ISS) P80894 (/ISS)
(12 more)
Aflatoxin B1 metabolic process GO:0043390
The chemical reactions and pathways involving aflatoxin B1, a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by various species from the Aspergillus group of fungi.
17 C8BLR1 (/IDA) C8BLR1 (/IDA) C8BLR2 (/IDA) C8BLR2 (/IDA) C8BLR3 (/IDA) C8BLR4 (/IDA) C8BLR4 (/IDA) C8BLR4 (/IDA) C8BLR5 (/IDA) C8BLR5 (/IDA)
(7 more)
Detoxification GO:0098754
Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
17 C8BLR1 (/IDA) C8BLR1 (/IDA) C8BLR2 (/IDA) C8BLR2 (/IDA) C8BLR3 (/IDA) C8BLR4 (/IDA) C8BLR4 (/IDA) C8BLR4 (/IDA) C8BLR5 (/IDA) C8BLR5 (/IDA)
(7 more)
Glutathione derivative biosynthetic process GO:1901687
The chemical reactions and pathways resulting in the formation of glutathione derivative.
10 O15217 (/TAS) O15217 (/TAS) O15217 (/TAS) O15217 (/TAS) O15217 (/TAS) P08263 (/TAS) P08263 (/TAS) P09210 (/TAS) P09210 (/TAS) Q16772 (/TAS)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
7 O15217 (/IDA) O15217 (/IDA) O15217 (/IDA) O15217 (/IDA) O15217 (/IDA) P08263 (/IDA) P08263 (/IDA)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
7 O15217 (/IDA) O15217 (/IDA) O15217 (/IDA) O15217 (/IDA) O15217 (/IDA) P14942 (/IDA) P14942 (/IDA)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
6 P00502 (/IEP) P00502 (/IEP) P04903 (/IEP) P04904 (/IEP) P04904 (/IEP) P46418 (/IEP)
Xenobiotic catabolic process GO:0042178
The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
6 P00502 (/IDA) P00502 (/IDA) P04903 (/IDA) P04904 (/IDA) P04904 (/IDA) P46418 (/IDA)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
5 P00502 (/IEP) P00502 (/IEP) P04904 (/IEP) P04904 (/IEP) P46418 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
5 P00502 (/NAS) P00502 (/NAS) P04904 (/NAS) P04904 (/NAS) P46418 (/NAS)
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
4 P00502 (/ISS) P00502 (/ISS) P13745 (/ISS) Q28035 (/ISS)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
4 P08263 (/IEP) P08263 (/IEP) P09210 (/IEP) P09210 (/IEP)
Glutathione derivative biosynthetic process GO:1901687
The chemical reactions and pathways resulting in the formation of glutathione derivative.
4 P00502 (/ISS) P00502 (/ISS) P13745 (/ISS) Q28035 (/ISS)
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
2 P08263 (/IDA) P08263 (/IDA)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
2 P10648 (/IEP) P13745 (/IEP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
2 P14942 (/IEP) P14942 (/IEP)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
2 P14942 (/IEP) P14942 (/IEP)
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
2 P14942 (/IEP) P14942 (/IEP)
Response to stilbenoid GO:0035634
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.
2 P10648 (/IEP) P13745 (/IEP)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P09210 (/TAS) P09210 (/TAS)
Linoleic acid metabolic process GO:0043651
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
2 P08263 (/IDA) P08263 (/IDA)
Cellular response to lithium ion GO:0071285
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
2 P14942 (/IEP) P14942 (/IEP)
Glutathione derivative biosynthetic process GO:1901687
The chemical reactions and pathways resulting in the formation of glutathione derivative.
2 P08263 (/IDA) P08263 (/IDA)
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
1 P30115 (/IEP)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
1 P13745 (/ISA)
Aflatoxin catabolic process GO:0046223
The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
1 P30115 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
33 A0A140VJK4 (/IDA) A0A140VJK4 (/IDA) A0A140VKE2 (/IDA) A0A140VKE2 (/IDA) C8BLR1 (/IDA) C8BLR1 (/IDA) C8BLR2 (/IDA) C8BLR2 (/IDA) C8BLR3 (/IDA) C8BLR4 (/IDA)
(23 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 O15217 (/TAS) O15217 (/TAS) O15217 (/TAS) O15217 (/TAS) O15217 (/TAS) P08263 (/TAS) P08263 (/TAS) P09210 (/TAS) P09210 (/TAS) Q16772 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P00502 (/IDA) P00502 (/IDA) P04903 (/IDA) P04904 (/IDA) P04904 (/IDA) P46418 (/IDA)
Nuclear outer membrane GO:0005640
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
6 P00502 (/IDA) P00502 (/IDA) P04903 (/IDA) P04904 (/IDA) P04904 (/IDA) P46418 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
6 P08263 (/HDA) P08263 (/HDA) P09210 (/HDA) P09210 (/HDA) Q16772 (/HDA) Q7RTV2 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P10648 (/ISO) P13745 (/ISO) P30115 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P14942 (/IDA) P14942 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P14942 (/IDA) P14942 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P09210 (/TAS) P09210 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q08392 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P24472 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P24472 (/ISO)