The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 21: Putative SH2 domain-containing adapter protein F

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
3 Q15464 (/TAS) Q15464 (/TAS) Q6PD21 (/TAS)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
2 Q15464 (/IPI) Q15464 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q15464 (/IPI) Q15464 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
1 Q6PD21 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q6PD21 (/IDA)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 Q15464 (/TAS) Q15464 (/TAS)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q15464 (/TAS) Q15464 (/TAS)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
1 Q6PD21 (/IMP)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 Q6PD21 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q6PD21 (/IMP)
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
1 Q6PD21 (/IDA)
Positive regulation of T-helper cell differentiation GO:0045624
Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation.
1 Q6PD21 (/IMP)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
1 Q6PD21 (/IMP)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
1 Q6PD21 (/IGI)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
1 Q6PD21 (/IMP)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
1 Q6PD21 (/IMP)
Hematopoietic stem cell proliferation GO:0071425
The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.
1 Q6PD21 (/IMP)
Negative regulation of oocyte maturation GO:1900194
Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.
1 Q6PD21 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q15464 (/IDA) Q15464 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q15464 (/IDA) Q15464 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q15464 (/TAS) Q15464 (/TAS)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
2 Q15464 (/IDA) Q15464 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q6PD21 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6PD21 (/ISO)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
1 Q6PD21 (/ISO)