CATH Superfamily 3.30.70.580
Pseudouridine synthase I, catalytic domain, N-terminal subdomain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pseudouridine synthase I, catalytic domain, N-terminal subdomain
".
FunFam 2: tRNA pseudouridine synthase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 18 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
|
8 | Q12211 (/EXP) Q12211 (/EXP) Q12211 (/EXP) Q12211 (/EXP) Q12211 (/EXP) Q12211 (/EXP) Q9Y606 (/EXP) Q9Y606 (/EXP) |
|
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
|
8 | O94396 (/IDA) Q12211 (/IDA) Q12211 (/IDA) Q12211 (/IDA) Q12211 (/IDA) Q12211 (/IDA) Q12211 (/IDA) Q9WU56 (/IDA) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
6 | Q12211 (/HDA) Q12211 (/HDA) Q12211 (/HDA) Q12211 (/HDA) Q12211 (/HDA) Q12211 (/HDA) |
|
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
3 | Q4KM92 (/ISS) Q4KM92 (/ISS) Q9WU56 (/ISS) |
|
Steroid receptor RNA activator RNA binding GO:0002153
Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.
|
3 | Q4KM92 (/ISS) Q4KM92 (/ISS) Q9WU56 (/ISS) |
|
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
|
3 | Q9WU56 (/IMP) Q9Y606 (/IMP) Q9Y606 (/IMP) |
|
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
|
3 | O22928 (/TAS) Q9LN29 (/TAS) Q9SGS1 (/TAS) |
|
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
2 | Q9Y606 (/IDA) Q9Y606 (/IDA) |
|
Steroid receptor RNA activator RNA binding GO:0002153
Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.
|
2 | Q9Y606 (/IDA) Q9Y606 (/IDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | Q9Y606 (/HDA) Q9Y606 (/HDA) |
|
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
|
2 | O94295 (/ISO) Q9WU56 (/ISO) |
|
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
|
2 | Q4KM92 (/ISS) Q4KM92 (/ISS) |
|
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
1 | Q9WU56 (/ISO) |
|
Steroid receptor RNA activator RNA binding GO:0002153
Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.
|
1 | Q9WU56 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9WU56 (/IPI) |
|
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
|
1 | Q9WU56 (/IDA) |
|
TRNA pseudouridine synthase activity GO:0106029
Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
|
1 | Q9WU56 (/IDA) |
|
SnRNA pseudouridine synthase activity GO:0106032
Catalysis of the reaction: an snRNA uridine = an snRNA pseudouridine. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
|
1 | O94396 (/EXP) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
TRNA pseudouridine synthesis GO:0031119
The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.
|
8 | O94396 (/IDA) Q12211 (/IDA) Q12211 (/IDA) Q12211 (/IDA) Q12211 (/IDA) Q12211 (/IDA) Q12211 (/IDA) Q9WU56 (/IDA) |
|
TRNA modification GO:0006400
The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
|
6 | Q12211 (/TAS) Q12211 (/TAS) Q12211 (/TAS) Q12211 (/TAS) Q12211 (/TAS) Q12211 (/TAS) |
|
SnRNA pseudouridine synthesis GO:0031120
The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.
|
6 | Q12211 (/IMP) Q12211 (/IMP) Q12211 (/IMP) Q12211 (/IMP) Q12211 (/IMP) Q12211 (/IMP) |
|
MRNA pseudouridine synthesis GO:1990481
The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.
|
6 | Q12211 (/IMP) Q12211 (/IMP) Q12211 (/IMP) Q12211 (/IMP) Q12211 (/IMP) Q12211 (/IMP) |
|
Mitochondrial tRNA pseudouridine synthesis GO:0070902
The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule.
|
2 | Q9Y606 (/TAS) Q9Y606 (/TAS) |
|
TRNA pseudouridine synthesis GO:0031119
The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.
|
1 | O94295 (/ISO) |
|
SnRNA pseudouridine synthesis GO:0031120
The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.
|
1 | O94396 (/EXP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q9WU56 (/IDA) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | E5KMT5 (/IDA) E5KMT5 (/IDA) E5KMT6 (/IDA) F5H1S9 (/IDA) G8JLB3 (/IDA) Q9WU56 (/IDA) Q9Y606 (/IDA) Q9Y606 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
7 | E5KMT5 (/IDA) E5KMT5 (/IDA) E5KMT6 (/IDA) F5H1S9 (/IDA) G8JLB3 (/IDA) Q9Y606 (/IDA) Q9Y606 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | Q12211 (/IPI) Q12211 (/IPI) Q12211 (/IPI) Q12211 (/IPI) Q12211 (/IPI) Q12211 (/IPI) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
6 | Q12211 (/TAS) Q12211 (/TAS) Q12211 (/TAS) Q12211 (/TAS) Q12211 (/TAS) Q12211 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | O94295 (/HDA) O94396 (/HDA) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
2 | Q9Y606 (/TAS) Q9Y606 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O94396 (/IGI) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9WU56 (/ISO) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | Q9WU56 (/IDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q9WU56 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9WU56 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9LN29 (/IDA) |