The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PAS domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 31: Nuclear receptor coactivator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 37 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
3 A0A0G2JZG4 (/IPI) D4A3Q3 (/IPI) P70365 (/IPI)
Nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
3 A0A0G2JZG4 (/IPI) D4A3Q3 (/IPI) Q15788 (/IPI)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
3 A0A0G2JZG4 (/IPI) D4A3Q3 (/IPI) Q15788 (/IPI)
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 A0A0G2JZG4 (/IDA) D4A3Q3 (/IDA)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
2 P70365 (/IDA) Q15788 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P70365 (/IPI) Q15788 (/IPI)
Progesterone receptor binding GO:0033142
Interacting selectively and non-covalently with a progesterone receptor.
2 A0A0G2JZG4 (/IPI) D4A3Q3 (/IPI)
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
2 A0A0G2JZG4 (/IPI) D4A3Q3 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 A0A0G2JZG4 (/IPI) D4A3Q3 (/IPI)
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
2 A0A0G2JZG4 (/IPI) D4A3Q3 (/IPI)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q15788 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q15788 (/ISM)
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P70365 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P70365 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 P70365 (/IDA)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 P70365 (/IMP)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 P70365 (/ISO)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q4PJW2 (/ISS)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q15788 (/NAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 P70365 (/ISO)
Nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
1 P70365 (/ISO)
Aryl hydrocarbon receptor binding GO:0017162
Interacting selectively and non-covalently with an aryl hydrocarbon receptor.
1 Q15788 (/IPI)
Aryl hydrocarbon receptor binding GO:0017162
Interacting selectively and non-covalently with an aryl hydrocarbon receptor.
1 P70365 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q15788 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P70365 (/ISO)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
1 P70365 (/ISO)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
1 Q15788 (/IDA)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
1 P70365 (/ISO)
Progesterone receptor binding GO:0033142
Interacting selectively and non-covalently with a progesterone receptor.
1 P70365 (/ISO)
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
1 Q15788 (/IDA)
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
1 P70365 (/ISO)
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
1 P70365 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P70365 (/ISO)
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
1 P70365 (/ISO)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q15788 (/IPI)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P70365 (/ISO)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 Q15788 (/NAS)

There are 46 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
2 A0A0G2JZG4 (/IEP) D4A3Q3 (/IEP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
2 A0A0G2JZG4 (/IEP) D4A3Q3 (/IEP)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
2 A0A0G2JZG4 (/IEP) D4A3Q3 (/IEP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2 A0A0G2JZG4 (/IEP) D4A3Q3 (/IEP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
2 A0A0G2JZG4 (/IEP) D4A3Q3 (/IEP)
Hypothalamus development GO:0021854
The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.
2 A0A0G2JZG4 (/IEP) D4A3Q3 (/IEP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
2 A0A0G2JZG4 (/IEP) D4A3Q3 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
2 A0A0G2JZG4 (/IEP) D4A3Q3 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
2 A0A0G2JZG4 (/IMP) D4A3Q3 (/IMP)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
2 A0A0G2JZG4 (/IMP) D4A3Q3 (/IMP)
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
2 A0A0G2JZG4 (/IMP) D4A3Q3 (/IMP)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
2 A0A0G2JZG4 (/IMP) D4A3Q3 (/IMP)
Estrous cycle GO:0044849
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
2 A0A0G2JZG4 (/IEP) D4A3Q3 (/IEP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P70365 (/ISS) Q4PJW2 (/ISS)
Positive regulation of female receptivity GO:0045925
Any process that activates or increases the receptiveness of a female to male advances.
2 A0A0G2JZG4 (/IMP) D4A3Q3 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P70365 (/IDA) Q15788 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 A0A0G2JZG4 (/IMP) D4A3Q3 (/IMP)
Male mating behavior GO:0060179
The specific behavior of a male organism that is associated with reproduction.
2 A0A0G2JZG4 (/IMP) D4A3Q3 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter by galactose GO:0000435
Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.
1 Q15788 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter by galactose GO:0000435
Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.
1 P70365 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter by galactose GO:0000435
Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.
1 P70365 (/ISO)
Regulation of thyroid hormone mediated signaling pathway GO:0002155
Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.
1 P70365 (/IGI)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 Q15788 (/IDA)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 P70365 (/ISO)
Bile acid and bile salt transport GO:0015721
The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q15788 (/TAS)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
1 Q15788 (/TAS)
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
1 Q15788 (/NAS)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P70365 (/ISO)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 P70365 (/ISO)
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
1 P70365 (/ISO)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 P70365 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P70365 (/IMP)
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
1 P70365 (/IMP)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 P70365 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q15788 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P70365 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q15788 (/NAS)
Positive regulation of female receptivity GO:0045925
Any process that activates or increases the receptiveness of a female to male advances.
1 P70365 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P70365 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P70365 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q15788 (/NAS)
Male mating behavior GO:0060179
The specific behavior of a male organism that is associated with reproduction.
1 P70365 (/ISO)
Labyrinthine layer morphogenesis GO:0060713
The process in which the labyrinthine layer of the placenta is generated and organized.
1 P70365 (/IGI)
Cellular response to Thyroglobulin triiodothyronine GO:1904017
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus.
1 P70365 (/IGI)
Regulation of cellular response to drug GO:2001038
Any process that modulates the frequency, rate or extent of cellular response to drug.
1 P70365 (/IMP)
Regulation of RNA biosynthetic process GO:2001141
Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
1 P70365 (/IMP)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 A0A0G2JZG4 (/IDA) D4A3Q3 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 B5MCN7 (/IDA) Q15788 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P70365 (/TAS) Q15788 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 A0A0G2JZG4 (/IDA) D4A3Q3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 B5MCN7 (/IDA) Q15788 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 B5MCN7 (/IDA) Q15788 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 A0A0G2JZG4 (/IDA) D4A3Q3 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q15788 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 P70365 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P70365 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P70365 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P70365 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P70365 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P70365 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q15788 (/IMP)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P70365 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P70365 (/ISO)