The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 277: serine/threonine-protein kinase greatwall isoform ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
8 B1WAR9 (/ISS) D2HXI8 (/ISS) E1BFR5 (/ISS) E1C2I2 (/ISS) E2RJI4 (/ISS) F1RVK2 (/ISS) Q6DBX4 (/ISS) Q8C0P0 (/ISS)
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
8 B1WAR9 (/ISS) D2HXI8 (/ISS) E1BFR5 (/ISS) E1C2I2 (/ISS) E2RJI4 (/ISS) Q6DBX4 (/ISS) Q8C0P0 (/ISS) Q96GX5 (/ISS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q6NTJ3 (/IDA) Q96GX5 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q8C0P0 (/ISO)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q96GX5 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q6NTJ3 (/IPI)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 Q96GX5 (/IDA)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 Q8C0P0 (/ISO)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 F1RVK2 (/ISS)
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
1 Q6NTJ3 (/IDA)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
8 B1WAR9 (/ISS) D2HXI8 (/ISS) E1BFR5 (/ISS) E1C2I2 (/ISS) E2RJI4 (/ISS) F1RVK2 (/ISS) Q6DBX4 (/ISS) Q8C0P0 (/ISS)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
8 B1WAR9 (/ISS) D2HXI8 (/ISS) E1BFR5 (/ISS) E1C2I2 (/ISS) E2RJI4 (/ISS) F1RVK2 (/ISS) Q6DBX4 (/ISS) Q8C0P0 (/ISS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
8 B1WAR9 (/ISS) D2HXI8 (/ISS) E1BFR5 (/ISS) E1C2I2 (/ISS) E2RJI4 (/ISS) Q6DBX4 (/ISS) Q8C0P0 (/ISS) Q96GX5 (/ISS)
Negative regulation of phosphoprotein phosphatase activity GO:0032515
Any process that stops or reduces the activity of a phosphoprotein phosphatase.
8 B1WAR9 (/ISS) D2HXI8 (/ISS) E1BFR5 (/ISS) E1C2I2 (/ISS) E2RJI4 (/ISS) F1RVK2 (/ISS) Q6DBX4 (/ISS) Q8C0P0 (/ISS)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
2 Q6NTJ3 (/IMP) Q96GX5 (/IMP)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
2 Q6NTJ3 (/IMP) Q96GX5 (/IMP)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
1 Q8C0P0 (/ISO)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 Q8C0P0 (/ISO)
Thrombocyte differentiation GO:0002574
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
1 Q6DBX4 (/IMP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 Q6NTJ3 (/IDA)
Female meiosis II GO:0007147
The cell cycle process in which the second meiotic division occurs in the female germline.
1 Q8C0P0 (/IMP)
Female meiosis II GO:0007147
The cell cycle process in which the second meiotic division occurs in the female germline.
1 F1RVK2 (/ISS)
Meiotic chromosome condensation GO:0010032
Compaction of chromatin structure prior to meiosis in eukaryotic cells.
1 F1RVK2 (/IMP)
Negative regulation of phosphoprotein phosphatase activity GO:0032515
Any process that stops or reduces the activity of a phosphoprotein phosphatase.
1 Q6NTJ3 (/IDA)
Negative regulation of phosphoprotein phosphatase activity GO:0032515
Any process that stops or reduces the activity of a phosphoprotein phosphatase.
1 Q96GX5 (/IMP)
Negative regulation of phosphoprotein phosphatase activity GO:0032515
Any process that stops or reduces the activity of a phosphoprotein phosphatase.
1 Q8C0P0 (/ISO)
Negative regulation of phosphoprotein phosphatase activity GO:0032515
Any process that stops or reduces the activity of a phosphoprotein phosphatase.
1 Q6NTJ3 (/TAS)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 Q6NTJ3 (/TAS)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q96GX5 (/IMP)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q8C0P0 (/ISO)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 F1RVK2 (/ISS)
Regulation of cell cycle arrest GO:0071156
Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
1 F1RVK2 (/IMP)
Spindle assembly involved in meiosis GO:0090306
The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis.
1 F1RVK2 (/IMP)
Positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146
Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
1 F1RVK2 (/IMP)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division GO:1904191
Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division.
1 F1RVK2 (/IMP)
Positive regulation of ubiquitin protein ligase activity GO:1904668
Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity.
1 Q8C0P0 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
9 B1WAR9 (/ISS) D2HXI8 (/ISS) E1BFR5 (/ISS) E1C2I2 (/ISS) E2RJI4 (/ISS) F1RVK2 (/ISS) Q6DBX4 (/ISS) Q6NTJ3 (/ISS) Q8C0P0 (/ISS)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
9 B1WAR9 (/ISS) D2HXI8 (/ISS) E1BFR5 (/ISS) E1C2I2 (/ISS) E2RJI4 (/ISS) F1RVK2 (/ISS) Q6DBX4 (/ISS) Q6NTJ3 (/ISS) Q8C0P0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 B1WAR9 (/ISS) D2HXI8 (/ISS) E1BFR5 (/ISS) E1C2I2 (/ISS) E2RJI4 (/ISS) Q6DBX4 (/ISS) Q6NTJ3 (/ISS) Q8C0P0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 F1RVK2 (/IDA) Q96GX5 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q6NTJ3 (/TAS) Q96GX5 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8C0P0 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q96GX5 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8C0P0 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 F1RVK2 (/ISS)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q96GX5 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q8C0P0 (/ISO)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
1 Q96GX5 (/IDA)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
1 Q8C0P0 (/ISO)
Meiotic spindle GO:0072687
A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.
1 F1RVK2 (/IDA)