The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
TATA-Binding Protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: TATA-box-binding protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 52 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
24 P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI)
(14 more)
RNA polymerase III general transcription initiation factor activity GO:0000995
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC.
21 O13270 (/ISS) O45211 (/ISS) P20227 (/ISS) P27633 (/ISS) P29037 (/ISS) P29037 (/ISS) P32085 (/ISS) P53360 (/ISS) P53360 (/ISS) P53361 (/ISS)
(11 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
15 O43133 (/IDA) P28148 (/IDA) P28148 (/IDA) P29037 (/IDA) P29037 (/IDA) Q1JPY4 (/IDA) Q1JPY4 (/IDA) Q28DH2 (/IDA) Q28GG8 (/IDA) Q28GG8 (/IDA)
(5 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
15 P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI)
(5 more)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
11 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
(1 more)
TFIIA-class transcription factor complex binding GO:0001092
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
11 P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI)
(1 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
11 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
(1 more)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
10 P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP)
RNA polymerase III general transcription initiation factor activity GO:0000995
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC.
10 P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC)
RNA polymerase III regulatory region DNA binding GO:0001016
Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
10 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
10 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
10 P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI)
RNA polymerase I general transcription initiation factor binding GO:0001179
Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I.
10 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
RNA polymerase I general transcription initiation factor binding GO:0001179
Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I.
10 P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI)
RNA polymerase I transcription regulator recruiting activity GO:0001186
The function of binding to an RNA polymerase I (RNAP I) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation.
10 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
RNA polymerase I transcription regulator recruiting activity GO:0001186
The function of binding to an RNA polymerase I (RNAP I) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation.
10 P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI)
DNA binding, bending GO:0008301
The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
10 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
RNA polymerase II general transcription initiation factor activity GO:0016251
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP).
10 P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC) P13393 (/IC)
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
10 P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI) P13393 (/IPI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 P32085 (/IDA) Q5UE94 (/IDA) Q5UE94 (/IDA) Q6SJ95 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
3 P20227 (/IDA) P29037 (/IDA) P29037 (/IDA)
RNA polymerase III general transcription initiation factor activity GO:0000995
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC.
3 P17871 (/ISO) P29037 (/ISO) P29037 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 P27633 (/ISS) Q6SJ94 (/ISS) Q7SXL3 (/ISS)
RNA polymerase II general transcription initiation factor activity GO:0016251
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP).
3 P17871 (/ISO) P29037 (/ISO) P29037 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P20226 (/ISA) Q6SJ96 (/ISA)
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
2 P29037 (/ISO) P29037 (/ISO)
RNA polymerase III type 3 promoter sequence-specific DNA binding GO:0001006
Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.
2 P17871 (/IDA) P20227 (/IDA)
Core promoter binding GO:0001047
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 P20226 (/IDA) P20227 (/IDA)
Core promoter binding GO:0001047
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 P29037 (/ISO) P29037 (/ISO)
TFIIB-class transcription factor binding GO:0001093
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
2 P29037 (/ISO) P29037 (/ISO)
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
2 P29037 (/IPI) P29037 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P29037 (/ISO) P29037 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
2 P29037 (/ISO) P29037 (/ISO)
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
2 P28148 (/ISS) P28148 (/ISS)
Aryl hydrocarbon receptor binding GO:0017162
Interacting selectively and non-covalently with an aryl hydrocarbon receptor.
2 P29037 (/ISO) P29037 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 P29037 (/ISO) P29037 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q8ST28 (/IPI) Q8ST28 (/IPI)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 P20226 (/IDA) P20227 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 P29037 (/ISO) P29037 (/ISO)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
2 P29037 (/ISO) P29037 (/ISO)
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
1 P20226 (/IDA)
RNA polymerase III general transcription initiation factor activity GO:0000995
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC.
1 P20226 (/IMP)
TFIIB-class transcription factor binding GO:0001093
Interacting selectively and non-covalently with a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.
1 P20226 (/IPI)
RNA polymerase I general transcription initiation factor activity GO:0001181
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3.
1 P17871 (/ISO)
AT DNA binding GO:0003680
Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).
1 P32085 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 O43133 (/IGI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q28DH2 (/ISS)
RNA polymerase II general transcription initiation factor activity GO:0016251
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP).
1 P17871 (/EXP)
RNA polymerase II general transcription initiation factor activity GO:0016251
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP).
1 P20226 (/IDA)
Aryl hydrocarbon receptor binding GO:0017162
Interacting selectively and non-covalently with an aryl hydrocarbon receptor.
1 P20226 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P20226 (/IPI)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
1 P20226 (/IPI)

There are 56 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
22 O13270 (/ISS) O45211 (/ISS) P26355 (/ISS) P27633 (/ISS) P29037 (/ISS) P29037 (/ISS) P32085 (/ISS) P53360 (/ISS) P53360 (/ISS) P53361 (/ISS)
(12 more)
Transcription by RNA polymerase III GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
21 O13270 (/ISS) O45211 (/ISS) P26355 (/ISS) P27633 (/ISS) P29037 (/ISS) P29037 (/ISS) P32085 (/ISS) P53360 (/ISS) P53360 (/ISS) P53361 (/ISS)
(11 more)
Nucleolar large rRNA transcription by RNA polymerase I GO:0042790
The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.
10 P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP)
RNA polymerase II preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
10 P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP)
Transposon integration GO:0070893
Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome.
10 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
RNA polymerase III preinitiation complex assembly GO:0070898
The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter.
10 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
8 P20226 (/IMP) P20227 (/IMP) P27633 (/IMP) P29037 (/IMP) P29037 (/IMP) Q5UE94 (/IMP) Q5UE94 (/IMP) Q7SXL3 (/IMP)
DNA-templated transcription, initiation GO:0006352
Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
5 P20227 (/IDA) P28148 (/IDA) P28148 (/IDA) Q1JPY4 (/IDA) Q1JPY4 (/IDA)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
5 P27633 (/IMP) Q1JPY4 (/IMP) Q1JPY4 (/IMP) Q5UE94 (/IMP) Q5UE94 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
4 Q28DH2 (/ISS) Q28GG8 (/ISS) Q28GG8 (/ISS) Q6SJ94 (/ISS)
Transcription by RNA polymerase III GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
3 P20226 (/IMP) P29037 (/IMP) P29037 (/IMP)
Gastrulation GO:0007369
A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
3 Q5UE94 (/IMP) Q5UE94 (/IMP) Q7SXL3 (/IMP)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
2 Q5UE94 (/IDA) Q5UE94 (/IDA)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
2 P29037 (/ISO) P29037 (/ISO)
Transcription by RNA polymerase III GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
2 P20226 (/IDA) P20227 (/IDA)
Transcription by RNA polymerase III GO:0006383
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
2 P29037 (/ISO) P29037 (/ISO)
Embryonic pattern specification GO:0009880
The process that results in the patterns of cell differentiation that will arise in an embryo.
2 Q1JPY4 (/IMP) Q1JPY4 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
2 Q1JPY4 (/IMP) Q1JPY4 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P32085 (/IDA) Q66HB1 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P29037 (/ISO) P29037 (/ISO)
RNA polymerase II preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
2 P20226 (/IDA) P20227 (/IDA)
RNA polymerase II preinitiation complex assembly GO:0051123
The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
2 P29037 (/ISO) P29037 (/ISO)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 Q28DH2 (/ISS)
DNA-templated transcription, initiation GO:0006352
Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
1 Q7SXL3 (/ISS)
Regulation of transcription by RNA polymerase III GO:0006359
Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III.
1 P20227 (/IMP)
Transcription initiation from RNA polymerase I promoter GO:0006361
Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 P17871 (/IDA)
Transcription initiation from RNA polymerase I promoter GO:0006361
Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 P20226 (/TAS)
Transcription elongation from RNA polymerase I promoter GO:0006362
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.
1 P20226 (/TAS)
Termination of RNA polymerase I transcription GO:0006363
The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit.
1 P20226 (/TAS)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 P20226 (/IC)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 P20226 (/IDA)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 P27633 (/NAS)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 P20226 (/TAS)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 P20226 (/IC)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 P20227 (/IDA)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 O43133 (/IGI)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 P17871 (/ISO)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 P27633 (/NAS)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 P20226 (/TAS)
Transcription initiation from RNA polymerase III promoter GO:0006384
Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 P17871 (/ISO)
Transcription initiation from RNA polymerase III promoter GO:0006384
Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 P26355 (/ISS)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
1 Q7SXL3 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q66HB1 (/IEP)
Gastrulation GO:0007369
A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
1 Q28DH2 (/ISS)
Embryonic pattern specification GO:0009880
The process that results in the patterns of cell differentiation that will arise in an embryo.
1 Q6SJ94 (/ISS)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q6SJ94 (/ISS)
SnRNA transcription by RNA polymerase II GO:0042795
The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.
1 P20227 (/IDA)
SnRNA transcription by RNA polymerase II GO:0042795
The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.
1 P20226 (/TAS)
SnRNA transcription by RNA polymerase III GO:0042796
The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter.
1 P20227 (/IDA)
TRNA transcription by RNA polymerase III GO:0042797
The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter.
1 P20227 (/IDA)
TRNA transcription by RNA polymerase III GO:0042797
The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter.
1 P20227 (/IMP)
Positive regulation of gene expression, epigenetic GO:0045815
Any epigenetic process that activates or increases the rate of gene expression.
1 P20226 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q6SJ95 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P20227 (/IMP)
Positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261
Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
1 P20227 (/IDA)
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
1 P20226 (/TAS)

There are 37 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
21 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
(11 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
21 O13270 (/ISS) O45211 (/ISS) P27633 (/ISS) P53360 (/ISS) P53360 (/ISS) P53361 (/ISS) P53361 (/ISS) Q1JPY4 (/ISS) Q1JPY4 (/ISS) Q28DH2 (/ISS)
(11 more)
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
21 O13270 (/ISS) O45211 (/ISS) P20227 (/ISS) P27633 (/ISS) P29037 (/ISS) P29037 (/ISS) P32085 (/ISS) P53360 (/ISS) P53360 (/ISS) P53361 (/ISS)
(11 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
13 P13393 (/TAS) P13393 (/TAS) P13393 (/TAS) P13393 (/TAS) P13393 (/TAS) P13393 (/TAS) P13393 (/TAS) P13393 (/TAS) P13393 (/TAS) P13393 (/TAS)
(3 more)
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
13 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
(3 more)
Transcription factor TFIIIB complex GO:0000126
A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.
12 P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA) P13393 (/IDA)
(2 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
11 P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP)
(1 more)
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
10 P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP) P13393 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P29037 (/IDA) P29037 (/IDA) Q6SJ95 (/IDA) Q6SJ96 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P26355 (/IC) Q1JPY4 (/IC) Q1JPY4 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P29037 (/ISO) P29037 (/ISO) Q6SJ95 (/ISO)
RNA polymerase I transcription factor complex GO:0000120
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I.
2 P29037 (/TAS) P29037 (/TAS)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
2 P29037 (/ISO) P29037 (/ISO)
Female pronucleus GO:0001939
The pronucleus originating from the ovum that is being fertilized.
2 P29037 (/IDA) P29037 (/IDA)
Male pronucleus GO:0001940
The pronucleus originating from the spermatozoa that was involved in fertilization.
2 P29037 (/IDA) P29037 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P29037 (/ISO) P29037 (/ISO)
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
2 P29037 (/ISO) P29037 (/ISO)
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
2 P29037 (/ISO) P29037 (/ISO)
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
2 P29037 (/ISO) P29037 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P29037 (/ISO) P29037 (/ISO)
Pronucleus GO:0045120
The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.
2 P29037 (/IDA) P29037 (/IDA)
Transcriptional preinitiation complex GO:0097550
A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.
2 P29037 (/ISO) P29037 (/ISO)
RNA polymerase I transcription factor complex GO:0000120
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I.
1 P17871 (/IDA)
Transcription factor TFIIIB complex GO:0000126
A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.
1 P20227 (/IPI)
Transcription factor TFIIIB complex GO:0000126
A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.
1 P17871 (/ISO)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 P20226 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P17871 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P20226 (/IDA)
RNA polymerase III complex GO:0005666
RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
1 P20227 (/IC)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 O43133 (/IGI)
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
1 P20227 (/IPI)
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
1 P27633 (/NAS)
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
1 P20226 (/TAS)
Transcription factor TFIIA complex GO:0005672
A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
1 P20226 (/IDA)
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
1 P20226 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q6SJ95 (/ISO)
Transcriptional preinitiation complex GO:0097550
A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.
1 P20226 (/IDA)