The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Erythroid Transcription Factor GATA-1, subunit A
".
FunFam 12: Hepatocyte nuclear factor 4, alpha
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 52 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | P41235 (/ISA) P41235 (/ISA) Q14541 (/ISA) Q14541 (/ISA) Q14541 (/ISA) Q14541 (/ISA) Q14541 (/ISA) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | P41235 (/ISM) P41235 (/ISM) Q14541 (/ISM) Q14541 (/ISM) Q14541 (/ISM) Q14541 (/ISM) Q14541 (/ISM) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | P41235 (/NAS) P41235 (/NAS) Q14541 (/NAS) Q14541 (/NAS) Q14541 (/NAS) Q14541 (/NAS) Q14541 (/NAS) |
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
6 | P49698 (/IDA) Q14541 (/IDA) Q14541 (/IDA) Q14541 (/IDA) Q14541 (/IDA) Q14541 (/IDA) |
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
5 | Q14541 (/IC) Q14541 (/IC) Q14541 (/IC) Q14541 (/IC) Q14541 (/IC) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
5 | F1NZ15 (/IDA) P41235 (/IDA) P41235 (/IDA) P49698 (/IDA) Q5ILH0 (/IDA) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
5 | Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
4 | A8E5K2 (/IGI) E9QFX6 (/IGI) Q6PHH5 (/IGI) Q8AXB6 (/IGI) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P22449 (/IPI) P41235 (/IPI) P41235 (/IPI) P49698 (/IPI) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
3 | P41235 (/IDA) P41235 (/IDA) P49698 (/IDA) |
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
3 | P41235 (/IDA) P41235 (/IDA) P49698 (/IDA) |
Core promoter sequence-specific DNA binding GO:0001046
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
|
2 | F1NZ15 (/IDA) Q5ILH0 (/IDA) |
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
2 | P41235 (/ISS) P41235 (/ISS) |
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P22449 (/IDA) P49698 (/IDA) |
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P41235 (/ISS) P41235 (/ISS) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P41235 (/IDA) P41235 (/IDA) |
Fatty acid binding GO:0005504
Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
|
2 | P41235 (/IDA) P41235 (/IDA) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P41235 (/IDA) P41235 (/IDA) |
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
2 | F1NZ15 (/IDA) Q5ILH0 (/IDA) |
Fatty-acyl-CoA binding GO:0000062
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
|
1 | P22449 (/IPI) |
Fatty-acyl-CoA binding GO:0000062
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
|
1 | P49698 (/ISO) |
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q9WUU6 (/ISO) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P49698 (/IDA) |
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | P22449 (/IDA) |
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | P49698 (/ISO) |
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
1 | P49698 (/IPI) |
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P49698 (/ISO) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | P49698 (/ISO) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | P22449 (/IMP) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | P49698 (/ISO) |
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
|
1 | P49866 (/NAS) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P49698 (/ISO) |
Fatty acid binding GO:0005504
Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
|
1 | P22449 (/IPI) |
Fatty acid binding GO:0005504
Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
|
1 | P49698 (/ISO) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | P22449 (/IPI) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | P49698 (/ISO) |
Palmitoyl-CoA hydrolase activity GO:0016290
Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.
|
1 | P22449 (/IDA) |
Palmitoyl-CoA hydrolase activity GO:0016290
Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.
|
1 | P49698 (/ISO) |
Long-chain fatty acyl-CoA binding GO:0036042
Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
|
1 | P22449 (/IDA) |
Long-chain fatty acyl-CoA binding GO:0036042
Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
|
1 | P49698 (/ISO) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P22449 (/IMP) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P49698 (/ISO) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | P49698 (/IDA) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | P22449 (/IMP) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | P49698 (/ISO) |
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
1 | P49698 (/ISO) |
Arachidonic acid binding GO:0050544
Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
|
1 | P22449 (/IDA) |
Arachidonic acid binding GO:0050544
Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
|
1 | P49698 (/ISO) |
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
|
1 | P22449 (/IPI) |
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
|
1 | P49698 (/ISO) |
Stearic acid binding GO:0070540
Interacting selectively and non-covalently with stearic acid, the 18-carbon saturated fatty acid octadecanoic acid.
|
1 | P22449 (/IDA) |
Stearic acid binding GO:0070540
Interacting selectively and non-covalently with stearic acid, the 18-carbon saturated fatty acid octadecanoic acid.
|
1 | P49698 (/ISO) |
There are 98 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
9 | P22449 (/IDA) P41235 (/IDA) P41235 (/IDA) P49698 (/IDA) Q14541 (/IDA) Q14541 (/IDA) Q14541 (/IDA) Q14541 (/IDA) Q14541 (/IDA) |
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
7 | P41235 (/TAS) P41235 (/TAS) Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | P22449 (/IDA) P41235 (/IDA) P41235 (/IDA) P49698 (/IDA) Q9WUU6 (/IDA) |
Type B pancreatic cell development GO:0003323
The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
|
4 | A8E5K2 (/IMP) E9QFX6 (/IMP) Q6PHH5 (/IMP) Q8AXB6 (/IMP) |
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
|
4 | A8E5K2 (/IMP) E9QFX6 (/IMP) Q6PHH5 (/IMP) Q8AXB6 (/IMP) |
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
4 | A8E5K2 (/IMP) E9QFX6 (/IMP) Q6PHH5 (/IMP) Q8AXB6 (/IMP) |
Pancreas regeneration GO:1990798
The regrowth of a destroyed pancreas.
|
4 | A8E5K2 (/IMP) E9QFX6 (/IMP) Q6PHH5 (/IMP) Q8AXB6 (/IMP) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | P41235 (/IMP) P41235 (/IMP) P49698 (/IMP) |
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
3 | P41235 (/IMP) P41235 (/IMP) P49698 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | P41235 (/IMP) P41235 (/IMP) P49698 (/IMP) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P41235 (/IDA) P41235 (/IDA) |
Ornithine metabolic process GO:0006591
The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.
|
2 | P41235 (/IMP) P41235 (/IMP) |
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
|
2 | P41235 (/IMP) P41235 (/IMP) |
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
|
2 | P41235 (/IDA) P41235 (/IDA) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | P41235 (/IMP) P41235 (/IMP) |
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
2 | P41235 (/ISS) P41235 (/ISS) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | F1NZ15 (/IDA) Q5ILH0 (/IDA) |
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
2 | P41235 (/IDA) P41235 (/IDA) |
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
2 | P41235 (/IMP) P41235 (/IMP) |
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
2 | P49698 (/TAS) Q9WUU6 (/TAS) |
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
2 | P49698 (/IMP) P49866 (/IMP) |
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
2 | P41235 (/ISS) P41235 (/ISS) |
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
2 | P41235 (/ISS) P41235 (/ISS) |
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
2 | P22449 (/ISS) Q91766 (/ISS) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P41235 (/IDA) P41235 (/IDA) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P22449 (/ISS) P49698 (/ISS) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P49698 (/ISO) Q9WUU6 (/ISO) |
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
|
2 | P41235 (/ISS) P41235 (/ISS) |
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
|
2 | P41235 (/IMP) P41235 (/IMP) |
Phospholipid homeostasis GO:0055091
Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
|
2 | P41235 (/ISS) P41235 (/ISS) |
Triglyceride homeostasis GO:0070328
Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
|
2 | P41235 (/ISS) P41235 (/ISS) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P49698 (/IMP) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P49698 (/ISO) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P49698 (/IGI) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P49698 (/ISO) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P49866 (/ISS) |
Ornithine metabolic process GO:0006591
The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.
|
1 | P49698 (/ISO) |
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
|
1 | P49698 (/IMP) |
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
|
1 | P22449 (/IDA) |
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
|
1 | P49698 (/ISO) |
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
|
1 | P49698 (/ISO) |
Establishment of tissue polarity GO:0007164
Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.
|
1 | P22449 (/IDA) |
Establishment of tissue polarity GO:0007164
Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.
|
1 | P49698 (/ISO) |
Sex differentiation GO:0007548
The establishment of the sex of an organism by physical differentiation.
|
1 | P49698 (/IMP) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | P22449 (/IEP) |
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
|
1 | P49698 (/ISO) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P22449 (/IDA) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P49698 (/ISO) |
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
1 | P22449 (/IDA) |
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
1 | P49698 (/IMP) |
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
1 | P49698 (/ISO) |
Regulation of gastrulation GO:0010470
Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.
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1 | P49698 (/IMP) |
Lipid catabolic process GO:0016042
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
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1 | P49866 (/IDA) |
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
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1 | P49698 (/ISO) |
Signal transduction involved in regulation of gene expression GO:0023019
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
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1 | P49698 (/IDA) |
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
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1 | P22449 (/IMP) |
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
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1 | P49698 (/ISO) |
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
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1 | P49698 (/ISO) |
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
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1 | P22449 (/IDA) |
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
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1 | P49698 (/ISO) |
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
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1 | P22449 (/IEP) |
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
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1 | P22449 (/IEP) |
Regulation of microvillus assembly GO:0032534
A process that modulates the formation of a microvillus.
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1 | P22449 (/IMP) |
Regulation of microvillus assembly GO:0032534
A process that modulates the formation of a microvillus.
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1 | P49698 (/ISO) |
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
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1 | P49866 (/IMP) |
Lipid oxidation GO:0034440
The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
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1 | P49866 (/IDA) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
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1 | P22449 (/IEP) |
Negative regulation of tyrosine phosphorylation of STAT protein GO:0042532
Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
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1 | P22449 (/IDA) |
Negative regulation of tyrosine phosphorylation of STAT protein GO:0042532
Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
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1 | P49698 (/ISO) |
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
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1 | P49698 (/IMP) |
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
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1 | P49698 (/ISO) |
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
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1 | P22449 (/IDA) |
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
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1 | P49698 (/ISO) |
Cell-cell junction organization GO:0045216
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.
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1 | P22449 (/IDA) |
Cell-cell junction organization GO:0045216
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.
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1 | P49698 (/ISO) |
Positive regulation of gluconeogenesis GO:0045722
Any process that activates or increases the frequency, rate or extent of gluconeogenesis.
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1 | P22449 (/IMP) |
Positive regulation of gluconeogenesis GO:0045722
Any process that activates or increases the frequency, rate or extent of gluconeogenesis.
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1 | P49698 (/ISO) |
Positive regulation of fatty acid biosynthetic process GO:0045723
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
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1 | P22449 (/IMP) |
Positive regulation of fatty acid biosynthetic process GO:0045723
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
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1 | P49698 (/ISO) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
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1 | P49698 (/ISO) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
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1 | P49698 (/ISO) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
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1 | Q91766 (/ISS) |
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
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1 | P22449 (/IDA) |
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
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1 | P49698 (/ISO) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
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1 | P49698 (/IGI) |
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
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1 | P49698 (/IMP) |
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
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1 | P22449 (/IEP) |
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
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1 | P49698 (/ISO) |
Phospholipid homeostasis GO:0055091
Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
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1 | P49698 (/IMP) |
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
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1 | P49698 (/IDA) |
Triglyceride homeostasis GO:0070328
Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
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1 | P49698 (/IMP) |
Hepatocyte differentiation GO:0070365
The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.
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1 | P22449 (/IEP) |
Heterochromatin organization involved in chromatin silencing GO:0070868
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing.
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1 | P49866 (/IMP) |
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
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1 | P22449 (/IEP) |
Response to dexamethasone GO:0071548
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
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1 | P22449 (/IEP) |
Negative regulation of activation of Janus kinase activity GO:1902569
Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK (Janus Activated Kinase) kinase activity.
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1 | P22449 (/IDA) |
Negative regulation of activation of Janus kinase activity GO:1902569
Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK (Janus Activated Kinase) kinase activity.
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1 | P49698 (/ISO) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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7 | F1NZ15 (/IDA) P22449 (/IDA) P41235 (/IDA) P41235 (/IDA) P49698 (/IDA) P49866 (/IDA) Q5ILH0 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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7 | A0A087WXV4 (/IDA) F1D8S2 (/IDA) F1D8T0 (/IDA) F1D8T1 (/IDA) F1D8T1 (/IDA) P41235 (/IDA) P41235 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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7 | P41235 (/TAS) P41235 (/TAS) Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) Q14541 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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3 | P22449 (/IDA) P41235 (/IDA) P41235 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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2 | P49698 (/TAS) Q9WUU6 (/TAS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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1 | P49698 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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1 | P49698 (/ISO) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
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1 | P49698 (/ISO) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
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1 | Q9WUU6 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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1 | P49698 (/ISO) |