The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Beta Polymerase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: poly(A) RNA polymerase GLD2 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Polynucleotide adenylyltransferase activity GO:0004652
Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
10 Q2HJ44 (/ISS) Q2HJ44 (/ISS) Q503I9 (/ISS) Q5U315 (/ISS) Q641A1 (/ISS) Q641A1 (/ISS) Q9VD44 (/ISS) Q9VD44 (/ISS) Q9VYS4 (/ISS) Q9VYS4 (/ISS)
5'-3' RNA polymerase activity GO:0034062
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end.
10 Q0VFA3 (/ISS) Q2HJ44 (/ISS) Q2HJ44 (/ISS) Q503I9 (/ISS) Q5U315 (/ISS) Q641A1 (/ISS) Q641A1 (/ISS) Q6DFA8 (/ISS) Q6DFA8 (/ISS) Q91YI6 (/ISS)
Adenylyltransferase activity GO:0070566
Catalysis of the transfer of an adenylyl group to an acceptor.
10 Q0VFA3 (/ISS) Q2HJ44 (/ISS) Q2HJ44 (/ISS) Q503I9 (/ISS) Q5U315 (/ISS) Q641A1 (/ISS) Q641A1 (/ISS) Q6DFA8 (/ISS) Q6DFA8 (/ISS) Q91YI6 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 Q641A1 (/IPI) Q641A1 (/IPI) Q6PIY7 (/IPI) Q6PIY7 (/IPI) Q91YI6 (/IPI) Q9VD44 (/IPI) Q9VD44 (/IPI) Q9VYS4 (/IPI) Q9VYS4 (/IPI)
Polynucleotide adenylyltransferase activity GO:0004652
Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
6 Q6PIY7 (/IDA) Q6PIY7 (/IDA) Q9VD44 (/IDA) Q9VD44 (/IDA) Q9VYS4 (/IDA) Q9VYS4 (/IDA)
5'-3' RNA polymerase activity GO:0034062
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end.
2 Q6PIY7 (/IDA) Q6PIY7 (/IDA)
Adenylyltransferase activity GO:0070566
Catalysis of the transfer of an adenylyl group to an acceptor.
2 Q6PIY7 (/IDA) Q6PIY7 (/IDA)
Polynucleotide adenylyltransferase activity GO:0004652
Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
1 Q91YI6 (/ISO)
5'-3' RNA polymerase activity GO:0034062
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end.
1 Q91YI6 (/ISO)
Adenylyltransferase activity GO:0070566
Catalysis of the transfer of an adenylyl group to an acceptor.
1 Q91YI6 (/ISO)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA stabilization GO:0043489
Prevention of degradation of RNA molecules.
10 Q0VFA3 (/ISS) Q2HJ44 (/ISS) Q2HJ44 (/ISS) Q503I9 (/ISS) Q5U315 (/ISS) Q641A1 (/ISS) Q641A1 (/ISS) Q6DFA8 (/ISS) Q6DFA8 (/ISS) Q91YI6 (/ISS)
RNA polyadenylation GO:0043631
The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.
10 Q2HJ44 (/ISS) Q2HJ44 (/ISS) Q503I9 (/ISS) Q5U315 (/ISS) Q641A1 (/ISS) Q641A1 (/ISS) Q9VD44 (/ISS) Q9VD44 (/ISS) Q9VYS4 (/ISS) Q9VYS4 (/ISS)
Negative regulation of miRNA catabolic process GO:2000626
Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process.
10 Q0VFA3 (/ISS) Q2HJ44 (/ISS) Q2HJ44 (/ISS) Q503I9 (/ISS) Q5U315 (/ISS) Q641A1 (/ISS) Q641A1 (/ISS) Q6DFA8 (/ISS) Q6DFA8 (/ISS) Q91YI6 (/ISS)
RNA polyadenylation GO:0043631
The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.
4 Q6PIY7 (/IDA) Q6PIY7 (/IDA) Q9VYS4 (/IDA) Q9VYS4 (/IDA)
Histone mRNA catabolic process GO:0071044
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
4 Q2HJ44 (/ISS) Q2HJ44 (/ISS) Q5U315 (/ISS) Q91YI6 (/ISS)
Oocyte maturation GO:0001556
A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
MRNA polyadenylation GO:0006378
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
Positive regulation of antibacterial peptide biosynthetic process GO:0006963
Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
Mitotic spindle organization GO:0007052
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
Spindle assembly involved in female meiosis GO:0007056
The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
Egg activation GO:0007343
The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
Pronuclear fusion GO:0007344
The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
2 Q9VD44 (/IMP) Q9VD44 (/IMP)
Intracellular mRNA localization GO:0008298
Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
Sperm aster formation GO:0035044
Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
Pronuclear migration GO:0035046
The directed movement of the male and female pronuclei towards each other prior to their fusion.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
RNA stabilization GO:0043489
Prevention of degradation of RNA molecules.
2 Q6PIY7 (/IDA) Q6PIY7 (/IDA)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
2 Q9VYS4 (/IMP) Q9VYS4 (/IMP)
Histone mRNA catabolic process GO:0071044
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
2 Q6PIY7 (/IMP) Q6PIY7 (/IMP)
Negative regulation of miRNA catabolic process GO:2000626
Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process.
2 Q6PIY7 (/IDA) Q6PIY7 (/IDA)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
1 Q91YI6 (/IMP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 Q5U315 (/IEP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q5U315 (/IEP)
RNA stabilization GO:0043489
Prevention of degradation of RNA molecules.
1 Q91YI6 (/ISO)
RNA polyadenylation GO:0043631
The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.
1 Q91YI6 (/ISO)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
1 Q5U315 (/IEP)
Histone mRNA catabolic process GO:0071044
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
1 Q91YI6 (/ISO)
Dark adaptation GO:1990603
The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light.
1 Q5U315 (/IEP)
Negative regulation of miRNA catabolic process GO:2000626
Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process.
1 Q91YI6 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q9VD44 (/IDA) Q9VD44 (/IDA) Q9VYS4 (/IDA) Q9VYS4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q5U315 (/IDA) Q91YI6 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q9VD44 (/IDA) Q9VD44 (/IDA)
Nuclear RNA-directed RNA polymerase complex GO:0031380
A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain.
2 Q6PIY7 (/IC) Q6PIY7 (/IC)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 Q9VD44 (/IDA) Q9VD44 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q91YI6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q5U315 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q91YI6 (/ISO)