The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 105: Transcription elongation factor SPT6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription antitermination factor activity, DNA binding GO:0001073
Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein.
2 P23615 (/IDA) P23615 (/IDA)
Transcription antitermination factor activity, DNA binding GO:0001073
Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein.
2 P23615 (/IGI) P23615 (/IGI)
Transcription antitermination factor activity, DNA binding GO:0001073
Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein.
2 P23615 (/IMP) P23615 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P23615 (/IPI) P23615 (/IPI)
Nucleosome binding GO:0031491
Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
2 P23615 (/IDA) P23615 (/IDA)
Nucleosome binding GO:0031491
Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
2 P23615 (/IMP) P23615 (/IMP)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
2 P23615 (/IDA) P23615 (/IDA)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P23615 (/IMP) P23615 (/IMP)
Regulation of histone H3-K36 methylation GO:0000414
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
2 P23615 (/IDA) P23615 (/IDA)
Regulation of histone H3-K36 methylation GO:0000414
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
2 P23615 (/IMP) P23615 (/IMP)
Carbon catabolite repression of transcription from RNA polymerase II promoter by glucose GO:0000433
A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.
2 P23615 (/IMP) P23615 (/IMP)
Regulation of transcriptional start site selection at RNA polymerase II promoter GO:0001178
Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
2 P23615 (/IMP) P23615 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
2 P23615 (/IMP) P23615 (/IMP)
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
2 P23615 (/IDA) P23615 (/IDA)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
2 P23615 (/IGI) P23615 (/IGI)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
2 P23615 (/IMP) P23615 (/IMP)
Poly(A)+ mRNA export from nucleus GO:0016973
The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
2 P23615 (/IMP) P23615 (/IMP)
Regulation of mRNA 3'-end processing GO:0031440
Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.
2 P23615 (/IGI) P23615 (/IGI)
Regulation of mRNA 3'-end processing GO:0031440
Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.
2 P23615 (/IMP) P23615 (/IMP)
Transcription antitermination GO:0031564
Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s).
2 P23615 (/IGI) P23615 (/IGI)
Transcription antitermination GO:0031564
Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s).
2 P23615 (/IMP) P23615 (/IMP)
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
2 P23615 (/IDA) P23615 (/IDA)
Nucleosome organization GO:0034728
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes.
2 P23615 (/IMP) P23615 (/IMP)
Regulation of transcription from RNA polymerase II promoter in response to stress GO:0043618
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
2 P23615 (/IMP) P23615 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P23615 (/IMP) P23615 (/IMP)
Regulation of nucleosome density GO:0060303
Any process that modulates the number of nucleosomes in a given region of a chromosome.
2 P23615 (/IMP) P23615 (/IMP)
Chromatin maintenance GO:0070827
The chromatin organization process that preserves chromatin in a stable functional or structural state.
2 P23615 (/IMP) P23615 (/IMP)
Positive regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071931
Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle.
2 P23615 (/IMP) P23615 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P23615 (/IDA) P23615 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P23615 (/HDA) P23615 (/HDA)
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
2 P23615 (/IDA) P23615 (/IDA)