The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Zinc/RING finger domain, C3HC4 (zinc finger)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 608: E3 ubiquitin-protein ligase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
4 P21461 (/ISS) P21461 (/ISS) P21461 (/ISS) P21461 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P21461 (/IPI) P21461 (/IPI) P21461 (/IPI) P21461 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
4 P21461 (/ISM) P21461 (/ISM) P21461 (/ISM) P21461 (/ISM)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 P21461 (/IPI) P21461 (/IPI) P21461 (/IPI) P21461 (/IPI)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
6 P29304 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) Q8I147 (/ISS)
Sensory organ development GO:0007423
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
6 P29304 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) Q8I147 (/ISS)
Regulation of R7 cell differentiation GO:0045676
Any process that modulates the frequency, rate or extent of R7 differentiation.
6 P29304 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) Q8I147 (/ISS)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
4 P21461 (/IPI) P21461 (/IPI) P21461 (/IPI) P21461 (/IPI)
Sensory organ development GO:0007423
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
4 P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) P21461 (/IMP)
R7 cell fate commitment GO:0007465
The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium.
4 P21461 (/IGI) P21461 (/IGI) P21461 (/IGI) P21461 (/IGI)
R7 cell fate commitment GO:0007465
The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium.
4 P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) P21461 (/IMP)
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
4 P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) P21461 (/IDA)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
4 P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) P21461 (/IMP)
Enteroendocrine cell differentiation GO:0035883
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.
4 P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) P21461 (/IMP)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
4 P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) P21461 (/IDA)
Sevenless signaling pathway GO:0045500
A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P21461 (/IGI) P21461 (/IGI) P21461 (/IGI) P21461 (/IGI)
Regulation of R7 cell differentiation GO:0045676
Any process that modulates the frequency, rate or extent of R7 differentiation.
4 P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) P21461 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P29304 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) Q8I147 (/ISS)
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
4 P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) P21461 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) P21461 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) P21461 (/IDA)