The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 38: Tyrosine-protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 33 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P43405 (/IPI) P43405 (/IPI) P48025 (/IPI) P48025 (/IPI) Q64725 (/IPI)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
4 P43405 (/IDA) P43405 (/IDA) P48025 (/IDA) P48025 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
3 P43405 (/IDA) P43405 (/IDA) Q64725 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
3 P43405 (/EXP) P43405 (/EXP) Q64725 (/EXP)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
3 F1N9Y5 (/IMP) P48025 (/IMP) P48025 (/IMP)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
3 P43405 (/TAS) P43405 (/TAS) Q00655 (/TAS)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
2 P43405 (/IMP) P43405 (/IMP)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
2 P43405 (/IPI) P43405 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
2 P48025 (/ISO) P48025 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 P48025 (/ISO) P48025 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 P43405 (/NAS) P43405 (/NAS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 P43405 (/IDA) P43405 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 P48025 (/ISO) P48025 (/ISO)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 P48025 (/IDA) P48025 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 P48025 (/ISO) P48025 (/ISO)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 P43405 (/NAS) P43405 (/NAS)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 P43405 (/TAS) P43405 (/TAS)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
2 P48025 (/ISO) P48025 (/ISO)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
2 Q00655 (/ISS) Q64725 (/ISS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 P43405 (/IPI) P43405 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 P48025 (/ISO) P48025 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 P48025 (/IDA) P48025 (/IDA)
Interleukin-15 receptor binding GO:0016170
Interacting selectively and non-covalently with the interleukin-15 receptor.
2 P43405 (/IPI) P43405 (/IPI)
Interleukin-15 receptor binding GO:0016170
Interacting selectively and non-covalently with the interleukin-15 receptor.
2 P48025 (/ISO) P48025 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P48025 (/IPI) P48025 (/IPI)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
2 P48025 (/IPI) P48025 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 P48025 (/ISO) P48025 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 P48025 (/ISO) P48025 (/ISO)
Toll-like receptor binding GO:0035325
Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
2 P48025 (/IPI) P48025 (/IPI)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
2 P48025 (/IDA) P48025 (/IDA)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
1 F1N9Y5 (/IMP)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q64725 (/IDA)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 Q64725 (/IPI)

There are 127 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
6 P43405 (/ISS) P43405 (/ISS) P48025 (/ISS) P48025 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 P43405 (/ISS) P43405 (/ISS) P48025 (/ISS) P48025 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Lymph vessel development GO:0001945
The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Macrophage activation involved in immune response GO:0002281
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Neutrophil activation involved in immune response GO:0002283
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Leukocyte activation involved in immune response GO:0002366
A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Serotonin secretion by platelet GO:0002554
The regulated release of serotonin by a platelet or group of platelets.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
5 F1N9Y5 (/ISS) P48025 (/ISS) P48025 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of platelet activation GO:0010543
Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
5 F1N9Y5 (/ISS) P48025 (/ISS) P48025 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of superoxide anion generation GO:0032928
Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Positive regulation of cell adhesion mediated by integrin GO:0033630
Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of neutrophil degranulation GO:0043313
Any process that modulates the frequency, rate, or extent of neutrophil degranulation.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of phagocytosis GO:0050764
Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Cellular response to molecule of fungal origin GO:0071226
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of arachidonic acid secretion GO:0090237
Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of platelet aggregation GO:0090330
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
5 D3ZH44 (/ISS) G3V7N4 (/ISS) P43405 (/ISS) P43405 (/ISS) Q64725 (/ISS)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
4 P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
4 P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Interleukin-3-mediated signaling pathway GO:0038156
A series of molecular signals initiated by the binding of interleukin-3 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Positive regulation of B cell differentiation GO:0045579
Any process that activates or increases the frequency, rate or extent of B cell differentiation.
4 P43405 (/IMP) P43405 (/IMP) P48025 (/IMP) P48025 (/IMP)
B cell receptor signaling pathway GO:0050853
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
4 P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
4 P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
3 E9QFU7 (/IGI) F1QFN4 (/IGI) Q910A2 (/IGI)
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
3 E9QFU7 (/IMP) F1QFN4 (/IMP) Q910A2 (/IMP)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
3 F1N9Y5 (/IMP) P48025 (/IMP) P48025 (/IMP)
Positive regulation of mast cell degranulation GO:0043306
Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
3 P48025 (/IMP) P48025 (/IMP) Q64725 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
3 P48025 (/IDA) P48025 (/IDA) Q64725 (/IDA)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
3 E9QFU7 (/IGI) F1QFN4 (/IGI) Q910A2 (/IGI)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
3 E9QFU7 (/IMP) F1QFN4 (/IMP) Q910A2 (/IMP)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
2 P48025 (/IDA) P48025 (/IDA)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
2 P48025 (/IMP) P48025 (/IMP)
Serotonin secretion GO:0001820
The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.
2 P48025 (/IMP) P48025 (/IMP)
Lymph vessel development GO:0001945
The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
2 P48025 (/IMP) P48025 (/IMP)
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
2 P43405 (/TAS) P43405 (/TAS)
Macrophage activation involved in immune response GO:0002281
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
2 P48025 (/IMP) P48025 (/IMP)
Neutrophil activation involved in immune response GO:0002283
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
2 P48025 (/IMP) P48025 (/IMP)
Leukocyte activation involved in immune response GO:0002366
A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
2 P48025 (/IMP) P48025 (/IMP)
Serotonin secretion by platelet GO:0002554
The regulated release of serotonin by a platelet or group of platelets.
2 P48025 (/IMP) P48025 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P43405 (/IDA) P43405 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P48025 (/ISO) P48025 (/ISO)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
2 P43405 (/IMP) P43405 (/IMP)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
2 P48025 (/ISO) P48025 (/ISO)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
2 P43405 (/IDA) P43405 (/IDA)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
2 P48025 (/ISO) P48025 (/ISO)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P48025 (/IDA) P48025 (/IDA)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P48025 (/IMP) P48025 (/IMP)
Enzyme linked receptor protein signaling pathway GO:0007167
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P48025 (/IDA) P48025 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P48025 (/TAS) P48025 (/TAS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P48025 (/IMP) P48025 (/IMP)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P43405 (/NAS) P43405 (/NAS)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
2 P48025 (/IMP) P48025 (/IMP)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
2 P43405 (/TAS) P43405 (/TAS)
Regulation of platelet activation GO:0010543
Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
2 P48025 (/IMP) P48025 (/IMP)
Regulation of tumor necrosis factor-mediated signaling pathway GO:0010803
Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2 P43405 (/IMP) P43405 (/IMP)
Regulation of tumor necrosis factor-mediated signaling pathway GO:0010803
Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2 P48025 (/ISO) P48025 (/ISO)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
2 P48025 (/IDA) P48025 (/IDA)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
2 P48025 (/IDA) P48025 (/IDA)
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
2 P48025 (/IMP) P48025 (/IMP)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
2 P43405 (/TAS) P43405 (/TAS)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
2 P43405 (/IDA) P43405 (/IDA)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
2 P48025 (/ISO) P48025 (/ISO)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
2 P43405 (/IMP) P43405 (/IMP)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
2 P48025 (/ISO) P48025 (/ISO)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
2 P48025 (/IDA) P48025 (/IDA)
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
2 P48025 (/IMP) P48025 (/IMP)
Regulation of superoxide anion generation GO:0032928
Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
2 P43405 (/IMP) P43405 (/IMP)
Positive regulation of cell adhesion mediated by integrin GO:0033630
Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
2 P48025 (/IMP) P48025 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 P48025 (/IDA) P48025 (/IDA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 P48025 (/IMP) P48025 (/IMP)
Collagen-activated tyrosine kinase receptor signaling pathway GO:0038063
A series of molecular signals initiated by the binding of collagen to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P48025 (/IMP) P48025 (/IMP)
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
2 P43405 (/TAS) P43405 (/TAS)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
2 P43405 (/TAS) P43405 (/TAS)
Interleukin-2-mediated signaling pathway GO:0038110
A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P43405 (/TAS) P43405 (/TAS)
Interleukin-3-mediated signaling pathway GO:0038156
A series of molecular signals initiated by the binding of interleukin-3 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of tumor necrosis factor biosynthetic process GO:0042535
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
2 P43405 (/IMP) P43405 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
2 P43405 (/IMP) P43405 (/IMP)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
2 P48025 (/ISO) P48025 (/ISO)
Positive regulation of mast cell degranulation GO:0043306
Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
2 P48025 (/ISO) P48025 (/ISO)
Regulation of neutrophil degranulation GO:0043313
Any process that modulates the frequency, rate, or extent of neutrophil degranulation.
2 P48025 (/IMP) P48025 (/IMP)
Beta selection GO:0043366
The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell.
2 P48025 (/IGI) P48025 (/IGI)
Positive regulation of interleukin-10 biosynthetic process GO:0045082
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10.
2 P43405 (/IMP) P43405 (/IMP)
Positive regulation of interleukin-12 biosynthetic process GO:0045084
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.
2 P43405 (/IMP) P43405 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of interleukin-3 biosynthetic process GO:0045401
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of interleukin-6 biosynthetic process GO:0045410
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.
2 P43405 (/IMP) P43405 (/IMP)
Positive regulation of interleukin-8 biosynthetic process GO:0045416
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.
2 P43405 (/IMP) P43405 (/IMP)
Positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process GO:0045425
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of B cell differentiation GO:0045579
Any process that activates or increases the frequency, rate or extent of B cell differentiation.
2 P48025 (/ISO) P48025 (/ISO)
Positive regulation of gamma-delta T cell differentiation GO:0045588
Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of alpha-beta T cell differentiation GO:0046638
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.
2 P48025 (/IGI) P48025 (/IGI)
Positive regulation of alpha-beta T cell proliferation GO:0046641
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.
2 P48025 (/IGI) P48025 (/IGI)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 P48025 (/ISO) P48025 (/ISO)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
2 P48025 (/IGI) P48025 (/IGI)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 P48025 (/IMP) P48025 (/IMP)
Regulation of phagocytosis GO:0050764
Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
2 P48025 (/IMP) P48025 (/IMP)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
2 P48025 (/ISO) P48025 (/ISO)
Positive regulation of calcium-mediated signaling GO:0050850
Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
2 P48025 (/IMP) P48025 (/IMP)
B cell receptor signaling pathway GO:0050853
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
2 P48025 (/IDA) P48025 (/IDA)
Regulation of DNA-binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 P43405 (/IMP) P43405 (/IMP)
Regulation of DNA-binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 P48025 (/ISO) P48025 (/ISO)
Positive regulation of killing of cells of other organism GO:0051712
Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism.
2 P43405 (/IMP) P43405 (/IMP)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P48025 (/IMP) P48025 (/IMP)
Cellular response to molecule of fungal origin GO:0071226
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
2 P48025 (/IMP) P48025 (/IMP)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
2 P48025 (/IDA) P48025 (/IDA)
Positive regulation of monocyte chemotactic protein-1 production GO:0071639
Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1.
2 P43405 (/IMP) P43405 (/IMP)
Regulation of arachidonic acid secretion GO:0090237
Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.
2 P48025 (/IMP) P48025 (/IMP)
Regulation of platelet aggregation GO:0090330
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
2 P48025 (/IMP) P48025 (/IMP)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
2 P48025 (/IMP) P48025 (/IMP)
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
1 F1N9Y5 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 F1N9Y5 (/IMP)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
1 Q64725 (/IDA)
B cell receptor signaling pathway GO:0050853
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
1 F1N9Y5 (/IMP)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 F1N9Y5 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P43405 (/TAS) P43405 (/TAS) P48025 (/TAS) P48025 (/TAS) Q00655 (/TAS) Q64725 (/TAS)
Early phagosome GO:0032009
A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
5 F1N9Y5 (/ISS) P43405 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
4 P43405 (/IDA) P43405 (/IDA) P48025 (/IDA) P48025 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 F1N9Y5 (/TAS) P43405 (/TAS) P43405 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P43405 (/IDA) P43405 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P48025 (/ISO) P48025 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P43405 (/IDA) P43405 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P48025 (/ISO) P48025 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P43405 (/IC) P43405 (/IC)
B cell receptor complex GO:0019815
An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
2 P48025 (/IDA) P48025 (/IDA)
Early phagosome GO:0032009
A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
2 P48025 (/IDA) P48025 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P48025 (/ISO) P48025 (/ISO)
T cell receptor complex GO:0042101
A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2 P43405 (/IDA) P43405 (/IDA)
T cell receptor complex GO:0042101
A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
2 P48025 (/ISO) P48025 (/ISO)