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CATH Superfamily 3.30.40.10

Zinc/RING finger domain, C3HC4 (zinc finger)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Zinc/RING finger domain, C3HC4 (zinc finger)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: E3 ubiquitin-protein ligase RBX1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 128 F4K5K0 (/IPI) O13959 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI)
(118 more)
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
 67 O13959 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(57 more)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
 66 P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS)
(56 more)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
 62 P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS)
(52 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
 62 P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI)
(52 more)
Eukaryotic initiation factor 4E binding GO:0008190
Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.
 62 P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS)
(52 more)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Ubiquitin-ubiquitin ligase activity GO:0034450
Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Ubiquitin-ubiquitin ligase activity GO:0034450
Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
 62 P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO)
(52 more)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
 62 Q498D8 (/IPI) Q498D8 (/IPI) Q498D8 (/IPI) Q498D8 (/IPI) Q498D8 (/IPI) Q498D8 (/IPI) Q498D8 (/IPI) Q498D8 (/IPI) Q498D8 (/IPI) Q498D8 (/IPI)
(52 more)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
 62 P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO)
(52 more)
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
 62 P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO)
(52 more)
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Cullin family protein binding GO:0097602
Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3).
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Cullin family protein binding GO:0097602
Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3).
 62 P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO)
(52 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
 5 O13959 (/ISM) Q9W5E1 (/ISM) Q9W5E1 (/ISM) Q9W5E1 (/ISM) Q9W5E1 (/ISM)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
 4 Q9W5E1 (/NAS) Q9W5E1 (/NAS) Q9W5E1 (/NAS) Q9W5E1 (/NAS)
Cullin family protein binding GO:0097602
Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3).
 4 Q9W5E1 (/IPI) Q9W5E1 (/IPI) Q9W5E1 (/IPI) Q9W5E1 (/IPI)

There are 52 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
 128 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(118 more)
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
 128 P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS)
(118 more)
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
 125 O13959 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(115 more)
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
 66 P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS)
(56 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
 66 P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS)
(56 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
 66 P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS)
(56 more)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
 66 P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS)
(56 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
 63 F4K5K0 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(53 more)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Nucleotide-excision repair, DNA damage recognition GO:0000715
The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Nucleotide-excision repair, DNA duplex unwinding GO:0000717
The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Transcription-coupled nucleotide-excision repair GO:0006283
The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Nucleotide-excision repair, preincision complex stabilization GO:0006293
The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Nucleotide-excision repair, preincision complex assembly GO:0006294
The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Nucleotide-excision repair, DNA incision, 3'-to lesion GO:0006295
The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296
The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
 62 P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS)
(52 more)
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
 62 P62878 (/IGI) P62878 (/IGI) P62878 (/IGI) P62878 (/IGI) P62878 (/IGI) P62878 (/IGI) P62878 (/IGI) P62878 (/IGI) P62878 (/IGI) P62878 (/IGI)
(52 more)
SCF complex assembly GO:0010265
The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Negative regulation of G2/M transition of mitotic cell cycle GO:0010972
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
 62 P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI)
(52 more)
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
 62 P62878 (/IMP) P62878 (/IMP) P62878 (/IMP) P62878 (/IMP) P62878 (/IMP) P62878 (/IMP) P62878 (/IMP) P62878 (/IMP) P62878 (/IMP) P62878 (/IMP)
(52 more)
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
 62 P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI) P62877 (/IPI)
(52 more)
Nucleotide-excision repair, DNA incision GO:0033683
A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
DNA damage response, detection of DNA damage GO:0042769
The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Global genome nucleotide-excision repair GO:0070911
The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
 62 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(52 more)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
 4 Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
 4 Q9W5E1 (/NAS) Q9W5E1 (/NAS) Q9W5E1 (/NAS) Q9W5E1 (/NAS)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
 4 Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP)
Lipid storage GO:0019915
The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
 4 Q9W5E1 (/IDA) Q9W5E1 (/IDA) Q9W5E1 (/IDA) Q9W5E1 (/IDA)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
 4 Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP)
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
 4 Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
 4 Q9W5E1 (/IPI) Q9W5E1 (/IPI) Q9W5E1 (/IPI) Q9W5E1 (/IPI)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
 4 Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP)
Positive regulation of neuron remodeling GO:1904801
Any process that activates or increases the frequency, rate or extent of neuron remodeling.
 4 Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP)
Anterior/posterior axis specification, embryo GO:0008595
The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.
 1 Q23457 (/IMP)
Response to auxin GO:0009733
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
 1 F4K5K0 (/IMP)
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518
Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
 1 Q23457 (/IMP)
Sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation GO:0051759
The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II.
 1 Q23457 (/IMP)
Protein modification by small protein conjugation or removal GO:0070647
A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
 1 O13959 (/IC)
Positive regulation of metaphase/anaphase transition of meiotic cell cycle GO:1902104
Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle.
 1 Q23457 (/IMP)
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.
 1 Q23457 (/IMP)

There are 34 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
 128 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(118 more)
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
 128 P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS)
(118 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
 124 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(114 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 66 P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS) P62877 (/TAS)
(56 more)
Cul2-RING ubiquitin ligase complex GO:0031462
A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
 66 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(56 more)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
 66 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(56 more)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
 66 P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS)
(56 more)
Cul4A-RING E3 ubiquitin ligase complex GO:0031464
A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
 66 P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS)
(56 more)
Cul4B-RING E3 ubiquitin ligase complex GO:0031465
A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.
 66 P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS)
(56 more)
Cul7-RING ubiquitin ligase complex GO:0031467
A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.
 66 P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS) P62878 (/ISS)
(56 more)
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
 62 P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS)
(52 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Anaphase-promoting complex GO:0005680
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
 62 P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS) P62878 (/TAS)
(52 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 62 P62878 (/IDA) P62878 (/IDA) P62878 (/IDA) P62878 (/IDA) P62878 (/IDA) P62878 (/IDA) P62878 (/IDA) P62878 (/IDA) P62878 (/IDA) P62878 (/IDA)
(52 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 62 P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS) P62877 (/ISS)
(52 more)
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
 62 P62878 (/IPI) P62878 (/IPI) P62878 (/IPI) P62878 (/IPI) P62878 (/IPI) P62878 (/IPI) P62878 (/IPI) P62878 (/IPI) P62878 (/IPI) P62878 (/IPI)
(52 more)
VCB complex GO:0030891
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
 62 Q498D8 (/IDA) Q498D8 (/IDA) Q498D8 (/IDA) Q498D8 (/IDA) Q498D8 (/IDA) Q498D8 (/IDA) Q498D8 (/IDA) Q498D8 (/IDA) Q498D8 (/IDA) Q498D8 (/IDA)
(52 more)
VCB complex GO:0030891
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
 62 P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO)
(52 more)
Cullin-RING ubiquitin ligase complex GO:0031461
Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Cullin-RING ubiquitin ligase complex GO:0031461
Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
 62 P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO) P62878 (/ISO)
(52 more)
Cul4A-RING E3 ubiquitin ligase complex GO:0031464
A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Cul4B-RING E3 ubiquitin ligase complex GO:0031465
A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Cul5-RING ubiquitin ligase complex GO:0031466
A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Cul7-RING ubiquitin ligase complex GO:0031467
A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.
 62 P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA) P62877 (/IDA)
(52 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 5 O13959 (/IDA) Q9W5E1 (/IDA) Q9W5E1 (/IDA) Q9W5E1 (/IDA) Q9W5E1 (/IDA)
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
 4 Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP) Q9W5E1 (/IMP)
Cul4-RING E3 ubiquitin ligase complex GO:0080008
A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
 4 Q9W5E1 (/IDA) Q9W5E1 (/IDA) Q9W5E1 (/IDA) Q9W5E1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 1 O13959 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 1 O13959 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 1 O13959 (/HDA)
Cul2-RING ubiquitin ligase complex GO:0031462
A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
 1 Q23457 (/IPI)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
 1 F4K5K0 (/IPI)
Nuclear SCF ubiquitin ligase complex GO:0043224
A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
 1 O13959 (/IDA)
CLRC ubiquitin ligase complex GO:0043494
An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi.
 1 O13959 (/IDA)