The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cypl, domain I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Cypl, domain I

This superfamily contains domain I of Cypl (extracytoplasmic thiamine-binding lipoprotein). Literature suggests that the high affinity transport system protein p37 specific to Mycoplasma species (as it currently appears in pfam and InterPro entries) was renamed the extracytoplasmic thiamine-binding lipoprotein. The p37 gene is part of an operon encoding two additional proteins which are highly similar to components of the periplasmic binding-protein-dependent transport systems of Gram-negative bacteria. It has been suggested that p37 is part of a homologous, high-affinity transport system in M. hyorhinis, a Gram-positive bacterium. Its structure indicates that it is a thiamine pyrophosphate-binding protein.

The monomer is a mixed alpha/beta fold split into two globular domains (Domains I and II) connected by two linker regions and the C-terminal helix. This entry represents Domain I, which consists of a six-stranded beta-sheet flanked by seven helices.

PFAM:PF06646, INTERPRO:IPR010592,DOI:10.1128/JB.01680-08,DOI:10.1002/prot.22900

GO Diversity

Unique GO annotations
4 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
69 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 5
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 4
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 4
Taxonomy
Unique Species: 69