The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Bifunctional purine biosynthesis protein PURH

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
IMP cyclohydrolase activity GO:0003937
Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.
9 O35567 (/IDA) O74928 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P54113 (/IDA)
Phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO:0004643
Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.
9 O35567 (/IDA) O74928 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P54113 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 O35567 (/IPI) P38009 (/IPI) P38009 (/IPI) P38009 (/IPI) P38009 (/IPI) P38009 (/IPI) P38009 (/IPI) P54113 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
6 P31335 (/IPI) P31939 (/IPI) P31939 (/IPI) P31939 (/IPI) P31939 (/IPI) P31939 (/IPI)
IMP cyclohydrolase activity GO:0003937
Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.
5 P31939 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS)
Phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO:0004643
Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.
5 P31939 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
5 P31939 (/HDA) P31939 (/HDA) P31939 (/HDA) P31939 (/HDA) P31939 (/HDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 O35567 (/ISS) Q0VCK0 (/ISS) Q5R5C2 (/ISS) Q9CWJ9 (/ISS)
IMP cyclohydrolase activity GO:0003937
Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.
1 O74928 (/IMP)
IMP cyclohydrolase activity GO:0003937
Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.
1 Q9CWJ9 (/ISO)
IMP cyclohydrolase activity GO:0003937
Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.
1 C8V8H7 (/RCA)
Phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO:0004643
Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.
1 O74928 (/IMP)
Phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO:0004643
Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.
1 Q9CWJ9 (/ISO)
Phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO:0004643
Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.
1 C8V8H7 (/RCA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9CWJ9 (/ISO)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
'de novo' IMP biosynthetic process GO:0006189
The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
8 O35567 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P54113 (/IDA)
'de novo' IMP biosynthetic process GO:0006189
The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
8 O74928 (/IMP) P38009 (/IMP) P38009 (/IMP) P38009 (/IMP) P38009 (/IMP) P38009 (/IMP) P38009 (/IMP) P54113 (/IMP)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
7 P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P54113 (/IDA)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
7 P38009 (/IMP) P38009 (/IMP) P38009 (/IMP) P38009 (/IMP) P38009 (/IMP) P38009 (/IMP) P54113 (/IMP)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
5 P31939 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS)
Purine ribonucleoside monophosphate biosynthetic process GO:0009168
The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
5 P31939 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
2 Q95RT1 (/IMP) Q9VC18 (/IMP)
Brainstem development GO:0003360
The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.
1 O35567 (/IEP)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
1 C8V8H7 (/RCA)
IMP biosynthetic process GO:0006188
The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate.
1 O74928 (/IMP)
'de novo' IMP biosynthetic process GO:0006189
The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
1 Q9CWJ9 (/ISO)
'de novo' IMP biosynthetic process GO:0006189
The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
1 P31335 (/TAS)
Nucleoside metabolic process GO:0009116
The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).
1 O35567 (/IDA)
Nucleoside metabolic process GO:0009116
The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).
1 Q9CWJ9 (/ISO)
Cobalamin metabolic process GO:0009235
The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
1 O35567 (/TAS)
Ribonucleotide metabolic process GO:0009259
The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 O35567 (/IDA)
Ribonucleotide metabolic process GO:0009259
The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 Q9CWJ9 (/ISO)
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
1 O35567 (/IEP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 O35567 (/IEP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
1 O35567 (/IEP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 O35567 (/IEP)
Dihydrofolate metabolic process GO:0046452
The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate.
1 O35567 (/IDA)
Dihydrofolate metabolic process GO:0046452
The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate.
1 Q9CWJ9 (/ISO)
Tetrahydrofolate biosynthetic process GO:0046654
The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
1 O35567 (/IDA)
Tetrahydrofolate biosynthetic process GO:0046654
The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
1 Q9CWJ9 (/ISO)
Cellular response to interleukin-7 GO:0098761
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus.
1 Q9CWJ9 (/IDA)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
17 P31939 (/IDA) P31939 (/IDA) P31939 (/IDA) P31939 (/IDA) P31939 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA) P38009 (/IDA)
(7 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 P31939 (/IDA) P31939 (/IDA) P31939 (/IDA) P31939 (/IDA) P31939 (/IDA) V9HWH7 (/IDA) V9HWH7 (/IDA) V9HWH7 (/IDA) V9HWH7 (/IDA) V9HWH7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P31335 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS) P31939 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P38009 (/HDA) P38009 (/HDA) P38009 (/HDA) P38009 (/HDA) P38009 (/HDA) P38009 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 P31939 (/HDA) P31939 (/HDA) P31939 (/HDA) P31939 (/HDA) P31939 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 P31939 (/HDA) P31939 (/HDA) P31939 (/HDA) P31939 (/HDA) P31939 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9CWJ9 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O74928 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9CWJ9 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9CWJ9 (/ISO)