The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 137: pre-mRNA-splicing factor RBM22

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
U6 snRNA binding GO:0017070
Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA).
92 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS)
(82 more)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
92 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS)
(82 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
42 Q9NW64 (/HDA) Q9NW64 (/HDA) Q9NW64 (/HDA) Q9NW64 (/HDA) Q9NW64 (/HDA) Q9NW64 (/HDA) Q9NW64 (/HDA) Q9NW64 (/HDA) Q9NW64 (/HDA) Q9NW64 (/HDA)
(32 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
42 Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI)
(32 more)
U6 snRNA binding GO:0017070
Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA).
42 Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(32 more)
U6 snRNA binding GO:0017070
Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA).
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
42 Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(32 more)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
42 Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI) Q9NW64 (/IPI)
(32 more)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q95RB1 (/ISS)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of RNA splicing GO:0033120
Any process that activates or increases the frequency, rate or extent of RNA splicing.
92 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS)
(82 more)
MRNA cis splicing, via spliceosome GO:0045292
The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
92 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS)
(82 more)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
88 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS)
(78 more)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
87 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS)
(77 more)
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
87 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS)
(77 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
43 Q95RB1 (/IC) Q9NW64 (/IC) Q9NW64 (/IC) Q9NW64 (/IC) Q9NW64 (/IC) Q9NW64 (/IC) Q9NW64 (/IC) Q9NW64 (/IC) Q9NW64 (/IC) Q9NW64 (/IC)
(33 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
42 Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS)
(32 more)
Positive regulation of RNA splicing GO:0033120
Any process that activates or increases the frequency, rate or extent of RNA splicing.
42 Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(32 more)
Positive regulation of RNA splicing GO:0033120
Any process that activates or increases the frequency, rate or extent of RNA splicing.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
42 Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(32 more)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
42 Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(32 more)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
MRNA cis splicing, via spliceosome GO:0045292
The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
42 Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(32 more)
MRNA cis splicing, via spliceosome GO:0045292
The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
42 Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(32 more)
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 Q95RB1 (/HMP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
1 Q6NZZ9 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
92 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS)
(82 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
91 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS) Q4R4J1 (/ISS)
(81 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
43 Q6NZZ9 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(33 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
42 Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS) Q9NW64 (/TAS)
(32 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
42 Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(32 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
U2-type catalytic step 2 spliceosome GO:0071007
A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
42 Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(32 more)
U2-type catalytic step 2 spliceosome GO:0071007
A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
42 Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA) Q9NW64 (/IDA)
(32 more)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
42 Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO) Q8BHS3 (/ISO)
(32 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q95RB1 (/IC)
Precatalytic spliceosome GO:0071011
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
1 Q95RB1 (/HDA)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
1 Q95RB1 (/HDA)