×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 3.30.390.30

FAD/NAD-linked reductase, C-terminal dimerisation domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: FAD/NAD-linked reductase, C-terminal dimerisation domain

This superfamily represents the C-terminal domain in FAD- and NAD-linked reductases, which participates to dimerisation. This structural domain has a core alpha+beta sandwich structure consisting of beta(3,4)-alpha(3). The first two domains are of the same beta/beta/alpha fold. This domain can be found in several reductases such as: glutathione, trypanothione, thioredoxin, putidaredoxin reductases PMID:3656429,PMID:2355009,PMID:18300227,PMID:15299452,PMID:8771196,PMID:11481439,PMID:15095867, apoptosis-inducing factor (AIF), which contains a beta-hairpin loop insertion involved in its apoptogenic functions PMID:11967568,PMID:12198487, dihydrolipoyl dehydrogenase (also known as dihydrolipoamide dehydrogenase) PMID:8805537, NADH peroxidases PMID:7766608,PMID:1942054, biphenyl 2,3-dioxygenase, ferredoxin reductase (also known as NADH-dependent ferredoxin reductase, BphA4) PMID:11090282, 2-oxopropyl-CoM reductase (also known as NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase) PMID:12390015, flavocytochrome c sulphide dehydrogenase (FCSD), the flavin-binding subunit INTERPRO:IPR015323, INTERPRO:IPR037092,PMID:7939681.

Pfam clan [PfamClan:CL0608], INTERPRO:IPR016156

GO Diversity

Unique GO annotations
244 Unique GO terms

EC Diversity

Unique EC annotations
21 Unique EC terms

Species Diversity

Unique species annotations
16775 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 533
Domain clusters (>95% seq id): 71
Domain clusters (>35% seq id): 27
Unique PDBs: 240
Alignments
Structural Clusters (5A): 3
Structural Clusters (9A): 2
FunFam Clusters: 52
Function
Unique EC: 21
Unique GO: 244
Taxonomy
Unique Species: 16775
CATH-Gene3D is a Global Biodata Core Resource Learn more...