The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytidine Deaminase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Cytidine deaminase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytidine deaminase activity GO:0004126
Catalysis of the reaction: cytidine + H2O = uridine + NH3.
21 D4AC20 (/IDA) P32320 (/IDA) P32320 (/IDA) P32320 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA)
(11 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
11 P32320 (/IDA) P32320 (/IDA) P32320 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA)
(1 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
10 P56389 (/IPI) Q06549 (/IPI) Q06549 (/IPI) Q06549 (/IPI) Q06549 (/IPI) Q06549 (/IPI) Q06549 (/IPI) Q06549 (/IPI) Q06549 (/IPI) Q9VLR3 (/IPI)
Deoxycytidine deaminase activity GO:0047844
Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3.
10 P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) Q20628 (/IDA) Q22922 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P32320 (/IPI) P32320 (/IPI) P32320 (/IPI) Q20628 (/IPI)
Nucleoside binding GO:0001882
Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.
3 P32320 (/IDA) P32320 (/IDA) P32320 (/IDA)
Cytidine deaminase activity GO:0004126
Catalysis of the reaction: cytidine + H2O = uridine + NH3.
3 P56389 (/ISS) Q22922 (/ISS) Q54I82 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P32320 (/TAS) P32320 (/TAS) P32320 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 P32320 (/IDA) P32320 (/IDA) P32320 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q20628 (/IDA) Q22922 (/IDA)
Cytidine deaminase activity GO:0004126
Catalysis of the reaction: cytidine + H2O = uridine + NH3.
2 P56389 (/ISO) Q09190 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 P56389 (/ISS) Q54I82 (/ISS)
Nucleoside binding GO:0001882
Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.
1 P56389 (/ISO)
Nucleoside binding GO:0001882
Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.
1 P56389 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 P56389 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P56389 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P56389 (/ISS)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytidine deamination GO:0009972
The removal of amino group in the presence of water.
12 D4AC20 (/IDA) P32320 (/IDA) P32320 (/IDA) P32320 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA)
(2 more)
Deoxycytidine catabolic process GO:0006217
The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.
10 Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q20628 (/IDA) Q22922 (/IDA)
Cytidine catabolic process GO:0006216
The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside.
8 Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA)
Pyrimidine-containing compound salvage GO:0008655
Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis.
8 Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA)
Pyrimidine nucleobase salvage GO:0043100
Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis.
8 P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA)
Uridine biosynthetic process GO:0046109
The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.
8 P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA) P9WPH3 (/IDA)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
3 P32320 (/NAS) P32320 (/NAS) P32320 (/NAS)
Pyrimidine-containing compound salvage GO:0008655
Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis.
3 P32320 (/NAS) P32320 (/NAS) P32320 (/NAS)
Cytosine metabolic process GO:0019858
The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.
3 P32320 (/TAS) P32320 (/TAS) P32320 (/TAS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
3 P32320 (/IDA) P32320 (/IDA) P32320 (/IDA)
Pyrimidine nucleoside salvage GO:0043097
Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis.
3 P32320 (/TAS) P32320 (/TAS) P32320 (/TAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
3 P32320 (/TAS) P32320 (/TAS) P32320 (/TAS)
Negative regulation of nucleotide metabolic process GO:0045980
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
3 P32320 (/IDA) P32320 (/IDA) P32320 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
3 P32320 (/IDA) P32320 (/IDA) P32320 (/IDA)
RNA modification GO:0009451
The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.
2 Q20628 (/IDA) Q22922 (/IDA)
Cytidine deamination GO:0009972
The removal of amino group in the presence of water.
2 P56389 (/ISS) Q54I82 (/ISS)
Uridine biosynthetic process GO:0046109
The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.
2 Q20628 (/IGI) Q22922 (/IGI)
Pyrimidine nucleobase metabolic process GO:0006206
The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
1 Q09190 (/NAS)
Cytidine catabolic process GO:0006216
The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside.
1 Q54I82 (/ISS)
Deoxycytidine catabolic process GO:0006217
The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.
1 Q54I82 (/ISS)
Pyrimidine-containing compound salvage GO:0008655
Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis.
1 Q54I82 (/ISS)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 Q20628 (/IMP)
Cytidine deamination GO:0009972
The removal of amino group in the presence of water.
1 P56389 (/ISO)
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
1 Q22922 (/ISS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 P56389 (/ISO)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 P56389 (/ISS)
Negative regulation of nucleotide metabolic process GO:0045980
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
1 P56389 (/ISO)
Negative regulation of nucleotide metabolic process GO:0045980
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
1 P56389 (/ISS)
Response to cycloheximide GO:0046898
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes.
1 D4AC20 (/IEP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P56389 (/ISO)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P56389 (/ISS)
Cellular response to external biotic stimulus GO:0071217
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.
1 D4AC20 (/IEP)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q09190 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA) Q06549 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA) Q06549 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 P9WPH3 (/HDA) P9WPH3 (/HDA) P9WPH3 (/HDA) P9WPH3 (/HDA) P9WPH3 (/HDA) P9WPH3 (/HDA) P9WPH3 (/HDA) P9WPH3 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P32320 (/TAS) P32320 (/TAS) P32320 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P32320 (/NAS) P32320 (/NAS) P32320 (/NAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P32320 (/TAS) P32320 (/TAS) P32320 (/TAS)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
3 P32320 (/TAS) P32320 (/TAS) P32320 (/TAS)
Tertiary granule lumen GO:1904724
Any membrane-enclosed lumen that is part of a tertiary granule.
3 P32320 (/TAS) P32320 (/TAS) P32320 (/TAS)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
3 P32320 (/TAS) P32320 (/TAS) P32320 (/TAS)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 Q22922 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q54I82 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q54I82 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q09190 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 D4AC20 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P56389 (/ISO)