The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ATPase, nucleotide binding domain

This superfamily comprises structural domains found in several ATPases, including actin PFAM:PF00022, INTERPRO:IPR004000, Hsp70 PFAM:PF00012, INTERPRO:IPR013126, BadF/BadG/BcrA/BcrD PFAM:PF01869, various kinases (acetokinase PFAM:PF00871, INTERPRO:IPR000890, hexokinase PFAM:PF00349, INTERPRO:IPR022672, glucokinase PFAM:PF02685, INTERPRO:IPR003836, glycerol kinase), DnaK INTERPRO:IPR012725, ROK PFAM:PF00480, INTERPRO:IPR000600, PilM PFAM:PF11104, INTERPRO:IPR005883, Fumble PFAM:PF03630. Members of this superfamily have two lobes, one with nucleotide binding activity, and a second one with substrate binding activity. The lobes can be structurally divided into 4 subdomains - 1A, 1B, 2A, 2B (or 1, 2, 3, 4). The ATP binding site in these ATPases is well conserved, and is located at the junction of the two lobes, in a deep cleft. This superfamily entry represents the nucleotide binding domain (NBD) or the first lobe (subdomains 1A and 1B), which exhibits ATPase activity.


GO Diversity

Unique GO annotations
1198 Unique GO terms

EC Diversity

Unique EC annotations
50 Unique EC terms

Species Diversity

Unique species annotations
26500 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 2589
Domain clusters (>95% seq id): 316
Domain clusters (>35% seq id): 166
Unique PDBs: 725
Structural Clusters (5A): 23
Structural Clusters (9A): 12
FunFam Clusters: 1102
Unique EC: 50
Unique GO: 1198
Unique Species: 26500