The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leucine Aminopeptidase, subunit E, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: O-acetyl-ADP-ribose deacetylase MACROD2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
90 P0A8D6 (/IPI) P0A8D6 (/IPI) P0A8D6 (/IPI) P0A8D6 (/IPI) P0A8D6 (/IPI) P0A8D6 (/IPI) P0A8D6 (/IPI) P0A8D6 (/IPI) P0A8D6 (/IPI) P0A8D6 (/IPI)
(80 more)
Endoribonuclease inhibitor activity GO:0060698
Stops, prevents or reduces the activity of an endoribonuclease, any enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
90 P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA)
(80 more)
O-acetyl-ADP-ribose deacetylase activity GO:0061463
Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate.
90 P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA) P0A8D6 (/IDA)
(80 more)
Hydrolase activity, acting on glycosyl bonds GO:0016798
Catalysis of the hydrolysis of any glycosyl bond.
5 Q2KHU5 (/ISS) Q3UYG8 (/ISS) Q6PAV8 (/ISS) Q8K4G6 (/ISS) Q922B1 (/ISS)
ADP-ribosylglutamate hydrolase activity GO:0140293
Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-
5 Q2KHU5 (/ISS) Q3UYG8 (/ISS) Q6PAV8 (/ISS) Q8K4G6 (/ISS) Q922B1 (/ISS)
Hydrolase activity, acting on glycosyl bonds GO:0016798
Catalysis of the hydrolysis of any glycosyl bond.
2 A1Z1Q3 (/IDA) Q9BQ69 (/IDA)
Hydrolase activity, acting on glycosyl bonds GO:0016798
Catalysis of the hydrolysis of any glycosyl bond.
2 Q3UYG8 (/ISO) Q922B1 (/ISO)
Deacetylase activity GO:0019213
Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
2 A1Z1Q3 (/IDA) Q9BQ69 (/IDA)
Deacetylase activity GO:0019213
Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
2 Q3UYG8 (/ISO) Q922B1 (/ISO)
ADP-ribosylglutamate hydrolase activity GO:0140293
Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-
2 A1Z1Q3 (/IDA) Q9BQ69 (/IDA)
ADP-ribosylglutamate hydrolase activity GO:0140293
Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-
2 Q3UYG8 (/ISO) Q922B1 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9BQ69 (/IPI)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of endoribonuclease activity GO:0060702
Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
90 P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP)
(80 more)
Regulation of single-species biofilm formation on inanimate substrate GO:1900231
Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
90 P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP) P0A8D6 (/IMP)
(80 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
5 Q2KHU5 (/ISS) Q3UYG8 (/ISS) Q6PAV8 (/ISS) Q8K4G6 (/ISS) Q922B1 (/ISS)
Protein de-ADP-ribosylation GO:0051725
The process of removing one or more ADP-ribose residues from a protein.
5 Q2KHU5 (/ISS) Q3UYG8 (/ISS) Q6PAV8 (/ISS) Q8K4G6 (/ISS) Q922B1 (/ISS)
Peptidyl-glutamate ADP-deribosylation GO:0140291
The removal of ADP-ribose from ADP-ribosylglutamate.
5 Q2KHU5 (/ISS) Q3UYG8 (/ISS) Q6PAV8 (/ISS) Q8K4G6 (/ISS) Q922B1 (/ISS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
2 A1Z1Q3 (/IMP) Q9BQ69 (/IMP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
2 Q3UYG8 (/ISO) Q922B1 (/ISO)
Purine nucleoside metabolic process GO:0042278
The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
2 A1Z1Q3 (/IDA) Q9BQ69 (/IDA)
Purine nucleoside metabolic process GO:0042278
The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
2 Q3UYG8 (/ISO) Q922B1 (/ISO)
Protein de-ADP-ribosylation GO:0051725
The process of removing one or more ADP-ribose residues from a protein.
2 A1Z1Q3 (/IDA) Q9BQ69 (/IDA)
Protein de-ADP-ribosylation GO:0051725
The process of removing one or more ADP-ribose residues from a protein.
2 Q3UYG8 (/ISO) Q922B1 (/ISO)
Peptidyl-glutamate ADP-deribosylation GO:0140291
The removal of ADP-ribose from ADP-ribosylglutamate.
2 A1Z1Q3 (/IDA) Q9BQ69 (/IDA)
Peptidyl-glutamate ADP-deribosylation GO:0140291
The removal of ADP-ribose from ADP-ribosylglutamate.
2 Q3UYG8 (/ISO) Q922B1 (/ISO)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q3UYG8 (/IEP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 Q3UYG8 (/IEP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q2KHU5 (/ISS) Q3UYG8 (/ISS) Q6PAV8 (/ISS) Q8K4G6 (/ISS) Q922B1 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 A1Z1Q3 (/IDA) Q9BQ69 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q3UYG8 (/ISO) Q922B1 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9BQ69 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q922B1 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 A1Z1Q3 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q3UYG8 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q922B1 (/HDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 A1Z1Q3 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q3UYG8 (/ISO)